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Responses of guinea pig primary vestibular neurons to clicks

Abstract

Responses of single neurons in the vestibular nerve to high-intensity clicks were studied by extracellular recording in anaesthetised guinea pigs. One hundred and two neurons in the posterior division of the superior branch or in the inferior branch of the vestibular nerve were activated at short latency by intense clicks. The latency of activation was short (median 0.9 ms) and the threshold was high: the click intensity for evoking the response of these cells was around 60 dB above the auditory brainstem response threshold. Animals were tilted and rotated to identify physiologically the sensory region of the labyrinth from which the activated neurons originated. Seventeen neurons responded to static tilt as well as clicks. These results show that vestibular receptors, probably the otoliths, respond to clicks at intensities corresponding to those used in a new clinical test of the vestibulo-collic pathway.

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References

  1. Cazals Y, Aran J-M, Erre J-P, Guilhaume A (1980) Acoustic responses after total destruction of the cochlear receptor: brainstem and auditory cortex. Science 210:83–86

  2. Cazals Y, Aran J-M, Erre J-P (1982) Frequency sensitivity and selectivity of acoustically evoked potentials after complete cochlear hair cell destruction. Brain Res 231:197–203

  3. Cody DTR, Jacobson JL, Walker JC, Bickford RG (1964) Averaged evoked myogenic and cortical potentials to sound in man. Ann Otol Rhinol Laryngol 73:763–777

  4. Colebatch JG, Halmagyi GM, Skuse NF (1994) Myogenic potentials generated by a click-evoked vestibulocollic reflex. J Neurol Neurosurg Psychiatr 57:190–197

  5. Colebatch JG, Rothwell JC, Bronstein A, Ludman H (In press) Click-evoked vestibular activation in the Tullio phenomenon. J Neurol Neurosurg Psychiatr

  6. Curthoys IS (1981) Scarpa's ganglion in the rat and guinea pig. Acta Otolaryngol (Stockh) 92:107–113

  7. Curthoys IS (1982) The response of primary horizontal semicircular canal neurons in the rat and guinea pig to angular acceleration. Exp Brain Res 47:286–294

  8. Dallos P, Harris D, Özdamar Ö, Ryan A (1978) Behavioral, compound action potential, and single unit thresholds: relationship in normal and abnormal ears. J Acoust Soc Am 64:151–157

  9. Didier A, Cazais Y (1989) Acoustic responses recorded from the saccular bundle on the eighth nerve of the guinea pig. Hearing Res 37:123–128

  10. Dieterich M, Brandt T, Fries W (1989) Otolith function in man. Results from a case of otolith Tullio phenomenon. Brain 112:1377–1392

  11. Fernández C, Goldberg JM (1976) Physiology of peripheral neurons innervating otolith organs of the squirrel monkey. I. Response to static tilts and to long-duration centrifugal force. J Neurophysiol 39:970–984

  12. Fullerton BC, Levine RA, Hosford-Dunn HL, Kiang NYS (1987) Comparison of cat and human brain-stem auditory evoked potentials. Electroencephalogr Clin Neurophysiol 66:547–570

  13. Gacek RR (1969) The course and central termination of first order neurons supplying vestibular endorgans in the cat. Acta Otolaryngol (Stockh) [Suppl] 254:1–66

  14. Goldberg JM, Fernández C (1977) Conduction times and background discharge of vestibular afferents. Brain Res 122:545–550

  15. Goldberg JM, Minor LB, Fernández C (1988) The functional organization of the vestibular labyrinth and of some of its central pathways. In: Hwang JC, Daunton NG, Wilson VJ (ed) Basic and applied aspects of vestibular function. Hong Kong University Press, Hong Kong, pp 3–12

  16. Gstoettner W, Burian M (1987) Vestibular nuclear complex in the guinea pig: a cytoarchitectonic study and map in three planes. J Comp Neurol 257:176–188

  17. Kiang NYS, Watanabe T, Thomas EC, Clark LF (1965) Discharge patterns of single fibres in the cat's auditory nerve. MIT Press, Cambridge

  18. Murofushi T, Kaga K, Asakage T (1994) Temporary latency shifts in auditory evoked potentials by injection of lidocaine in the rat. Hearing Res 76:53–59

  19. Pralong D, Carlile S (1994) Measuring the human head-related transfer functions: a novel method for the construction and calibration of a miniature “in-ear” recording system. J Acoust Soc Am 95:3435–3444

  20. Wada S, Starr A (1983) Generation of auditory brain stem responses (ABRs). I. Effects of injection of a local anesthetic procaine HCl into the trapezoid body of guinea pigs and cat. Electroencephalogr Clin Neurophysiol 56:326–339

  21. Young ED, Fernández C, Goldberg JM (1977) Responses of squirrel monkey vestibular neurons to audio-frequency sound and head vibration. Acta Otolaryngol (Stockh) 84:352–360

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Murofushi, T., Curthoys, I.S., Topple, A.N. et al. Responses of guinea pig primary vestibular neurons to clicks. Exp Brain Res 103, 174–178 (1995). https://doi.org/10.1007/BF00241975

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Key words

  • Tullio phenomenon
  • Otolith
  • Vestibular Saccule
  • Utricle
  • Guinea pig