Advertisement

Springer Nature is making Coronavirus research free. View research | View latest news | Sign up for updates

Hippocampal glutamate receptors

  • 36 Accesses

  • 67 Citations

Summary

For years, the hippocampus has been the privileged domain of anatomists and electrophysiologists for investigating various neurobiological processes. The present review deals with recent work which shows that this structure is also well suited to study the role of glutamate as a neurotransmitter and more particularly the characteristics of glutamate receptors and their possible involvement in hippocampal function. After a brief description of the main anatomical features of the hippocampus, we attempt a critical evaluation of the electrophysiological studies of hippocampal glutamate receptors. We then describe the properties of Na-independent 3H-glutamate binding sites in hippocampal membranes, and discuss the possibility that these binding sites are related to postsynaptic glutamate receptors. Finally we show that these binding sites are extremely labile and that hippocampal membranes possess various mechanisms which regulate their number. In particular we develop the idea that the calcium-stimulation of 3H-glutamate binding in hippocampal membranes may be the mechanism by which electrical activity regulates the number of glutamate receptors at hippocampal synapses and thus induces long-lasting changes in synaptic transmission.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Fonnum, F., Ed., 1978. Amino Acids as Chemical Transmitters, Plenum Press, New York.

  2. 2.

    Usherwood, P. N. R., 1978. Advances in Comp. Physiol. and Biochem. 1: 227–309.

  3. 3.

    Johnson, J. L., 1978. Prog. in Neurobiol. 10: 155–202.

  4. 4.

    Roberts, P. J., Storm-Mathisen, J. & Johnston, G., Eds., 1980. Glutamate as a Transmitter, John Wiley Press, New York.

  5. 5.

    DiChiara, G. & Gessa, G. L., Eds., 1980. Glutamate as a Neurotransmitter, Raven Press, New York.

  6. 6.

    Nadler, J. V., Vaca, K. V., White, W. F., Lynch, G. S. & Cotman, C. W., 1976. Nature 260: 538–540.

  7. 7.

    Wieraszko, A. & Lynch, G., 1979. Brain Res. 160: 372–376.

  8. 8.

    Baudry, M. & Lynch, G., 1979. Europ. J. Pharmacol. 57: 283–285.

  9. 9.

    Baudry, M. & Lynch, G., 1981. J. Neurochem. 36: 811–820.

  10. 10.

    Lynch, G. & Cotman, C. W., 1975. In: The Hippocampus (Isaacson, R. & Pribram, K., eds.), Vol. I, pp. 123–155, Plenum Publishing Co., New York.

  11. 11.

    Lynch, G., Rose, G. & Gall, C., 1978. In: Functions of the Septohippocampal System, Ciba Foundation Symposium, Vol. 58, pp. 5–24, Elsevier, North-Holland.

  12. 12.

    Storm-Mathisen, J., 1972. Brain Res. 40: 215–235.

  13. 13.

    Gall, C., Brecha, N., Chang, T. & Karten, H., 1981. J. Comp. Neurol., in press.

  14. 14.

    Biscoe, T. J. & Straughan, D., 1966. J. Physiol. 183: 341–359.

  15. 15.

    Spencer, H. J., Gribkoff, V. U., Cotman, C. M. & Lynch, G., 1976. Brain Res. 105: 471–481.

  16. 16.

    Hicks, T. P. & McLennan, H., 1979. Can. J. Physiol. Pharmacol. 57: 973–978.

  17. 17.

    Wheal, H. V. & Miller, J. J., 1980. Brain Res. 182: 145–155.

  18. 18.

    Segal, M., 1980. In Glutamate as a Neurotransmitter (DiChiara, G. & Gessa, G. L., eds.) pp. 217–226 Raven Press, New York.

  19. 19.

    Curtis, D. R., Duggan, A. W., Felix, D., Johnston, G. A. R. & McLennan, H., 1971. Brain Res. 33: 57–73.

  20. 20.

    White, W. F., Nadler, J. V. & Cotman, C. W., 1979. Brain Res. 164: 177–194.

  21. 21.

    Dunwiddie, T. V., Madison, D. & Lynch, G. S., 1978. Brain Res. 150: 413–417.

  22. 22.

    Limbird, L. E. & Lefkowitz, R. J., 1976. Molec. Pharmacol. 12: 559–567.

  23. 23.

    Ferrendelli, J. A., Chang, M. M. & Kinscherf, D. A., 1974. J. Neurochem. 22: 535–540.

  24. 24.

    Garthwaite, J. & Balazs, R., 1980 in Glutamate as a Neurotransmitter (DiChiara, G. & Gessa, G. L., eds.) pp. 317–326, Raven Press, New York.

  25. 25.

    Kasai, M. & Changeux, J. P., 1971. J. Memb. Biol. 6: 1–16.

  26. 26.

    Luini, A., Goldberg, D. & Teichberg, V. I., 1980. Abstract Society for Neuroscience, v. 10, p. 189.

  27. 27.

    Hollenberg, M. D. & Cuatrecasas, P., 1979 in The Receptors (O'Brien, R. D., ed.) vol. I, pp. 193–213.

  28. 28.

    Roberts, P. J., 1976. Nature 252: 399–401.

  29. 29.

    Michaelis, E. K., 1975. Biochem. Biophys. Res. Comm. 65: 1004–1012.

  30. 30.

    Michaelis, E. K., Michaelis, M. L. & Boyarsky, L. L., 1974. Biochim. Biophys. Acta 367: 338–348.

  31. 31.

    De Robertis, E. & Fiszer De Plazas, S., 1976. J. Neurochem. 26: 1237–1243.

  32. 32.

    Foster, A. C. & Roberts, P. J., 1978. J. Neurochem. 31: 1467–1477.

  33. 33.

    De Barry, J., Vincendon, G. & Gombos, G., 1980. FEBS Letters 109: 175–179.

  34. 34.

    Biziere, K., Thompson, H. & Coyle, J. T., 1980. Brain Res. 183: 421–433.

  35. 35.

    Simon, J. P., Contrera, J. F. & Kuhar, M. J., 1976. J. Neurochem. 26: 141–147.

  36. 36.

    Schwarcz, R. Scholz, D. & Coyle, J. T., 1978. Neuropharmacology 17: 147–151.

  37. 37.

    Coyle, J. T., Zaczek, R., Slevin, J. & Collins, J., 1980 in Glutamate as a Neurotransmitter (DiChiara, G. & Gessa, G. L., eds.) pp. 337–346, Raven Press, New York.

  38. 38.

    Enna, S. J. & Snyder, W. H., 1977. Mol. Pharmacol. 13: 442–453.

  39. 39.

    Vincent, S. R. & McGeer, E., 1980. Brain Res. 184: 99–108.

  40. 40.

    Baudry, M. & Lynch, G., 1979. Nature 282: 748–750.

  41. 41.

    Anderson, C. R., Cull-Candy S. G. & Miledi, R., 1976. Nature 261: 151–153.

  42. 42.

    Mohler, H. & Okada, T., 1978. Mol. Pharmacol. 14: 256–265.

  43. 43.

    Young, A. B. & Snyder, S. H., 1974. Proc. Nat. Acad. Sci. (USA) 71: 4002–4005.

  44. 44.

    O'Brien, R. D., 1979 in The Receptors (O'Brien, R. D., ed.), vol. 1, pp. 311–333, Plenum Press, New York.

  45. 45.

    Wheeler, D. D., 1979. J. Neurochem. 33: 883–894.

  46. 46.

    Fonnum, F., Lund-Karlsen, R., Malthe-Sorensen, D., Skrede, K. K. & Walaas, I., 1979. Prog. Brain Res. 51: 167–191.

  47. 47.

    Baudry, M., Arst, D., Oliver, M. & Lynch, G., 1981. Developmental Brain Res. 1: 37–48.

  48. 48.

    Gall, C., McWilliams, R. & Lynch, G., 1980. J. Comp. Neur., 193: 1047–1062.

  49. 49.

    Loy, R., Lynch, G. & Cotman, C., 1977. Brain Res. 121: 229–243.

  50. 50.

    Loy, R., 1980. Anat. and Embryol. 159: 257–275.

  51. 51.

    Schlessinger, A. R., Cowan, W. M. & Gottlieb, D. I., 1975. J. Comp. Neurol. 159: 149–176.

  52. 52.

    Cotman, C. W., Foster, A. & Lanthorn, T., 1980 in Glutamate as a Neurotransmitter (DiChiara, G. & Gessa, G. L., eds.) pp. 1–27, Raven Press, New York.

  53. 53.

    Bliss, T. V. P. & Lomo, T., 1973. J. Physiol. (Lond.) 232: 331–356.

  54. 54.

    Bliss, T. V. P. & Gardner-Medwin, A. T., 1973. J. Physiol. (Lond.) 232: 357–374.

  55. 55.

    Lynch, G., Gall, C. & Dunwiddie, T., 1973. In: Progress in Brain Research (Corner, M. A., ed.) pp. 113–128, Elsevier Scientific Publishing Co., Amsterdam.

  56. 56.

    Nicolson, G. L., 1979. Curr. Top. Dev. Biol. 13: 305–338.

  57. 57.

    Dunwiddie, T. V. & Lynch, G. S., 1978. J. Physiol. (Lond.) 276: 353–367.

  58. 58.

    Finn, R., Browning, M. & Lynch, G., 1980. Neuroscience Letters 19: 103–108.

  59. 59.

    Baudry, M. & Lynch, G., 1980. Proc. Nat. Acad. Sci. (USA) 77: 2298–2302.

  60. 60.

    Toyo-Oka, T., Shimizu, T. & Masaki, T., 1978. Biochem. Biophys. Res. Commun. 82: 484–491.

  61. 61.

    Vargas, F., Greenbaum, L. & Costa, E., 1980. Neuropharmacology 19: 791–794.

  62. 62.

    Baudry, M., Bundman, M., Smith, E. & Lynch, G., 1981. Science, in press.

  63. 63.

    Gilbert, D. S., Newby, B. J. & Anderton, B. H., 1975. Nature 256: 586–589.

  64. 64.

    Schlaepfer, W. W. & Hasler, M. B., 1979. Brain Res. 168: 299–309.

  65. 65.

    Pant, H. C. & Gainer, H., 1980. J. Neurobiol. 11: 1–12.

  66. 66.

    Cohen, R. S., Blomberg, F., Berins, K. & Siekevitz, P., 1977. J. Cell Biol. 74: 181–191.

  67. 67.

    Wigstrom, H. & Swann, J. W., 1980. Brain Res. 194: 181–191.

  68. 68.

    Harris, K. M., Teyler, T. M. & Cruce, W. L. R., 1980. Abstracts Society for Neuroscience vol. 10, p. 86.

  69. 69.

    Baudry, M., Oliver, M., Creager, R., Wierszko, A. & Lynch, G., 1980. Life Sci. 27: 325–330.

  70. 70.

    Baudry, M. & Lynch, G., 1980. Exp. Neurol. 68: 202–204.

  71. 71.

    Lynch, G. & Baudry, M., 1981. Proceedings of the Meeting ‘Brain Synaptic Plasticity’ Philadelphia, October 1980.

  72. 72.

    Hotson, J. R., Prince, D. A. & Schwartzkroin, P. A., 1979. J. Neurophysiol. 42: 889–895.

  73. 73.

    Wong, R. K. S., Prince, D. A. & Basbaum, A.I., 1979. Proc. Nat. Acad. Sci. (USA) 76: 986–990.

  74. 74.

    Changeux, J. P. & Danchin, A., 1976. Nature 264: 705–712.

  75. 75.

    Lee, K., Schottler, F., Oliver, M. & Lynch, G., 1980. J. Neurophysiol. 44: 247–258.

  76. 76.

    Edelman, G. M., 1976. Science 192: 218–226.

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Baudry, M., Lynch, G. Hippocampal glutamate receptors. Mol Cell Biochem 38, 5–18 (1981). https://doi.org/10.1007/BF00235685

Download citation

Keywords

  • Glutamate
  • Critical Evaluation
  • Glutamate Receptor
  • Electrical Activity
  • Synaptic Transmission