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Cat red nucleus changes of activity during the motor initiation in a reaction time task

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Summary

Unit recordings were made in the posterior red nucleus of 4 freely moving cats, performing a conditioned forelimb flexion in response to a sound, in a simple reaction time (RT) paradigm. More than 50% of the recorded neurons (154) were found to be task-related, with marked changes of firing (mostly increases) time-locked with the go-signal (mean latency: 40.8 ms ± 12 ms SD) and frequency-correlated with the duration of the RT. These RT-correlated changes of firing disappeared or were markedly decreased when the movement was not triggered. Most of the task-related neurons also displayed late changes of firing during the force change, time-locked with the movement. Furthermore, a clear relation was observed between the rubral firing before and after the go-signal and the sensorimotor field of the recorded neuron: the neurons preferentially related to limb or trunk movements discharged with the highest frequency throughout the conditioned sequence and exhibited the best RT-correlated increases of firing during the movement initiation. In contrast, rubral neurons apparently related to head-movements generally discharged with low frequency and commonly exhibited decreases of firing in the initiation period. The changes of rubral firing prior to the motor activity, correlated to the RTs, suggest a command function for the RN, in the triggering of the conditioned motor response.

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References

  1. Amalric M, Condé H, Dormont JF, Schmied A (1980) Unitary recording and cooling in the interposito-rubral system during a conditioned motor task, in the cat. Neurosci Lett [Suppl] 5: S438

  2. Amalric M, Condé H, Dormont JF, Schmied A (1983) Are coding schemes actually used? The cooling test demonstration. In: Massion J, Paillard J, Schultz W, Wiesendanger M (eds) Neural coding of motor performance. Springer, Berlin Heidelberg New York. Exp Brain Res [Suppl] 7: 204–209

  3. Bénita M, Condé H, Dormont JF, Schmied A (1979) Effects of ventrolateral cooling on initiation of forelimb ballistic flexion movements by conditioned cats. Exp Brain Res 34: 435–452

  4. Brooks VB (1977) The role of the cerebellum in initiation and control of movement. Proceedings of the Union of Physiological Sciences, vol XII. Com Nat Fr Sc Physiol Paris, pp 24–25

  5. Burton JF, Onoda N (1978) Dependence of the activity of interpositus and Red Nucleus neurons on sensory input data generated by movement. Brain Res 152: 41–63

  6. Cheney PD (1980) Response of rubromotoneuronal cells identified by spike-triggered averaging of EMG activity in awake monkeys. Neurosci Lett 17: 137–142

  7. Condé F, Condé H (1980) Demonstration of a rubrothalamic projection in the cat, with some comments on the origin of the rubrospinal tract. Neuroscience 5: 789–802

  8. Condé F, Condé H (1982) The rubro-olivary tract in the cat, as demonstrated with the method of retrograde transport of horseradish peroxidase. Neuroscience 7: 715–724

  9. Condé H, Dormont JF, Schmied A, Bénita M (1978) Scheduled-training of cats to a simple reaction time performance. J Physiol (Paris) 74: 439–446

  10. Eccles JC, Scheid P, Taborikova H (1975) Responses of Red Nucleus neurons to antidromic and synaptic activation. J Neurophysiol 38: 947–964

  11. Fromm C, Evarts EV, Kröller J, Shinoda Y (1981) Activity of Motor cortex and Red Nucleus neurons during voluntary movement. In: Pompeiano O, Ajmone-Marsan C (eds) Brain mechanisms of perceptual awareness and purposeful behavior. International brain research monograph series, vol 8. Raven Press, New York, pp 269–294

  12. Ghez C, Kubota K (1977) Activity of Red Nucleus neurons associated with a skilled forelimb movement in the cat. Brain Res 131: 383–388

  13. Ghez C, Vicario D (1978) Discharge of Red Nucleus during voluntary muscle contraction: Activity patterns and correlations with isometric force. J Physiol (Paris) 74: 283–286

  14. Ghez C, Vicario D, Martin JH, Yumiya H (1983) Sensory motor processing of targeted movements in motor cortex. In: Desmedt JE (ed) Motor control in health and disease. Raven Press, New York (in press)

  15. Giuffrida R, Li Volsi G, Panto MR, Perciavalle V, Sapienza S, Urbano A (1980) Single muscle organization of interpositorubral projections. Exp Brain Res 39: 261–267

  16. Giuffrida R, Licata F, Li Volsi G, Perciavalle V (1982) Motor responses evoked by microstimulation of cerebellar interpositus nucleus in cats submitted to dorsal rhizotomy. Neurosci Lett 30: 241–244

  17. Hoddevick H (1975) The ponto-cerebellar projection onto paramedian lobule in the cat: An experimental study with the use of horseradish peroxydase. Exp Brain Res 95: 291–308

  18. Iuiert M, Lundberg A, Tanaka R (1977) Integration in descending motor pathways controlling the forelimb in the cat: 3. Convergence on propriospinal neurones transmitting disynaptic excitation from the corticospinal tract and other descending tracts. Exp Brain Res 29: 323–348

  19. Jankowska E (1978) Some problems of projections and actions of cortico and rubrospinal fibres. J Physiol (Paris) 74: 209–214

  20. Kawamura K (1975) The pontine projection from the inferior colliculus in the cat. An experimental anatomical study. Brain Res 95: 309–322

  21. Kohlerman NJ, Gibson AR, Houk JC (1982) Velocity signals related to hand movements recorded from Red Nucleus neurons in monkeys. Science 217: 857–859

  22. Larsen KD, Yumiya H (1980) Motor cortical modulation of feline Red Nucleus output: Corticorubral and cerebellar mediated responses. Exp Brain Res 38: 321–331

  23. Massion J (1967) The mammalian Red Nucleus. Physiol Rev 47: 383–436

  24. Orlovsky GN (1972) Activity of rubrospinal neurons during locomotion. Brain Res 46: 99–112

  25. Otero JB (1976) Comparison between Red Nucleus and precentral neurons during learned movement in the monkey. Brain Res 101: 37–46

  26. Otero Costas JB, Lamas AC (1982) Red nucleus activity during ballistic movements. Effect of cerebellar nuclei stimulation. Brain Res 248: 387–391

  27. Padel Y (1973) Le noyau rouge postérieur chez le chat et les primates. La voie cortico-rubro-spinale. Thèse, Université de Paris XI, 195 p

  28. Padel Y, Jeneskog T (1981) Inhibition of rubrospinal cells by somesthetic afferent activity. Neurosci Lett 21: 177–182

  29. Padel Y, Steinberg R (1978) Red Nucleus cell activity in awake cats during a placing reaction. J Physiol (Paris) 74: 265–282

  30. Perciavalle V, Santangelo F, Sapienza S, Savoca F, Urbano A (1977) Motor effects produced by microstimulation of brachium pontis in the cat. Brain Res 126: 557–562

  31. Powell E, Hatton JB (1969) Projections of the inferior colliculus in the cat. J Comp Neurol 136: 183–192

  32. Schmied A, Bénita M, Condé H, Dormont JF (1979) Activity of ventrolateral thalamic neurons in relation to a simple reaction time task in the cat. Exp Brain Res 36: 285–300

  33. Schwindt P (1980) Control of motoneuron output by pathways descending from the Brain Stem. In: Towe AL, Luschei ES (eds) Handbook of behavioral neurobiology, vol 5. Motor coordination. Plenum Press, New York, pp 139–230

  34. Soechting JF, Burton JE, Onoda N (1978) Relationships between sensory input, motor output and unit activity in Interpositus Red Nuclei during intentional movement. Brain Res 152: 365–379

  35. Toyama K, Tsukahara N, Udo M (1967) Nature of cerebellar influence upon the Red Nucleus. Exp Brain Res 4: 292–309

  36. Tsukahara N, Fuller DRG, Brooks VB (1968) Collateral pyramidal influences on the corticorubral system. J Neurophysiol 31: 467–484

  37. Vicario D, Martin JH, Ghez C (1983) Specialized subrogions in the motor cortex: A single unit analysis in the behaving cat. Exp Brain Res 51: 351–367

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Author information

Correspondence to Dr. A. Schmied.

Additional information

Supported by the CNRS (LA 89) and the DGRST (DN P111)

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Amalric, M., Condé, H., Dormont, J.F. et al. Cat red nucleus changes of activity during the motor initiation in a reaction time task. Exp Brain Res 52, 210–218 (1983). https://doi.org/10.1007/BF00236629

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Key words

  • Red nucleus
  • Motor initiation
  • Reaction time
  • Single unit recording