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A morphological study of nerve biopsies from cases of multibacillary leprosy given multidrug therapy

Summary

Nerve biopsies were examined from 17 cases of lepromatous leprosy given WHO-recommended multidrug therapy (MDT) for 2 years. The pathological changes were assessed qualitatively and quantitatively to judge the effectiveness of MTD> The nerves varied very considerably in the severity of their lesions. Some regenerating fibres were seen in most of the nerves. In a few cases, the nerves were almost entirely populated by regenerated fibres, confirming that MTD was effective in halting the disease process within the nerve. Mycobacterium leprae showed morphological features of degenerate bacilli. Some pathological features of the lepromatous lesion are described.

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References

  1. 1.

    Boddingius J (1976) Ultrastructural changes in blood vessels of peripheral nerves in leprosy neuropathy. Acta Neuropathol (Berl) 35:159–181

  2. 2.

    Dastur DK (1978) Leprosy (an infectious and immunological disorder of the nervous system) Handb Clin Neurol 33:421–468

  3. 3.

    Jacobs JM, Love S (1985) Qualitative and quantitative morphology of human sural nerve at different ages. Brain 108:897–924

  4. 4.

    Jacobs JM, Le Quesne PM (1992) Toxic disorders, In: Hume Adams J, Duchen LW (eds) Greenfield's Neuropathology, 5th edn. Edward Arnod, London, pp 881–987

  5. 5.

    Jacobs JM, Shetty VP, Antia NH (1987) Teased fibre studies in leprous neuropathy. J Neurol Sci 79:301–313

  6. 6.

    Lucas SB (1988) Histopathology of leprosy and tuberculosis: an overview. Br Med Bull 44:584–599

  7. 7.

    Mantovani A, Bussolino F, Dejana E (1992) Cytokine regulation of endothelial cell function. FASEB J 6:2591–2599

  8. 8.

    Mshana RN, Belehu A, Stoner GL, Haregewoin A, Harboe M (1982) Demonstration of mycobacterial antigens in leprosy tissues. Int J Lepr 50:1–10

  9. 9.

    Nilsen R, Mengistu G, Reddy BB (1989) The role of nerve biopsies in the diagnosis and management of leprosy. Lepr Rev 60:28–32

  10. 10.

    Ochoa J (1980) Nerve fibre pathology in acute and chronic compression. In: Omer JE, Spinner M (eds) Management of peripheral nerve problems. WB Saunders Co., Philadelphia, pp 487–501

  11. 11.

    Ochoa J, Marotte L (1973) The nature of the nerve lesion caused by chronic entrapment in the guinea pig. J Neurol Sci 19:491–495

  12. 12.

    Raine CS, Wisniewski H, Prineas J (1969) An ultrastructural study of experimental encephalomyelitis in the peripheral nervous system. Lab Invest 21:316–327

  13. 13.

    Rees RJW, Waters MFR, Weddell AGM, Palmer E (1967) Experimental lepromatous leprosy. Nature 215:599–602

  14. 14.

    Ridley DS and Jopling W (1966) Classification of leprosy according to immunity. A five group system. Int J Lepr 34:255–273

  15. 15.

    Sansarricq H (1989) Technical problems related to multidrug therapy in leprosy control. Acta Leprol (Geneve) 7:59–62

  16. 16.

    Schröder J (1986) Proliferation of epineurial capillaries and smooth muscle cells in angiopathic peripheral neuropathy. Acta Neuropathol (Berl) 72:29–37

  17. 17.

    Shetty VP, Antia NH, Jacobs JM (1988) The pathology of early leprous neuropathy. J Neurol Sci 88:115–131

  18. 18.

    Shetty VP, Suchitra K, Uplekar MW, Antia NH (1992) Persistence of M. leprae in the peripheral nerve as compared to skin of multidrug-treated leprosy patients. Lepr Rev (in press)

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Jacobs, J.M., Shetty, V.P. & Antia, N.H. A morphological study of nerve biopsies from cases of multibacillary leprosy given multidrug therapy. Acta Neuropathol 85, 533–541 (1993). https://doi.org/10.1007/BF00230494

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Key words

  • Leprosy
  • Neuropathy
  • Nerve regeneration
  • Demyelination
  • Schwann cells