Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Intralobular growth of myoepithelial cell carcinoma of the breast

  • 56 Accesses

  • 13 Citations

Abstract

Two cases of intralobular carcinoma of the breast showing myoepithelial cell differentiation are reported. One was an in situ lesion localized within a fibroadenoma; the second was predominantly in situ, but areas of invasion were present. The neoplastic cells had round to ovoid nuclei and were polygonal to spindle in shape displaying glycogen rich clear cytoplasm. Alphasmooth muscle actin was present in the cytoplasm of the neoplastic cells in both cases. In one case the same cells displayed cytoplasmic microfilaments at electron microscopic level. Intralobular growth of neoplastic myoepithelial cells has never been described in the literature, and this line of differentiation has to be added to the endocrine and apocrine features occasionally observed in in situ lobular carcinomas of the breast.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Ahmed A (1974) The myoepithelium in human breast fibroadenoma. J Pathol 114:135–138

  2. 2.

    Azzopardi JG, Bennington JL (eds) (1979) Problems in breast pathology. (Major problems in pathology series) W. B. Saunders, London

  3. 3.

    Bocker W, Bier B, Freytag G, Brommelkamp B, Jarasch E-D, Edel G, Dockhorn-Dworniczak B, Schmid KW (1992) An immunohistochemical study of the breast using antibodies to basal and luminal keratins, alpha-smooth muscle actin, vimentin, collagen IV and laminin. Part II: epitheliosis and ductal carcinoma in situ. Virchows Arch [A] 421:323–330

  4. 4.

    Bussolati G (1980) Actin-rich (myoepithelial) cells in lobular carcinoma in situ of the breast. Virchows Arch [A] 32:165–176

  5. 5.

    Bussolati G, Botto Micca F, Eusebi V, Betts CM (1981) Myoepithelial cells in lobular carcinoma in situ of the breast: a parallel immunocytochemical and ultrastructural study. Ultrastruct Pathol 2:219–230

  6. 6.

    Cartagena N, Cabello-Inchausti B, Willis I, Poppiti R (1988) Clear cell myoepithelial neoplasm of the breast. Hum Pathol 19:1239–1243

  7. 7.

    Dardick I, Ostrynski VL, Ekem JK, Leung R, Burford-Mason AP (1992) Immunohistochemical and ultrastructural correlates of muscle-actin expression in pleomorphic adenomas and myoepitheliomas based on comparison of formalin and methanol fixation. Virchows Arch [A] 421:95–104

  8. 8.

    Enghardt MH, Hale JH (1989) An epithelial and spindle cell breast tumour of myoepithelial origin. An immunohistochemical and ultrastructural study. Virchows Arch [A] 416:177–184

  9. 9.

    Erlandson RA, Rosen PP (1982) Infiltrating myoepithelioma of the breast. Am J Surg Pathol 6:785–793

  10. 10.

    Eusebi V, Azzopardi JG (1980) Lobular endocrine neoplasia in fibroadenoma of the breast. Histopathology 4:413–428

  11. 11.

    Eusebi V, Betts C, Haagensen DE, Gugliotta P, Bussolati G, Azzopardi JG (1984) Apocrine differentiation in lobular carcinoma of the breast: a morphologic, immunologic, and ultrastructural study. Hum Pathol 15:134–140

  12. 12.

    Eusebi V, Casadei GP, Bussolati G, Azzopardi JG (1987) Adenomyoepithelioma of the breast with a distinctive type of apocrine adenosis. Histopathology 11:305–315

  13. 13.

    Eusebi V, Collina G, Bussolati G (1989) Carcinoma in situ in sclerosing adenosis of the breast: a immunocytochemical study. Semin Diagn Pathol 6(2):146–152

  14. 14.

    Eusebi V, Magalhaes F, Azzopardi JG (1992) Pleomorphic lobular carcinoma of the breast: an aggressive tumor showing apocrine differentiation. Hum Pathol 23:655–662

  15. 15.

    Flotte TJ, Bell DA, Greco MA (1980) Tubular carcinoma and sclerosing adenosis. The use of basal lamina as differential feature. Am J Surg Pathol 4:75–77

  16. 16.

    Gugliotta P Sapino A, Macrì L, et al. (1988) Specific demonstration of myoepithelial cells by anti-alpha smooth muscle actin antibody. J Histochem Cytochem 36:659–663

  17. 17.

    Hamperl H (1970) The myothelia (myoepithelial cells): normal state, regressive changes, hyperplasia, tumors. Curr Top Pathol 53:194–194

  18. 18.

    Hsu SM, Raine L, Fanger H (1981) The use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase technique: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29:577–580

  19. 19.

    Mazoujian G, Pinkus G, Davis S, et al. (1982) Immunoperoxidase localization of a breast gross cystic disease fluid protein (abstract). Lab Invest 46:52–53

  20. 20.

    Rosen PP (1987) Adenomyoepithelioma of the breast. Hum Pathol 18:1232–1237

  21. 21.

    Schurch W, Potvin C, Seemayer TA (1985) Malignant myoepithelioma (myoepithelial carcinoma) of the breast: an ultrastructural and immunocytochemical study. Ultrastruct Pathol 8:1–11

  22. 22.

    Tamai M (1992) Intraductal growth of malignant mammary myoepithelioma. Am J Surg Pathol 16(11):1116–1125

  23. 23.

    Tavassoli FA (1991) Myoepithelial lesions of the breast. Myoepitheliosis, adenomyoepithelioma, and myoepithelial carcinoma. Am J Surg Pathol 15(6):554–568

  24. 24.

    Thorner PS, Kahn JH, Baumal R, Lee K, Moffatt W (1986) Malignant myoepithelioma of the breast. An immunohistochemical study by light and electron microscopy. Cancer 57:745–750

Download references

Author information

Correspondence to V. Eusebi.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Soares, J., Tomasic, G., Eusebi, V. et al. Intralobular growth of myoepithelial cell carcinoma of the breast. Vichows Archiv A Pathol Anat 425, 205–210 (1994). https://doi.org/10.1007/BF00230358

Download citation

Key words

  • Breast
  • Lobular carcinoma in situ
  • Myoepithelial cells