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Effects of serial lesions of somatosensory cortex and further neodecortication on retention of a rough-smooth discrimination in rats

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Summary

Five groups of rats with bilateral lesions of the somatosensory cortex and one of animals sustaining only sham operations were tested for retention of a rough-smooth discrimination. Two of the lesion groups had sequential unilateral ablations, in one case with interoperative testing, and three groups had one-stage bilateral lesions. The two groups of animals with serial lesions did not differ from each other or from sham operates in relearning the task. Rats with one-stage lesions and preoperative overtraining also performed well, but the other one-stage groups showed deficits relative to control and serial lesion groups. In the second experiment the sham operated rats from Experiment 1 experienced lesions anterior and posterior to the somatosensory zones. These lesions did not affect retention. Somatosensory cortex then was ablated in one operation and severe performance decrements were seen. Removal of additional neocortex in a sample of animals that had relearned the discrimination after one-stage somatosensory cortex lesions (Exp. 1) also affected retention. In contrast, retention was not impaired on some of the measures in those animals that originally had two-stage ablations. The findings from these two experiments show that some ablation effects can be circumvented with overtraining or serial lesion techniques. The data also indicate that non-somatosensory cortex may play a role in recovery after somatic cortex lesions, but that the substrates underlying recovery might, not be the same after one-stage and two-stage ablations.

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References

  1. Finger, S.: Recovery after somatosensory forebrain damage. In: Plasticity and recovery of function in the central nervous system, pp. 237–264 (ed. D.G. Stein et al.). New York: Academic Press 1974

  2. Finger, S., Frommer, G.P.: Effects of cortical lesions on tactile discriminations graded in difficulty. Life Sci. 7, 897–904 (1968)

  3. Finger, S., Marshak, R.A., Cohen, M., Scheff, S., Trace, R., Neimand, D.: Effects of successive and simultaneous lesions of somatosensory cortex on tactile discrimination in the rat. J. comp. physiol. Psychol. 77, 221–227 (1971)

  4. Finger, S., Walbran, B., Stein, D.G.: Brain damage and behavioral recovery: Serial lesion phenomena. Brain Res. 63, 1–18 (1973)

  5. Glendenning, R.L.: Effects of training between two unilateral lesions of visual cortex upon ultimate retention of black-white discrimination habits by rats. J. comp. physiol. Psychol. 80, 216–229 (1972)

  6. Isaacson, R.L., Schmaltz, L.W.: Failure to find savings from spaced, two-staged destruction of hippocampus. Commun. Behav. Biol. 1, 353–359 (1968)

  7. Kircher, K.A., Braun, J.J., Meyer, D.R., Meyer, P.M.: Equivalence of simultaneous and successive neocortical ablations in production of impairments in retention of black-white habits in rats. J. comp. physiol. Psychol. 71, 420–425 (1970)

  8. LeVere, T.E.: Recovery of function after brainstem lesions in the rat. J. comp. physiol. Psychol. 69, 339–344 (1969)

  9. Meyer, D.R., Isaac, W., Maher, B.: The role of stimulation in spontaneous reorganization of visual habits. J. comp. physiol. Psychol. 51, 546–548 (1958)

  10. Petrinovich, L., Bliss, C.: Retention of a learned brightness discrimination following ablations of the occipital cortex in the rat. J. comp. physiol. Psychol. 61, 136–138 (1966)

  11. Petrinovich, L., Carew, T.J.: Interaction of neocortical lesion size and interoperative experience in retention of a learned brightness discrimination. J. comp. physiol. Psychol. 68, 451–454 (1969)

  12. Semmes, J.: Somesthetic effects of damage to the central nervous system. In: Handbook of sensory physiology, Part 2, Somatosensory system. pp. 714–742. (ed. A. Iggo). Berlin-Heidelberg-New York: Springer 1973

  13. Siegel, S.: Nonparametric statistics for the behavioral sciences. New York: McGraw-Hill 1956

  14. Simons, D., Puretz, J., Finger, S.: Effects of serial lesions of Somatosensory cortex and further neodecortication on tactile retention in rats. Exp. Brain Res. 23, 353–366 (1975)

  15. Sperry, R.W.: Preservation of high-order function in isolated somatic cortex in callosum-sectioned cat. J. Neurophysiol. 22, 78–87 (1959)

  16. Stein, D.G., Firl, A.: Failure to find recovery of function after 2-stage frontal lesions in aged rats. Paper presented at Annual Meetings of Society for Neuroscience. St. Louis, Missouri, October 1974

  17. Stewart, J.W., Ades, H.W.: The time factor in reintegration of a learned habit lost after temporal lobe lesions in the monkey (Macaca mulatta). J. comp. physiol. Psychol. 44, 479–486 (1951)

  18. Thompson, R.: Retention of a brightness discrimination following neocortical damage in the rat. J. comp. physiol. Psychol. 53, 212–215 (1960)

  19. Walbran, B.: Age and serial ablations of somatosensory cortex in the rat. Physiol. Behav. (In press)

  20. Weese, G.D., Neimand, D., Finger, S.: Cortical lesions and somesthesis in rats: Effects of training and overtraining prior to surgery. Exp. Brain Res. 16, 542–550 (1973)

  21. Welker, C.: Microelectrode delineation of fine grain somatotopic organization of Sml cerebral neocortex in albino rat. Brain Res. 26, 259–275 (1971)

  22. Zubek, J.P.: Recent electrophysiological studies of the cerebral cortex: Implications for localization of sensory function. Canad. J. Psychol. 5, 110–121 (1951)

  23. Zubek, J.P.: Studies in somesthesis, III. Role of somatic areas I and II in roughness discrimination in the rat. Canad. J. Psychol. 6, 183–193 (1952)

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Finger, S., Simons, D. Effects of serial lesions of somatosensory cortex and further neodecortication on retention of a rough-smooth discrimination in rats. Exp Brain Res 25, 183–197 (1976). https://doi.org/10.1007/BF00234902

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Key words

  • Somatosensory
  • Lesion
  • Somesthesis
  • Somatic Cortex
  • Discrimination
  • Serial Lesions
  • Learning
  • Recovery of Function