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The inositol 1,4,5-trisphosphate (InsP3) receptor

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Conclusion

In this review, we have described the functional properties and regulation of the InsP3R. Not all aspects of InsP3R function and regulation were covered, the main focus was on the most recent and physiologically important data. Information about the structure, heterogeneity, functional properties, and regulation of the InsP3R is useful for understanding the spatiotemporal aspects of Ca signaling. The combination of biochemical, biophysical and molecular biological techniques has revealed the intricacies of the InsP3R over the past decade. However, questions about the functional differences between various isoforms and splice variants of the InsP3R, the structural determinants responsible for regulation of InsP3R by Ca and ATP, the functional effects of InsP3R phosphorylation and many others remain to be elucidated. Future investigations can be expected to provide answers to these important questions.

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We thank S. Bezprozvannaya for expert technical assistance. This work was supported by National Institutes of Health grants HL 33026 and GM 39029, and a Grant-in-Aid from the Patrick and Catherine Weldon Donaghue Medical Research Foundation.

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Bezprozvanny, I., Ehrlich, B.E. The inositol 1,4,5-trisphosphate (InsP3) receptor. J. Membarin Biol. 145, 205–216 (1995). https://doi.org/10.1007/BF00232713

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Key words

  • Intracellular calcium release channel
  • Calcium signaling
  • Second messenger
  • Ryanodine receptor