Fifty-eight lumbar dorsal horn and trigeminal nucleus caudalis neurones which could be activated by both innocuous and noxious peripheral stimuli have been recorded in the anaesthetized rat. Using transcutaneous electrical stimulation to produce A and C fibre activity in these neurones from the hindpaw or facial receptive fields the ability of a distant noxious (mechanical or thermal) stimulus applied to the nose, tail, ears and paws to inhibit the neuronal activity was demonstrated. These effects have been termed diffuse noxious inhibitory controls (DNIC). DNIC produced powerful long-lasting inhibitions on all units studied in accordance with our previous results.
Approximately 40% of these convergent neurones could be antidromically activated from the contralateral ventrobasal thalamus. Similar neuronal characteristics, effects of DNIC and proportions of projection cells were found in both the dorsal horn and trigeminal complex. However, the spinothalamic tract cells conducted more rapidly than the trigeminothalamic neurones.
These results indicate that DNIC can produce comparable effects on the thalamic representation of the efferent activity of these spinal cord and trigeminal neurones. The possible role of DNIC in nociception is discussed.
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Albe-Fessard D, Levante A, Lamour Y (1974) Origin of spinothalamic and spinoreticular pathways in cats and monkeys. In: Bonica JJ (ed) Advances in neurology, vol 4. Raven Press, New York, p 157
Berlin L, Goodell H, Wolff HG (1958) Relation of pain perception and central inhibitory effect of noxious stimulation to phenomenon of extinction of pain. AMA Arch Neurol Psychiatry 80: 533–543
Brown AG, Rethelyi M (1981) Spinal cord sensation. Scottish Academic Press, Edinburgh
Carstens E, Trevino DL (1976) Laminar origins of spinothalamic projections in the cat as determined by retrograde transport of horseradish peroxidase. J Comp Neurol 182: 151–166
Chung JM, Kenshalo DR Jr, Gerhart KD, Willis WD (1979) Excitation of primate spinothalamic tract neurons by cutaneous C fiber volleys. J Neurophysiol 42: 1354–1369
Dickenson AH, Le Bars D (1982) Diffuse noxious inhibitory controls (DNIC) can modulate rat trigemino- and spinothalamic convergent neurones. J Physiol (Lond) 325: 81P
Dickenson AH, Le Bars D, Besson JM (1980) Diffuse noxious inhibitory controls (DNIC). Effects on trigeminal nucleus caudalis neurones in the rat. Brain Res 200: 293–305
Duncker K (1937) Some preliminary experiments on the mutual influence of pains. Psychol Forsch 21: 311–326
Erzurumlu RS, Bates CA, Killackey HP (1980) Differential organization of thalamic projection cells in the brain stem trigeminal complex of the rat. Brain Res 198: 427–433
Fukushima T, Kerr FWL (1979) Organization of trigeminothalamic tracts and other thalamic afferent systems of the brainstem in the rat: Presence of gelatinosa neurons with thalamic connections. J Comp Neurol 183: 169–184
Gerhart KD, Yezierski RP, Giesler GJ Jr, Willis WD (1982) Inhibitory receptive fields of primate spinothalamic tract cells. J Neurophysiol 46: 1309–1375
Giesler GJ Jr, Menetry D, Basbaum AI (1979) Differential origins of spinothalamic tract projections to medial and lateral thalamus in the rat. J Comp Neurol 184: 107–126
Giesler GJ Jr, Menetry DM, Guilbaud G, Besson JM (1976) Lumbar cord neurons at the origin of the spinothalamic tract in the rat. Brain Res 118: 320–324
Giesler GJ Jr, Yezierski RP, Gerhart KD, Willis WD (1981) Spinothalamic tract neurons that project to medial and/or lateral thalamic nuclei evidence for a physiologically novel population of spinal cord neurons. J Neurophysiol 46: 1285–1308
Gobel S, Falls WM, Hockfield S (1977) The division of the dorsal and ventral horns of the mammalian caudal medulla into eight layers using anatomical criteria. In: Anderson DJ, Matthews BJ (eds) Pain in the trigeminal region. Elsevier/North Holland Amsterdam, pp 443–453
Hayes RL, Price DD, Dubner R (1979) Behavioural and physiological studies of sensory coding and modulation of trigeminal nociceptive input. In: Bonica JJ, Albe-Fessard D (eds) Advances in pain research, vol 3. Raven Press, New York, p 219
Kraus E, Le Bars D, Besson JM (1981) Behavioural confirmation of diffuse noxious inhibitory controls (DNIC) and evidence for a role of endogenous opiates. Brain Res 206: 495–499
Le Bars D, Dickenson AH, Besson JM (1979a) Diffuse noxious inhibitory controls (DNIC). I. Effect on dorsal horn convergent neurones. Pain 6: 283–304
Le Bars D, Dickenson AH, Besson JM (1979b) Diffuse noxious inhibitory controls (DNIC). II. Lack of effect on non-convergent neurones, supraspinal involvement and theoretical implications. Pain 6: 305–327
Le Bars D, Chitour D, Clot AM (1981a) The encoding of thermal stimuli by diffuse noxious inhibitory controls (DNIC). Brain Res 230: 394–399
Le Bars D, Chitour D, Kraus E, Clot AM, Dickenson AH, Besson JM (1981b) The effect of systemic morphine upon diffuse noxious inhibitory controls (DNIC) in the rat: Evidence for a lifting of certain descending inhibitory controls of dorsal horn convergent neurones. Brain Res 215: 257–274
Lund RD, Webster KE (1967) Thalamic afferents from the spinal cord and trigeminal nuclei — an experimental anatomical study in the rat. J Comp Neurol 130: 313–328
Mehler WR (1969) Some neurological species differences — a posteriori. Ann NY Acad Sci 167: 424–468
Milne RJ, Foreman RD, Giesler GJ, jr, Willis WD (1981) Convergence of cutaneous and pelvic visceral nociceptive inputs onto primate spinothalamic neurons. Pain 11: 163–183
Melzack R (1975) Prolonged relief of pain by brief, intense transcutaneous somatic stimulation. Pain 1: 357–373
Pellegrino LJ, Pellegrino AS, Cushman AJ (1979) A stereotaxic atlas of the rat brain. Plenum Press, New York
Price DD, Dubner R, Hu JW (1976) Trigeminothalamic neurons in nucleus caudalis responsive to tactile, thermal and nociceptive stimulation of the monkey's face. J Neurophysiol 39: 936–952
Price DD, Mayer DJ (1974) Physiological laminar organization of the dorsal horn of M. mulatto. Brain Res 79: 321–325
Ramón y Cajal S (1909) Histologie du système nerveux
Saporta S, Kruger L (1979) The organization of projections to selected points of somatosensory cortex from the cat ventrobasal complex. Brain Res 178: 279–295
Stewart WA, King RB (1963) Fiber projections from the nucleus caudalis of the spinal trigeminal nucleus. J Comp Neurol 121: 271–286
Trevino DL, Maunz RA, Bryan RN, Willis WD (1972) Location of cells of origin of the spinothalamic tract in the lumbar enlargement of the cat. Exp Neurol 34: 64–77
Willis WD, Coggeshall RE (1978) Sensory mechanisms of the spinal cord. John Wiley, Chichester
Supported by MRC and INSERM PRC 120034
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Dickenson, A.H., Le Bars, D. Diffuse noxious inhibitory controls (DNIC) involve trigeminothalamic and spinothalamic neurones in the rat. Exp Brain Res 49, 174–180 (1983). https://doi.org/10.1007/BF00238577
- Spinothalamic neurones
- Trigeminothalamic neurones
- Diffuse noxious inhibitory controls