In adult immobilised, decerebrate rats, administration of l-3,4-dihydroxyphenylalanine, stimulation of the mesencephalic locomotor centre, or a combination of the two elicited fictive locomotor patterns in hindlimb muscle nerves. The patterns correspond closely to those observed in decerebrate animals that were free to move.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Atsuta Y, Garcia-Rill E, Skinner RD (1990) Characteristics of electrically induced locomotion in rat in vitro brain stem-spinal cord preparation. J Neurophysiol 64:727–735
Baev KV (1977) Rhythmic discharges in hindlimb motor nerves of the decerebrate, immobilized cat induced by intravenous injection of DOPA. Neurophysiology 9:165–167
Barbeau H, Chau C, Rossignol S (1993) Noradrenergic agonists and locomotor training affect locomotor recovery after cord transection in adult cats. Brain Res Bull 30:387–393
Bem T, Orsal D, Cabelguen JM (1993) Fictive locomotion in the adult thalamic rat. Exp Brain Res 97:301–304
Cazalets JR, Grillner S, Menard I, Cremieux J, Clarac F (1990) Variability as a characteristic of immature motor systems: an electromyographic study of swimming in the newborn rat. Behav Brain Res 40:215–225
Cazalets JR, Sqalli-Houssaini Y, Clarac F (1992) Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in neonatal rat. J Physiol (Lond) 455:187–204
Coles SK, Iles JF, Nicolopoulos-Stournaras S (1989) The mesencephalic centre controlling locomotion in the rat. Neuroscience 28:149–157
Cowley KC, Schmidt BJ (1994) A comparison of motor patterns induced by N-methyl-d-aspartate, acetylcholine and serotonin in the in vitro neonatal rat spinal cord. Neurosci Lett 171:147–150
Fleshman JW, Lev-Tov A, Burke RE (1984) Peripheral and central control of flexor digitorum longus and flexor hallucis longus motoneurons: the synaptic basis for functional diversity. Exp Brain Res 54:133–149
Goudard I, Orsal D, Cabelguen JM (1992) An electromyographic study of the hindlimb locomotor movements in the acute thalamic rat. Eur J Neurosci 4:1130–1139
Grillner S (1981) Control of locomotion in bipeds, tetrapods, and fish. In: Brookhart JM, Mountcastle VB (eds) Motor control. (Handbook of physiology, sect 1, The nervous system, vol II) American Physiological Society, Bethesda, pp 1179–1236
Gruner JA, Altman J, Spivak N (1980) Effects of arrested cerebellar development on locomotion in the rat. Exp Brain Res 40:361–373
Iles JF, Coles SK (1991) Effects of loading on muscle activity during locomotion in the rat. In: Armstrong DM, Bush BMH (eds) Locomotor neural mechanisms in arthropods and vertebrates. Manchester University Press, Manchester, pp 196–201
Leon R de, Hodgson JA, Roy RR, Edgerton VR (1994) Extensor-and flexor-like modulation within motor pools of the rat hind-limb during treadmill locomotion and swimming. Brain Res 654:241–250
Magnuson DSK, Schramm MJ, MacLean JN (1995) Long-duration, frequency dependent motor responses evoked by ventrolateral funiculus stimulation in the neonatal rat spinal cord. Neurosci Lett 192:97–100
Nicolopoulos-Stournaras S, Iles JF (1984) Hindlimb muscle activity during locomotion in the rat (Rattus norvegicus) (Rodentia:Muridae). J Zool (Lond) 203:427–440
Pearson KG, Rossignol S (1991) Fictive motor pattern in chronic spinal cats. J Neurophysiol 66:1874–1887
Perreault M-C, Angel MJ, Guertin P, McCrea DA (1995) Effects of stimulation of hindlimb flexor group II afferents during fictive locomotion in the cat. J Physiol (Lond) 487:211–220
Perret C, Cabelguen JM (1980) Main characteristics of the hindlimb locomotor cycle in the decorticate cat with special reference to bifunctional muscles. Brain Res 187:333–352
Rossignol S, Dubuc R (1994) Spinal pattern generation. Curr Opin Neurobiol 4:894–900
Smith JL, Chung SH, Zernicke RF (1993) Gait-related motor pattern and hindlimb kinetics for the cat trot and gallop. Exp Brain Res 94:308–322
Sqalli-Houssaini Y, Cazalets JR, Clarac F (1993) Oscillatory properties of the central pattern generator for locomotion in neonatal rats. J Neurophysiol 70:803–813
Vanderwolf CH, Kolb B, Cooley RK (1978) Behaviour of the rat after removal of the neocortex and hippocampal formation. J Comp Physiol Psychol 92:156–175
Viala D, Buser P (1971) Modalités d'obtention de rythmes locomoteurs chez le lapin spinal par traitements pharmacologiques (DOPA, 5-HTP, d-amphétamine). Brain Res 35:151–165
Vidal C, Viala D, Buser P (1979) Central locomotor programming in the rabbit. Brain Res 168:57–73
Yakhnitsa IA, Pilyavskii AI, Bulgakova NV (1985) Comparative analysis of the kinematics of hind limb movements in rats during different kinds of locomotion. Neurophysiology 17:127–135
About this article
Cite this article
Iles, J.F., Nicolopoulos-Stournaras, S. Fictive locomotion in the adult decerebrate rat. Exp Brain Res 109, 393–398 (1996). https://doi.org/10.1007/BF00229623
- Fictive locomotion
- Mesencephalic locomotor region