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The phosphaturic response of thyroparathyroidectomized dogs to the administration of parathyroid hormone by unilateral renal arterial infusion

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Acutely thyroparathyroidectomized dogs were administered partially purified parathyroid hormone by way of the left renal artery. When the hormone was given by this route at a relatively high dose, either by injection of 30 or more units or as a continuous infusion at the rate of 30 units/hour, the renal response, an increase in the % of filtered phosphate excreted, was rapid and essentially identical by both kidneys. On the other hand, when the parathyroid hormone preparation was infused into the renal artery at a relatively slow rate (1–12.5 units/hour), the response either was confined to the infused kidney or it was greater by the infused kidney than by the noninfused kidney. Control infusions of physiological salt solution or of a nonparathyroid tissue extract resulted in no differential effect on the infused kidney. These results, added to those of similar experiments in intact dogs by Pullman, Lavender, Aho, and Rasmussen, support the conclusion that parathyroid hormone acts directly on the mammalian renal tubule.

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Dedicated to Professor Otto Krayer on his 65th birthday.

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This investigation was supported in part by a research grant (A-1787) from the National Institute for Arthritis and Metabolic Diseases, U.S. Public Health Service.

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Hirsch, P.F., Munson, P.L. The phosphaturic response of thyroparathyroidectomized dogs to the administration of parathyroid hormone by unilateral renal arterial infusion. Naunyn - Schmiedebergs Arch 248, 319–330 (1964).

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  • Phosphate
  • Renal Artery
  • Salt Solution
  • Differential Effect
  • Slow Rate