Although adaptive plasticity is a wellknown feature of the vestibulo-ocular reflex (VOR), deficits in VOR performance after unilateral labyrinthectomy are poorly compensated in a large percentage of cats. To assess whether VOR plastic capabilities are affected by labyrinthectomy, forced oscillation in front of a patterned surround was imposed in unilaterally labyrinthectomized cats. This experimental paradigm has been shown to be very effective in inducing adaptive VOR gain changes in intact animals. We demonstrate that plasticity of VOR gain is still present both in acute and chronic stages following vestibular lesions. By contrast, forced oscillation did not significantly alter the lesion-induced asymmetry of responses. We conclude that VOR gain control mechanisms are not used to their fullest possible extent in a large percentage of animals suffering unilateral vestibular damage.
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Baarsma EA, Collewijn H (1974) Vestibulo-ocular and optokinetic reactions to rotation and their interaction in the rabbit. J Physiol 238: 603–625
Baarsma EA, Collewijn H (1975) Changes in compensatory eye movements after unilateral labyrinthectomy in the rabbit. Arch Otorhinolaryngol 211: 219–230
Baloh RW, Yee RD, Kimm J, Honrubia V (1981) Vestibular-ocular reflex in patients with lesions involving the vestibulocerebellum. Exp Neurol 72: 141–152
Barmack NH (1981) A comparison of the horizontal and vertical vestibulo-ocular reflexes of the rabbit. J Physiol 314: 547–564
Batini C, Ito M, Kado RT, Jastreboff PJ, Miyashita Y (1979) Interaction between the horizontal vestibulo-ocular reflex and optokinetic response in rabbits. Exp Brain Res 37: 1–15
Benson AJ (1970) Interactions between semicircular canals and gravireceptors. In: Douglas EB (ed) Recent advances in aerospace medicine. Reidel Publishing Company, Amsterdam, pp 249–261
Bles W, De Jong JMBV, De Wit G (1984) Somatosensory compensation for loss of labyrinthine function. Acta Otolaryngol 97: 213–221
Cawthrone T (1944) The physiological basis for head exercises. J Chart Soc Physiother 106–107
Collewijn H, Grootendorst AF (1979) Adaptation of optokinetic and vestibulo-ocular reflexes to modified visual input in the rabbit. In: Granit R, Pompeiano O (eds) Reflex control of posture and movement. Progress in Brain Research, Vol 50. Elsevier, Amsterdam, pp 772–781
Cooksey FS (1946) Rehabilitation in vestibular injuries. Proc R Soc Med 39: 273–275
Dichgans J, Bizzi E, Morasso P, Tagliasco V (1973) Mechanisms underlying recovery of eye-head coordination following bilateral labyrinthectomy in monkeys. Exp Brain Res 18: 548–562
Godaux E, Halleux J, Gobert C (1983) Adaptive change of the vestibulo-ocular reflex in the cat: the effects of a long-term frequency-selective procedure. Exp Brain Res 49: 28–34
Ito M, Jastreboff PJ, Miyashita Y (1979) Adaptive modification of the rabbit's horizontal vestibulo-ocular reflex during sustained vestibular and optokinetic stimulation. Exp Brain Res 37: 17–30
Jäger J, Henn V (1981) Habituation of the vestibulo-ocular reflex (VOR) in the monkey during sinusoidal rotation in the dark. Exp Brain Res 41: 108–114
Kasai T, Zee DS (1978) Eye-head coordination in labyrinthine-defective human beings. Brain Res 144: 123–141
Lacour M, Xerri C (1981) Vestibular compensation: new perspectives. In: Flohr H, Precht W (eds) Lesion-induced neuronal plasticity in sensorimotor systems. Springer, Berlin Heidelberg New York, pp 240–253
Lisberger SG, Miles FA, Optican LM (1983) Frequency-selective adaptation: evidence for channels in the vestibulo-ocular reflex. J Neurosci 3: 1234–1244
Maioli C, Precht W, Ried S (1982) Vestibuloocular and optokinetic reflex compensation following hemilabyrinthectomy in the cat. In: Roucoux A, Crommelinck M (eds) Physiological and pathological aspects of eye movements. W Junk Publ, The Hague Boston London, pp 202–208
Maioli C, Precht W, Ried S (1983) Short- and long-term modifications of vestibulo-ocular response dynamics following unilateral vestibular nerve lesions in the cat. Exp Brain Res 50: 259–274
Maioli C, Precht W (1984) The horizontal optokinetic nystagmus in the cat. Exp Brain Res 55: 494–506
Miles FA, Lisberger SG (1981) Plasticity in the vestibulo-ocular reflex: a new hypothesis. Ann Rev Neurosci 4: 273–299
Precht W, Maioli C, Dieringer N, Cochran S (1981) Mechanisms of compensation of the vestibulo-ocular reflex after vestibular neurotomy. In: Flohr H, Precht W (eds) Lesion-induced neuronal plasticity in sensorimotor systems. Springer, Berlin Heidelberg, pp 221–230
Ried S, Maioli C, Precht W (1984) Vestibular nuclear neuron activity in chronically hemilabyrinthectomized cats. Acta Otolaryngol 98: 1–13
Robinson DA (1976) Adaptive gain control of Vestibuloocular reflex by the cerebellum. J Neurophysiol 39: 954–969
Wolfe JW, Kos CM (1977) Nystagmic responses of the rhesus monkey to rotational stimulation following unilateral labyrinthectomy: final report. Trans Am Acad Ophthalmol Otolaryngol 84: 38–45
Supported by grants nos. 3.228.82 and 3.403.83 from the Swiss National Science Foundation and Dr. Erik Slack-Gyr Foundation
Prof. Precht died on March 12, 1985
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Maioli, C., Precht, W. On the role of vestibulo-ocular reflex plasticity in recovery after unilateral peripheral vestibular lesions. Exp Brain Res 59, 267–272 (1985). https://doi.org/10.1007/BF00230906
- Vestibuloocular reflex