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Cerebellar afferent projections from the vestibular nuclei in the cat: An experimental study with the method of retrograde axonal transport of horseradish peroxidase

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Summary

Details of cerebellar afferent projections from the vestibular nuclei were investigated by the method of retrograde axonal transport of horseradish peroxidase (HRP) in the cat. The distribution of labeled cells in the vestibular nuclei following HRP injections in various parts of the cerebellum indicates that vestibular neurons in the medial and descending nuclei and cell groups f and x project bilaterally to the entire cerebellar vermis, the flocculus, the fastigial nucleus and the anterior and posterior interpositus nuclei. In addition, labeled cells (giant, medium and small) were consistently found bilaterally in the superior and lateral vestibular nuclei following HRP injections in the nodulus, flocculus, fastigial nucleus, and following large injections in the vermis. No labeled cells were observed in cases of HRP injections in crus I and II, the paramedian lobule, paraflocculus and lateral cerebellar nuclei. The present findings indicate that secondary vestibulocerebellar fibers project to larger areas in the cerebellum and originate from more subdivisions and cell groups of the vestibular nuclear complex than previously known.

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Abbreviations

B.c.:

superior cerebellar peduncle (brachium conjunctivum)

D:

descending (inferior) vestibular nucleus

f:

cell group f in descending vestibular nucleus

g:

group rich in glia cells, caudal to the medial vestibular nucleus

HIX:

hemispheral lobule IX

HVIIA cr. Ia, p; cr. IIa, p:

anterior and posterior folia of crus I and II of the ansiform lobule

HVIIB, HVIIIA, B:

sublobules A and B of hemispheral lobules VII and VIII

i.c.:

nucleus intercalatus (Staderini)

L:

lateral vestibular nucleus (Deiters)

l:

small-celled lateral group of lateral vestibular nucleus

M:

medial (triangular or dorsal) vestibular nucleus

N. cu. e.:

accessory cuneate nucleus

N. f. c.:

cuneate nucleus

N. mes. V:

mesencephalic nucleus of trigeminal nerve

N.tr. s.:

nucleus of solitary tract

N. VII:

facial nerve

pfl. d.:

dorsal paraflocculus

pfl. v.:

ventral paraflocculus

S:

superior vestibular nucleus (Bechterew)

Sv.:

cell group probably representing the nucleus supravestibularis

Tr. s.:

solitary tract

x:

small-celled group x, lateral to the descending vestibular nucleus

y:

small-celled groupy, lateral to the lateral vestibular nucleus (Deiters)

z:

cell group dorsal to the caudal part of the descending vestibular nucleus

I–VI:

vermian lobules I–VI

V, VI, XII:

cranial motor nerve nuclei

VIIA, B; VIIIA, B:

anterior and posterior sublobules of lobules VII and VIII

IX:

uvula

X:

nodulus; dorsal motor nucleus of vagus nerve

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On leave from the Laboratory of Neurobiology and Department of Anatomy, Faculty of Science, Mahidol University, Bangkok, Thailand, under the Felllowship Program of the Norwegian Agency for International Development (NORAD)

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Kotchabhakdi, N., Walberg, F. Cerebellar afferent projections from the vestibular nuclei in the cat: An experimental study with the method of retrograde axonal transport of horseradish peroxidase. Exp Brain Res 31, 591–604 (1978). https://doi.org/10.1007/BF00239814

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Key words

  • Cerebellar afferent projection
  • Vestibular nuclei
  • Horseradish peroxidase
  • Secondary vestibulocerebellar afferents