Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Nachweis von Oxytyramin (Dopamin) in sympathischen Nerven und Ganglien

  • 35 Accesses

  • 34 Citations

Summary

  1. 1.

    The presence of hydroxy-tyramine in extracts from sympathetic nerves (splenic nerves) and sympathetic ganglia (stellata ganglia) is shown by paper-chromatography and pharmacological assay.

  2. 2.

    The hydroxy-tyramine content of the extracts is nearly 50% of the total amount of catechol-amines.

  3. 3.

    This result indicates that hydroxy-tyramine — formed by the 1(—) dopadecarboxylase of the nervous tissue — is the precursor of the nor-adrenaline in sympathetic nerves and ganglia, and furthermore that the biosynthesis of nor-adrenaline from hydroxy-tyramine will take place in the nervous tissue itself.

This is a preview of subscription content, log in to check access.

Literatur

  1. Crawford, T. B., and A. S. Outschoorn: Brit. J. Pharmacol. 6, 8 (1951).

  2. v. Euler, U. S.: Arch. internat. Pharmacodynamic 77, 477 (1948); Acta physiol. scand. (Stockh.) 19, 207 (1949).

  3. Goodall, Mc: Acta physiol. scand. (Stockh.) 24, Suppl. 85 (1951).

  4. Hamberg, U., and U. S. v. Euler: Acta chem. scand. (Copenh.) 4, 1185 (1950).

  5. Holtz, P., u. E. Westermann: Naturwissenschaften 1955, 647; Arch. exper. Path. u. Pharmakol. 227, 538 (1956).

  6. Holtz, P., u. K. Credner: Arch. exper. Path. u. Pharmakol. 200, 356 (1942).

  7. James, W. O.: Nature (Lond.) 161, 851 (1948).

  8. Shepherd, D. M., and G. B. West: J. of Physiol. 120, 15 (1953).

  9. Vogt, M.: Brit. J. Pharmacol. 7, 325 (1952).

Download references

Author information

Additional information

Mit 7 Textabbildungen

Kurze Mitteilung siehe H. J. Schümann: Naturwiss. 1956, 37.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Schümann, H.J. Nachweis von Oxytyramin (Dopamin) in sympathischen Nerven und Ganglien. Naunyn - Schmiedebergs Arch 227, 566–573 (1956). https://doi.org/10.1007/BF00246527

Download citation