The localization of pancreatic polypeptide (PP) cells was studied in the pancreas of four human neonates by specific immunocytochemical techniques. PP cells were detected in all parts of the pancreas. However, examination at low magnification showed that they were considerably more numerous in a small lobe, located at the posterior-inferior part of the head region. It is suggested that this lobe corresponds to the part of the pancreas that is derived from the ventral primordium. Both in the lobe rich in PP cells and in the remainder of the pancreas, approximately 75% of PP cells were present in the islets and 25% distributed among acini and ducts.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Adrian, T.E., Besterman, H.S., Mallinson, C.N., Greenberg, G.R., Bloom, R.: Inhibition of secretistimulated pancreatic secretion by pancreatic polypeptide. Gut, 20, 37–40 (1979)
Baetens, D., De Mey, J., Gepts, W.: Immunohistochemical and ultrastructural identification of the pancreatic polypeptide-producing cell (PP-cell) in the human pancreas. Cell Tissue Res. 185, 239–246 (1977)
Bergström, B.H., Loo, S., Hirch, H.J., Schutzengel, D., Gabbay, K.H.: Ultrastructural localization of pancreatic polypeptide in human pancreas. J. Clin. Endocrinol. 44, 795–798 (1977)
Forssmann, W.G., Helmstaedter, V., Metz, J., Greenberg, J., Chance, R.E.: The identification of the F-cell in the dog pancreas as the pancreatic polypeptide producing cell. Histochemistry 50, 281–290 (1977)
Gersell, D.J., Gingerich, R.L., Greider, M.H.: Regional distribution and concentration of pancreatic polypeptide in the human and canine pancreas. Diabetes 22, 11–15 (1979)
Graham, R.C., Karnovsky, M.J.: The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: Ultrastructural cytochemistry by a new technique. J. Histochem. Cytochem., 14, 291–302 (1966)
Hamilton, V.J., Boyd, J.D., Mossman, H.W.: Human Embryology (P. 208), Cambridge: Heffer & Sons (1962)
Heitz, Ph., Polak, J.M., Bloom, S.R., Pearse, A.G.E.: Identification of the D1-cell as the source of human pancreatic polypeptide (HPP). Gut, 17, 755–758 (1976)
Kimmel, J.R., Pollock, H.G., Hazelwood, R.L.: Isolation and characterization of chicken insulin. Endocrinology 83, 1323–1330 (1968)
Larsson, L.I., Sundler, F., Håkanson, R.: Immunohistochemical localization of human pancreatic polypeptide (HPP) to a population of islet cells. Cell Tissue Res., 156, 167–171 (1975)
Larsson, L.I., Sundler, F., Håkanson, R.: Pancreatic polypeptide-a postulated new hormone: Identification of its cellular storage site by light and electron microscopic immunocytochemistry. Diabetologia, 12, 211–226 (1976)
Lin, T.M., Chance, R.E.: Spectrum gastrointestinal actions of a new bovine pancreas polypeptide (BPP). Gastroenterology 62, 852 (Abs) (1972)
Lin, T.M., Chance, R.E.: Gastrointestinal actions of a new bovine pancreatic polypeptide (BPP). Endocrinology of the Gut (W.Y. Chey, F.F. Brooks, eds.), pp. 143–145, New Jersey: C.B. Slack (1974)
Lin, T.M., Chance, R.E., Evans, D.C.: Stimulatory and inhibitory actions of a bovine pancreatic peptide (BPP) on gastric and pancreatic secretions of dogs. Gastroenterology, 64, 865 (Abs) (1973)
Lin, T.M., Evans, D.C., Chance, R.E.: Action of a bovine pancreatic polypeptide (BPP) on pancreatic secretion in dogs. Gastroenterology 66, 852 (Abs) (1974)
Malaisse-Lagae, F., Orci, L., Perrelet, A.: Anatomic and hormonal markers for the ventral primordium in the human pancreas. N. Engl. J. Med., 300, p. 436 (1979)
Orci, L., Baetens, D., Ravazzola, M., Stefan, Y., Malaisse-Lagae, F.: Pancreatic polypeptide and glucagon: Non-random distribution in pancreatic islets. Life Sciences, 19, 1811–1816 (1976)
Paulin, C., Dubois, P.M.: Immunohistochemical identification and localization of pancreatic polypeptide cells in the pancreas and gastrointestinal tract of the human fetus and adult man. Cell Tissue Res., 188, 251–257 (1978)
Sternberger, L.R.: Immunocytochemistry. Englewood Cliffs, New Jersey: Prentice-Hall, Inc. (1974)
Sternberger, L.R., Hardy, P.H., Cuculis, J.J., Meyer, H.G.: The unlabeled antibody enzyme method of immunohistochemistry. Preparation and properties of soluble antigen antibody complex (horseradish peroxidase — antihorseradish peroxidase) and its use in the identification of spirochetes. J. Histochem. Cytochem., 18, 315–333 (1970)
Testut, L., Latarjet, A.: Traité d'Anatomie Humaine, 4, 712–713 (1949). Editeurs: G. Doin & Cie, 8 Place de l'Odèon, Paris (6e). 9th Edition.
The authors thank Mrs. S. Vandeputte-Loozen for skilled assistance, Mrs. E. Rausch-Vaes for careful typewriting and Dr. J.C. Henquin for advice and critical reading of the manuscript.
About this article
Cite this article
Rahier, J., Wallon, J., Gepts, W. et al. Localization of pancreatic polypeptide cells in a limited lobe of the human neonate pancreas: Remnant of the ventral primordium?. Cell Tissue Res. 200, 359–366 (1979). https://doi.org/10.1007/BF00234848
- Pancreatic polypeptide cells
- Human neonate
- Pancreatic ventral primordium