Advertisement

Springer Nature is making Coronavirus research free. View research | View latest news | Sign up for updates

Organization of group I activated cells in the main and external cuneate nuclei of the cat: Identification of muscle receptors

  • 51 Accesses

  • 9 Citations

Summary

Extracellular recording was made from 77 primary afferent fibres, 106 cells in the external cuneate nucleus, and 60 cells in the main cuneate nucleus, all activated by slowly adapting muscle stretch receptors. The nature of the muscle receptors responsible for the activation was determined by various types of receptor stimulation.

Primary group I afferents from muscle spindles and tendon organs in distal forelimb muscles showed complete overlap of conduction velocities and thresholds to electrical stimulation. Both types of group I afferents as well as group II muscle spindle afferents were shown to ascend through the dorsal funiculus to the level of the cuneate nuclei.

Three groups of cells were identified in the external cuneate nucleus, activated by group I muscle spindle afferents, tendon organ afferents and group II muscle spindle afferents, respectively.

Almost all group I activated cells in the main cuneate nucleus, including all 34 cells identified as cuneo-thalamic relay cells, received their afferent input from muscle spindle afferents. Three cells were activated by tendon organ afferents.

This is a preview of subscription content, log in to check access.

References

  1. Appelberg, B., Molander, C.: A rubro-olivary pathway. I. Identification of a descending system for control of the dynamic sensitivity of muscle spindles. Exp. Brain Res. 3, 372–381 (1967).

  2. Barker, D.: The structure and distribution of muscle receptors. Symposium on Muscle Receptors. Ed. by Barker, D., pp. 227–240. Hong Kong: Hong Kong University Press 1962.

  3. —: The innervation of the mammalian skeletal muscle. Myotatic Kinesthetic and Vestibular Mechanisms. Ciba Symposium. Ed. by de Reuck, A.V.S. and Knight, J.J.A., pp. 3–15. London: Churchill Ltd. 1966.

  4. Brodal, A.: Die Verbindungen des Nucleus cuneatus externus mit dem Kleinhirn beim Kanichen und bei der Katze. Experimentelle Untersuchungen. Z. ges. Neurol. Psychiat. 171, 167–199 (1941).

  5. Brown, M.C., Engberg, I., Matthews, P.B.C.: The relative sensitivity to vibration of muscle receptors of the cat. J. Physiol. (Lond.) 192, 773–800 (1967).

  6. Burgess, P.R., Clark, F.J.: Dorsal column projection of fibres from the cat knee joint. J. Physiol. (Lond.) 203, 301–315 (1969).

  7. Cooke, J.D., Larson, B., Oscarsson, O., Sjölund, B.: Origin and termination of cuneocerebellar tract. Exp. Brain Res. 13, 339–358 (1971a).

  8. —: Organization of afferent connections to cuneocerebellar tract. Exp. Brain Res. 13, 359–377 (1971b).

  9. Coppin, C.M.L., Jack, J.J.B., McIntyre, A.K.: Properties of group I afferent fibres from semitendinosus muscle in the cat. J. Physiol. (Lond.) 203, 45–46P (1969).

  10. Ferraro, A., Barrera, S.E.: The nuclei of the posterior funiculi in Macacus rhesus. An anatomic and experimental investigation. Arch. Neurol. Psychiat. (Chic.) 33, 262–275 (1935).

  11. Granit, R.: The basis of motor control. 346 pp. London and New York: Academic Press 1970.

  12. — Skoglund, S., Thesleff, S.: Activation of muscle spindles by succinylcholine and decamethonium. The effects of curare. Acta physiol. scand. 28, 134–151 (1953).

  13. — Van der Meulen, J.P.: The pause during contraction in the discharge of the spindle afferents from primary end organs in the cat extensor muscles. Acta physiol. scand. 55, 231–244 (1962).

  14. Grant, G.: Projection of the external cuneate nucleus onto the cerebellum in the cat: An experimental study using silver methods. Exp. Neurol. 5, 179–195 (1962).

  15. Holmqvist, B., Oscarsson, O., Rosén, I.: Functional organization of the cuneocerebellar tract in the cat. Acta physiol. scand. 58, 216–235 (1963).

  16. Houk, J., Henneman, E.: Responses of Golgi tendon organs to active contraction of the soleus muscle of the cat. J. Neurophysiol. 30, 466–481 (1967).

  17. Hunt, C.C.: Relation of function to diameter in afferent fibers of muscle nerves. J. gen. Physiol. 38, 117–131 (1954).

  18. — Kuffler, S.W.: Stretch receptor discharges during muscle contraction. J. Physiol. (Lond.) 113, 298–315 (1951).

  19. — McIntyre, A.K.: Characteristics of responses from receptors from the flexor longus digitorum muscle and the adjoining interosseous region of the cat. J. Physiol. (Lond.) 153, 74–87 (1960).

  20. Jansen, J.K.S., Rudjord, T.: On the silent period and Golgi tendon organs of the soleus muscle of the cat. Acta physiol. scand. 62, 364–379 (1964).

  21. —: Dorsal spinocerebellar tract: response pattern of nerve fibres to muscle stretch. Science 149, 1109–1111 (1965).

  22. — Walløe, L.: Transmission of signals from muscle stretch receptors to the dorsal spinocerebellar tract. The Cerebellum in Health and Disease. Ed. by Fields, W.S. and Willis, W.D., pp. 143–171. St. Louis: Warren H. Green 1970.

  23. Johnson, J.I., Jr., Welker, W.I., Pubols, B.H., Jr.: Somatotopic organization of racoon dorsal column nuclei. J. comp. Neurol. 132, 1–44 (1968).

  24. Landgren, S., Silfvenius, H.: Projection to cerebral cortex of group I muscle afferents from the cat's hindlimb. J. Physiol. (Lond.) 200, 353–372 (1969).

  25. Laporte, Y., Bessou, P.: Etude des sous-groupes lent et rapide du groupe I (fibres afferentes d'origine musculaire de grand diamètre) chez le chat. J. Physiol. (Paris) 49, 1025–1037 (1957).

  26. Lloyd, D.P.C., McIntyre, A.K.: Dorsal column conduction of group I muscle afferent impulses and their relay through Clarke's column. J. Neurophysiol. 13, 39–54 (1950).

  27. Lundberg, A., Oscarsson, O.: Functional organization of the dorsal spino-cerebellar tract in the cat. IV. Synaptic connections of afferents from Golgi tendon organs and muscle spindles. Acta physiol. scand. 38, 53–75 (1956).

  28. — Winsbury, G.: Selective adequate activation of large afferents from muscle spindles and Golgi tendon organs. Acta physiol. scand. 49, 155–164 (1960a).

  29. —: Functional organization of the dorsal spino-cerebellar tract. VI. Further experiments on excitation from tendon organ and muscle spindle afferents. Acta physiol. scand. 49, 165–170 (1960b).

  30. Matthews, B.H.C.: Nerve endings in mammalian muscle. J. Physiol. (Lond.) 78, 1–53 (1933).

  31. Matthews, P.B.C.: The reflex excitation of the soleus muscle of the decerebrate cat caused by vibration applied to its tendon. J. Physiol. (Lond.) 184, 450–472 (1966).

  32. McIntyre, A.K.: Central projection of impulses from receptors activated by muscle stretch. Symposium on muscle receptors. Ed. by Barker, D., pp. 19–29. Hong Kong: Hong Kong University Press 1962.

  33. Oscarsson, O., Rosén, I.: Projection to cerebral cortex of large muscle spindle afferents in forelimb nerves of the cat. J. Physiol. (Lond.) 169, 924–945 (1963).

  34. Petit, D., Burgess, P.R.: Dorsal column projection of receptors in cat hairy skin supplied by myelinated fibres. J. Neurophysiol. 31, 849–855 (1968).

  35. Rexed, B., Ström, G.: Afferent nervous connexions of the lateral cervical nucleus. Acta physiol. scand. 25, 219–229 (1952).

  36. Rosén, I.: Localization in caudal brain stem and cervical spinal cord of neurones activated from forelimb group I afferents in the cat. Brain Res. 16, 55–71 (1969a).

  37. — Afferent connexions to group I activated cells in the main cuneate nucleus of the cat. J. Physiol. (Lond.) 205, 209–236 (1969b).

  38. Rosén, I. Projection of forelimb group I muscle afferents to the cat cerebral cortex. Lund: Thesis 1970.

  39. — Sjölund, B.: Natural stimulation of group I activated cells in the cuneate nuclei of the cat. Acta physiol. scand. Suppl. 330, 118 (1969).

  40. —: Organization of group I activated cells in the main and external cuneate nuclei of the cat: Convergence patterns demonstrated by natural stimulation. Exp. Brain Res. 16, 238–246 (1973).

  41. Silfvenius, H.: Characteristics of receptors and afferent fibres of the forelimb interosseous nerve of the cat. Acta physiol. scand. 79, 6–23 (1970).

  42. —: Projections to the cerebral cortex from afferents of the interosseous nerves of the cat. Acta physiol. scand. 80, 196–214 (1970b).

  43. Stuart, D.G., Goslow, G.E., Mosher, C.G., Reinking, R.M.: Stretch responsiveness of Golgi tendon organs. Exp. Brain Res. 10, 463–476 (1970).

  44. Uddenberg, N.: Differential localization in dorsal funiculus of fibres originating from different receptors. Exp. Brain Res. 4, 367–376 (1968).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Rosén, I., Sjölund, B. Organization of group I activated cells in the main and external cuneate nuclei of the cat: Identification of muscle receptors. Exp Brain Res 16, 221–237 (1973). https://doi.org/10.1007/BF00233327

Download citation

Key words

  • Main cuneate nucleus
  • External cuneate nucleus
  • Muscle stretch receptors
  • Natural stimulation
  • Cat