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Quantitative studies on the supraoptic nucleus in the rat. II. Afferent fiber connections

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Summary

A quantitative electron microscopic study of synaptic terminal degeneration was performed in the supraoptic nucleus (NSO) after a variety of major transections or ablations, destroying or interrupting in different combinations the afferent pathways known from earlier and own light microscopic degeneration studies. Solutions of a set of equations, expressing the percentage degenerations in synaptic profiles after different combinations in which the several pathways are interrupted by the various interferences, enabled the authors to give the following percentage numbers for afferent synapses from different sources.

32.7% of supraoptic afferents originate from the brain stem probably representing the monoaminergic innervation of this nucleus. The medial basal hypothalamus (21.0%), amygdala (13.5%), septum (13.5%), hippocampus (8.5%) and olfactory tubercle and further rostral cortical region (17.0%) are the other main sites of origin of supraoptic nucleus afferents. There are no supraoptic afferents from the optic nerve, superior cervical ganglion or fimbria hippocampi.

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Abbreviations

A:

nucleus accumbens

AB:

nucleus amygdaloideus basalis

AC:

nucleus amygdaloideus centralis

AL:

nucleus amygdaloideus lateralis

AM:

nucleus amygdaloideus medialis

ATV:

area tegmenti ventralis (Tsai)

C:

caudate-putamen

CA:

commissura anterior

CC:

corpus callosum

CFV:

commissura fornicvis ventralis

CO:

chiasma opticum

CP:

commissura posterior

D:

nucleus tractus diagnolis

DM:

nucleus dorsomedialis

DS:

decussationes supraoptica

F:

columna fornicis

FH:

fimbria hippocampi

FLM:

fasciculus longitudinalis medialis

FP:

fornix praecommissuralis

FS:

fornix superior

G:

globus pallidus

GD:

gyrus dentatus

HI:

hippocampus

IC:

capsula interna

IP:

nucleus interpeduncularis

LM:

lemniscus medialis

M:

medial forebrain bundle (MFB)

MM:

nucleus medialis thalami, pars medialis

NA:

nucleus arcuatus

R:

nucleus rhomboideus

RE:

nucleus reuniens

RV:

nucleus ruber

S:

stria medullaris thalami

SD:

nucleus dorsalis septi

SF:

nucleus fimbrialis septi

SG:

substantia grisea centralis

SL:

nucleus lateralis septi

SM:

nucleus medialis septi

SN:

substantia nigra

ST:

nucleus interstitialis striae terminalis

T:

tractus olfactorius lateralis

TD:

tractus diagonalis (Broca)

TO:

tractus opticus

TSTH:

tractus striohypothalamicus

TU:

tuberculum olfactorium

VM:

nucleus ventromedialis

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Záborszky, L., Léránth, C., Makara, G.B. et al. Quantitative studies on the supraoptic nucleus in the rat. II. Afferent fiber connections. Exp Brain Res 22, 525–540 (1975). https://doi.org/10.1007/BF00237352

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Key words

  • Supraoptic nucleus
  • Quantitative electron microscopy
  • Afferent fiber connections
  • Rat