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Premotor cortex of the rhesus monkey: neuronal activity in anticipation of predictable environmental events

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The activity of premotor cortex neurons was studied in macaque monkeys that were operantly conditioned to perform a visually guided motor task. The monkeys were given a visuospatial instruction stimulus (IS) that provided the target for a limb movement, but the monkey was not allowed to execute the movement until the later presentation of a trigger stimulus (TS). The IS was sometimes removed or the target changed during the interval between the IS and TS. Certain neurons became active before the IS, appearing to anticipate its location or time of occurrence, some of these and other neurons increased or decreased their discharge prior to a possible change in the IS, and other cells showed neuronal modulation that preceded the TS. The properties of some of these neurons were examined when the timing of the behavior-guiding visual signals or their probability of occurrence was made less predictable. In general, the neuronal activity described here was strongly influenced by changes in event predictability. These findings suggest that neuronal activity within the premotor cortex reflects the anticipation of predictable environmental events.

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  1. Arthur DL, Starr A (1984) Task-relevant late positive component of the event-related potential in monkeys resembles P300 in humans. Science 223: 186–188

  2. Bakay-Pragay E, Mirsky AF, Ray CL, Turner DF, Mirsky CV (1978) Neuronal activity in the brain stem reticular formation during performance of a ‘go-no go’ visual attention task in the monkey. Exp Neurol 60: 83–95

  3. Bakay-Pragay E, Mirsky AF, Mirsky C, Scales BH (1980) Characteristics of attention-related cells in prefrontal cortical regions. Soc Neurosci Abstr 6: 813

  4. Belen'kii VY, Gurfinkel VS, Pal'tsev YI (1967) On the elements of voluntary movement. Biophysics 12: 154–160

  5. Bruce CJ, Goldberg ME (1985) Primate frontal eye fields: Single neurons discharging before saccades. J Neurophysiol 53: 603–635

  6. Brunia CHM, Haagh SAVM, Scheirs, JGM (1985) Waiting to respond: electrophysiological measurements in man during preparation for a voluntary movement. In: Heuer H, Kleinbeck U, Schmidt KH (eds) Motor behavior, programming control and acquisition. Springer, Berlin Heidelberg New York Tokyo

  7. Cordo PJ, Nashner LM (1982) Properties of postural adjustments associated with rapid arm movements. J Neurophysiol 47: 287–302

  8. Creutzfeldt OD, Watanabe S, Lux HD (1966) Relations between EEG phenomena and potentials of single cortical cells. Electrenceph Clin Neurophysiol 20: 1–18

  9. Donchin E, Gelbrandt LK, Leifer L, Tucker L (1972) Is the contingent negative variation contingent on a motor response? Psychophysiology 9: 178–188

  10. Evarts EV, Shinoda Y, Wise SP (1984) Neurophysiological Approaches to Higher Brain Function. Wiley-Interscience Press, New York

  11. Fischer B, Boch R, Ramsperger E (1984) Express-saccades of the monkey: effect of daily training on probability of occurrence and reaction time. Exp Brain Res 55: 232–242

  12. Freund H-J, Hummelsheim H (1984) The premotor syndrome in man: evidence for innervation of proximal limb muscles. Exp Brain Res 53: 479–482

  13. Godschalk M, Lemon RN (1983) Involvement of monkey premotor cortex in the preparation of arm movements. Exp Brain Res Suppl 7: 114–119

  14. Godschalk M, Lemon RN, Nijs HGT, Kuypers HGJM (1981) Behavior of neurons in monkey peri-arcuate and precentral cortex before and during visually guided arm and hand movements. Exp Brain Res 44: 113–116

  15. Godschalk M, Lemon RN, Kuypers HGJM, Ronday HK (1984) Cortical afferents and efferents of monkey postarcuate area: an anatomical and electrophysiological study. Exp Brain Res 56: 410–424

  16. Kutas M, Donchin E (1980) Preparation to respond as manifested by movement-related brain potentials. Brain Res 202: 95–115

  17. Lamour Y, Jennings V, Solis H (1980) Neuronal activity in monkey somatosensory (SI) and motor (MI) cortex related to anticipation of passive displacement and active contractions of the forelimb. Neurosci Lett Suppl 5: S480

  18. Lecas JC, Requin J, Vitton N (1983) Anticipatory activity in the monkey precentral cortex during reaction time foreperiod: preliminary results. Exp Brain Res Suppl 7: 120–129

  19. Loveless NE, Sanford AJ (1974) Effects of age on contingent negative variation and preparatory set in a reaction-time task. J Gerontol 29: 52–63

  20. McSherry JW, Borda RP, Hiblitz JJ (1977) Analysis of event-related slow potentials in primates. Prog Clin Neurophysiol 1: 231–241

  21. Muakassa KF, Strick P (1979) Frontal lobe inputs to primate premotor cortex: Evidence for four somatotopically organized ‘premotor’ areas. Brain Res 177: 176–182

  22. Niki H, Watanabe M (1979) Prefrontal and cingulate unit activity during timing behavior in the monkey. Brain Res 171: 213–224

  23. Ritter W, Simson R, Vaughn HG (1979) Association cortex potentials and reaction time in auditory discrimination. Science 203: 1358–1361

  24. Rizzolatti G, Matelli M, Pavesi G (1983) Deficits in attention and movement following the removal of postarcuate (area 6) and prearcuate (area 8) cortex in macaque monkeys. Brain Res 106: 655–673

  25. Schmidt EM, Jost RG, Davis KK (1974) Cortical cell discharge patterns in anticipation of a trained movement. Brain Res 75: 309–311

  26. Sternberg S (1969) The discovery of processing stages: Extensions of Donders' method. Acta Psychol 30: 276–315

  27. Sutton S, Braren M, Zubin J, John ER (1965) Evoked-potential correlates of stimulus uncertainty. Science 150: 1187–1188

  28. Tanji J, Evarts EV (1976) Anticipatory activity of motor cortex neurons in relation to direction of an intended movement. J Neurophysiol 39: 1062–1068

  29. Tanji J, Taniguchi K, Saga T (1980) Supplementary motor area: neural response to motor instructions. J Neurophysiol 43: 60–68

  30. Walter EG, Cooper R, Aldridge VJ, McCullum WC, Winter AL (1964) Contingent negative variation: an electric sign of sensorimotor association and expectancy in the human brain. Nature (Lond) 203: 380–384

  31. Weinrich M, Wise SP (1982) The premotor cortex of the monkey. J Neurosci 2: 1329–1345

  32. Weinrich M, Wise SP, Mauritz K-H (1984) A neurophysiological analysis of the premotor cortex of the monkey. Brain 107: 385–414

  33. Wiesendanger M (1981) Organization of secondary motor areas of cerebral cortex. Hand Physiol (Sect 1) 2 (1): 1121–1147

  34. Wise SP (1984) The nonprimary motor cortex and its role in the cerebral control of movement. In: G Edelmann, WE Gall, WM Cowan (eds) Dynamic aspects of neocortical function. Wiley-Interscience Press, New York, pp 525–555

  35. Wise SP (1985) The primate premotor cortex: past, present, and preparatory. Ann Rev Neurosci 8: 1–19

  36. Wise SP, Mauritz K-H (1985) Set-related neuronal activity in the premotor cortex of rhesus monkeys: effects of changes in motor set. Proc R Soc (Lond), Ser B, 223: 331–354

  37. Wise SP, Weinrich M, Mauritz K-H (1983) Motor aspects of cue-related neuronal activity in premotor cortex of the rhesus monkey. Brain Res 260: 301–305

  38. Wise SP, Weinrich M, Mauritz K-H (1986) Movement-related activity in the premotor cortex of rhesus macaques. Prog Brain Res (in press)

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Correspondence to S. P. Wise.

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Mauritz, K.-., Wise, S.P. Premotor cortex of the rhesus monkey: neuronal activity in anticipation of predictable environmental events. Exp Brain Res 61, 229–244 (1986).

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Key words

  • Neocortex
  • Monkey
  • Premotor cortex
  • Motor cortex
  • Postarcuate cortex
  • Single-unit activity