Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Cerebellar Purkyně cell responses to inputs from sensorimotor cortex

  • 38 Accesses

  • 1 Citations

Summary

The responses of single Purkyně cells in the pars intermedia of the anterior lobe were studied following stimulation of the sensorimotor cortex in the cat. The cortical inputs display the same kind of mossy fiber and climbing fiber duality as previously described for nerve inputs (Eccles et al., 1971 b). Stimulation of the cerebral cortex elicits short latency excitation (4–8 msec) and inhibition (8–12 msec) via the mossy fiber system and a longer latency climbing fiber excitation (12–19 msec). The response of a Purkyně cell may consist of any combination of these possible components and depends upon the cortical area stimulated. The mossy fiber system is activated by a single shock, is increased by a second volley, and follows relatively high repetition rates. On the other hand, the climbing fiber system has a higher threshold, and only follows repetition rates up to 5–20 Hz. Two or more volleys are needed for efficient transmission.

This is a preview of subscription content, log in to check access.

References

  1. Allen, G.I., Azzena, G.B., Ohno, T.: Contribution of the cerebro-reticulo-cerebellar pathway to the early mossy fibre response in the cerebellar cortex. Brain Res. 44, 670–675 (1972)

  2. Allen, G.I., Azzena, G.B., Ohno, T.: Somatotopically organized inputs from fore and hindlimb areas of sensorimotor cortex to cerebellar Purkyně cells. Exp. Brain Res. 20, 255–272 (1974)

  3. Allen, G.I., Korn, H., Oshima, T.: Monosynaptic pyramidal activation of pontine nuclei cells projecting to the cerebellum. Brain Res. 15, 272–275 (1969)

  4. Armstrong, D.M., Eccles, J.C., Harvey, R.J., Matthews, P.B.C.: Responses in the dorsal accessory olive of the cat to stimulation of hindlimb afferents. J. Physiol. (Lond.) 194, 125–145 (1968)

  5. Armstrong, D.M., Harvey, R.J.: Responses in the inferior olive to stimulation of the cerebellar and cerebral cortices in the cat. J. Physiol. (Lond.) 187, 553–574 (1966)

  6. Berman, A.L.: The Brain Stem of the Cat Madison, Milwaukee, 175 pp. London: University of Wisconsin Press 1968

  7. Bloedel, J.R., Roberts, W.J.: Action of climbing fibers in cerebellar cortex of the cat. J. Neurophysiol. 34, 17–31 (1971)

  8. Brodal, P.: The corticopontine projection in the cat. I. Demonstration of a Somatotopically organized projection from the primary sensorimotor cortex. Exp. Brain Res. 5, 210–234 (1968)

  9. Cervetto, L., Marchesi, G.F., Strata, P.: Electrophysiological investigations on the pathways from cerebral cortex to the anterior lobe of the cerebellum. Arch. ital. Biol. 107, 85–104 (1969)

  10. Crichlow, E.C.: Influence of sensorimotor cortices on lateral reticular nucleus cells. Exp. Neurol. 32, 184–194 (1971)

  11. Crill, W.E.: Unitary multiple-spiked responses in cat inferior olive nucleus. J. Neurophysiol. 33, 199–209 (1970)

  12. Crill, W.E., Kennedy, T.T.: Inferior olive of the cat: Intracellular recording. Science 157, 716–718 (1967)

  13. Deura, S.: Long latency cerebellar responses in cerebellar penduncli and cortex. Neurology 11, 940–949 (1961)

  14. Eccles, J.C.: Circuits in the cerebral control of movement. Proc. nat. Acad. Sci. (Wash.) 58, 336–343 (1967)

  15. Eccles, J.C.: The dynamic loop hypothesis of movement control. In: Information Processing in the Nervous System, pp. 245–269. Ed. by K.N. Leibovic. Berlin-Heidelberg-New York: Springer 1969

  16. Eccles, J.C.: Review lecture. The cerebellum as a computer: patterns in space and time. J. Physiol. (Lond.) 229, 1–32 (1973)

  17. Eccles, J.C., Faber, D.S., Murphy, J.T., Sabah, N.H., Táboříková, H.: Afferent volleys in limb nerves influencing impulse discharges in cerebellar cortex. I. In mossy fibers and granule cells. Exp. Brain Res. 13, 15–35 (1971a)

  18. Eccles, J.C., Faber, D.S., Murphy, J.T., Sabah, N.H., Táboříková, H.: Afferent volleys in limb nerves influencing impulse discharges in cerebellar cortex. II. In Purkyně cells. Exp. Brain Res. 13, 36–53 (1971b)

  19. Eccles, J.C., Faber, D.S., Murphy, J.T., Sabah, N.H., Táboříková, H.: Investigations on integration of mossy fiber inputs to Purkyně cells in the anterior lobe. Exp. Brain Res. 13, 54–77 (1971c)

  20. Eccles, J.C., Ito, M., Szentágothai, J.: The Cerebellum as a Neuronal Machine, 335 pp. Berlin-Heidelberg-New York: Springer 1967

  21. Eccles, J.C., Provini, L., Strata, P., Táboříková, H.: Analysis of electrical potentials evoked in the cerebellar anterior lobe by stimulation of hindlimb and forelimb nerves. Exp. Brain Res. 6, 171–194 (1968a)

  22. Eccles, J.C., Provini, L., Strata, P., Táboříková, H.: Topographical investigations on the climbing fiber inputs from forelimb and hindlimb afferents to the cerebellar anterior lobe. Exp. Brain Res. 6, 195–215 (1968b)

  23. Eccles, J.C., Sabah, N.H., Schmidt, R.F., Táboříková, H.: Cutaneous mechanoreceptors influencing impulse discharges in cerebellar cortex. I. In mossy fibers. Exp. Brain Res. 15, 245–260 (1972a)

  24. Eccles, J.C., Sabah, N.H., Schmidt, R.F., Táboříková, H.: Cutaneous mechanoreceptors influencing impulse discharges in cerebellar cortex. II. In Purkyně cells by mossy fiber inputs. Exp. Brain Res. 15, 261–277 (1972b)

  25. Eccles, J.C., Sabah, N.H., Schmidt, R.F., Táboříková, H.: Cutaneous mechanoreceptors influencing impulse discharges in cerebellar cortex. III. In Purkyně cells by climbing fiber input. Exp. Brain Res. 15, 484–497 (1972c)

  26. Eccles, J.C., Sabah, N.H., Schmidt, R.F., Táboříková, H.: Integration by Purkyně cells of mossy and climbing fiber inputs from cutaneous mechanoreceptors. Exp. Brain Res. 15, 498–529 (1972d)

  27. Iosif, G., Pompeiano, O., Strata, P., Thoden, U.: The effect of stimulation of spindle receptors and Golgi tendon organs on the cerebellar anterior lobe. II. Responses of Purkinje cells to sinusoidal stretch or contraction of hindlimb extensor muscles. Arch. ital. Biol. 110, 502–542 (1972)

  28. Ishikawa, K., Kawaguchi, S., Rowe, M.J.: Actions of afferent impulses from muscle receptors on cerebellar Purkyně cells. I. Responses to muscle vibration. Exp. Brain Res. 15, 177–193 (1972)

  29. Jansen, J., Brodal, A.: Aspects of Cerebellar Anatomy, 423 pp. Oslo: J.G. Tanum 1954

  30. Jansen, J.K.S.: Afferent impulses to the cerebellar hemispheres from the cerebral cortex and certain subcortical nuclei. Acta physiol. scand. 143, Suppl. 41, 1–99 (1957)

  31. Kitai, S.T., Oshima, L., Provini, L., Tsukahara, N.: Cerebro-cerebellar connections mediated by fast and slow conducting pyramidal tract fibres of the cat. Brain Res. 15, 267–271 (1969)

  32. Larsell, O.: The cerebellum of the cat and the monkey. J. comp. Neurol. 99, 135–199 (1953)

  33. Miller, S., Nezlina, N., Oscarsson, O.: Projection and convergence patterns in climbing fibre paths to cerebellar anterior lobe activated from cerebral cortex and spinal cord. Brain Res. 14, 230–233 (1969)

  34. Murphy, J.T., MacKay, W.A., Johnson, F.: Differences between cerebellar mossy and climbing fibre responses to natural stimulation of forelimb muscle proprioceptors. Brain Res. 55, 263–289 (1973)

  35. Murphy, J.T., Sabah, N.H.: Cerebellar Purkinje cell responses to afferent inputs. I. Climbing fiber activation. Brain Res. 25, 449–168 (1971)

  36. Provini, L., Redman, S., Strata, P.: Mossy and climbing fibre organization on the anterior lobe of the cerebellum activated by forelimb and hindlimb areas of the sensorimotor cortex. Exp. Brain Res. 6, 216–233 (1968)

  37. Sousa-Pinto, A., Brodal, A.: Demonstration of a somatotopical pattern in the cortico-olivary projection in the cat. An experimental-anatomical study. Exp. Brain Res. 8, 364–386 (1969)

  38. Takahashi, K.: Slow and fast groups of pyramidal tract cells and their respective membrane properties. J. Neurophysiol. 28, 908–923 (1965)

  39. Thach, W.T., Jr.: Discharge of Purkinje and cerebellar nuclear neurons during rapidly alternating arm movements in the monkey. J. Neurophysiol. 31, 785–797 (1968)

  40. Tsukahara, N., Korn, H., Stone, J.: Pontine relay from cerebral cortex and nucleus interpositus. Brain Res. 10, 448–453 (1968)

  41. Woolsey, C.N.: Organization of somatic sensory and motor areas of the cerebral cortex. In: Biological and Biochemical Bases of Behavior, pp. 63–81. Ed. by H.F. Harlow and C.N. Woolsey. Madison, Wisconsin: University of Wisconsin Press 1958

  42. Zangger, P., Wiesendanger, M.: Excitation of lateral reticular nucleus neurones by collaterals of the pyramidal tract. Exp. Brain Res. 17, 144–151 (1973)

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Allen, G.I., Azzena, G.B. & Ohno, T. Cerebellar Purkyně cell responses to inputs from sensorimotor cortex. Exp Brain Res 20, 239–254 (1974). https://doi.org/10.1007/BF00238315

Download citation

Key words

  • Cerebellum
  • Cerebral cortex
  • Mossy fibers
  • Climbing fibers