Experimental Brain Research

, Volume 80, Issue 1, pp 189–195 | Cite as

Pre- and post-training lesions of the intermediate medial hyperstriatum ventrale and passive avoidance learning in the chick

  • T. A. Patterson
  • D. B. Gilbert
  • S. P. R. Rose


Three distinct nuclei of the chick forebrain — the intermediate medial hyperstriatum ventrale (IMHV), lobus parolfactorius (LPO), and paleostriatum augmentatum (PA) — show metabolic, morphological, and neurophysiological changes following training on a passive avoidance task, suggesting that these and other areas of the chick forebrain participate in memory formation for this task. Considerable evidence exists for lateralization of memory processes in the chick. Several experiments examined the effects of lesions in the IMHV on the ability of chicks to learn and retain the avoidance task. Pre-training bilateral lesions in the IMHV produced an impairment in avoidance responding tested three hours after training. Pre-training unilateral lesions in the left but not the right IMHV resulted in a similar impairment. However, bilateral IMHV ablations, given either 1 or 6 h post-training, did not impair retention. IMHV lesions did not impair retention of a simple escape learning task. These results are consistent with other studies that have examined the effects of bilateral IMHV lesions on acquisition of passive avoidance and extend these findings by demonstrating lateralization of acquisition involving the left IMHV. The results also suggest that, as early as one hour post-training, the IMHV is not necessary to retain the memory and indicate that other forebrain structures, possibly the LPO or PA, may maintain the memory trace following training. Hypotheses to account for these results and indications of future research are discussed.

Key words

Lesions Learning Memory Lateralization Chick 


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  1. Ali SM, Bullock S, Rose SPR (1988) Phosphorylation of synaptic proteins in chick forebrain: changes with development and passive avoidance training. J Neurochem 50:1579–1587Google Scholar
  2. Benowitz L (1972) Effects of forebrain ablations on avoidance learning in chicks. Physiol Behav 9:601–688Google Scholar
  3. Bradley PM, Galal KM (1987) The effects of protein synthesis inhibition on structural changes associated with learning in the chick. Dev Brain Res 37:267–276Google Scholar
  4. [Bradley P, Horn G, Bateson P (1981) Imprinting: an electron microscopic study of chick hyperstriatum ventrale. Exp Brain Res 41:115–120Google Scholar
  5. Burgoyne R, Rose SPR (1980) Subcellular localisation of increased incorporation of [3H]-fucose following passive avoidance learning in the chick. Neurosci Lett 19:343–348Google Scholar
  6. Cherkin A, Lee-Teng E (1965) Interruption by halothane of memory consolidation in chicks. Fed Proceed 24:328Google Scholar
  7. Cippolla-Neto J, Horn G, McCabe BJ (1982) Hemispheric asymmetry and imprinting: the effect of sequential lesions to the hyperstriatal ventrale. Exp Brain Res 48:22–27Google Scholar
  8. Davies DC, Taylor DA, Johnson MH (1988) The effects of hyperstriatal lesions on one-trial passive avoidance learning in the chick. J Neurosci 8:4662–4666Google Scholar
  9. Gibbs ME, Ng KT (1977) Psychobiology of memory: towards a model of memory formation. Biobehav Rev 1:113–136Google Scholar
  10. Gilbert DB, Patterson TA, Rose SPR (1989) Midazolam induces amnesia in a simple, one-trial, maze-learning task in young chicks. Pharmacol Biochem Behav (in press)Google Scholar
  11. Horn G (1985) Memory, imprinting and the brain. Clarendon Press, OxfordGoogle Scholar
  12. Horn G, Rose SPR, Bateson PPG (1973) Experience and plasticity in the nervous system. Science 181:506–514Google Scholar
  13. Horn G, McCabe BJ, Cipolla-Neto J (1983) Imprinting in the domestic chick: the role of each side of the hyperstriatum ventrale in acquisition and retention. Exp Brain Res 53:91–98Google Scholar
  14. Johnson MH, Horn G (1986) Dissociation of recognition memory and associative learning by a restricted lesion of the chick forebrain. Neuropsychologica 24:329–340Google Scholar
  15. Kossut M, Rose SPR (1984) Differential 2-deoxyglucose uptake into chick brain structures during passive avoidance learning. Neuroscience 12:971–977Google Scholar
  16. Lossner B, Rose SPR (1983) Passive avoidance training increases fucokinase activity in right forebrain tissue of day-old chicks. J Neurochem 41:1357–1363Google Scholar
  17. McCabe NR, Rose SPR (1987) Increased fucosylation of chick proteins following training: effects of cycloheximide. J Neurochem 48:538–542Google Scholar
  18. McCabe BJ, Cipolla-Neto J, Horn G, Bateson P (1982) Amnesic effects of bilateral lesions placed in the hyperstriatum ventrale of the chick after imprinting. Exp Brain Res 48:13–21Google Scholar
  19. McCabe BJ, Horn G, Bateson PPG (1981) Effects of restricted lesions of the chick forebrain on the acquisition of filial preferences during imprinting. Brain Res 205:29–37Google Scholar
  20. Mason RJ, Rose SPR (1987) Lasting changes in spontaneous multiunit activity in the chick brain following avoidance training. Neuroscience 21:931–941Google Scholar
  21. Mason RJ, Rose SPR (1988) Passive avoidance learning produces focal elevation of bursting activity in the chick brain: amnesia abolishes the increase. Behav Neural Biol 49:280–292Google Scholar
  22. Mileusnic R, Rose SPR, Tillson P (1980) Passive avoidance learning results in region-specific changes in concentration of and incorporation into colchicine binding proteins in the chick forebrain. J Neurochem 34:1007–1015Google Scholar
  23. Morgan L (1896) Habit and instinct. Edward Arnold, LondonGoogle Scholar
  24. Patel SN, Stewart MG (1988) Changes in the number and structure of dendritic spines 25 h after passive avoidance training in the domestic chick, Gallus domesticus. Brain Res 449:34–46Google Scholar
  25. Patel SN, Rose SPR, Stewart MG (1988) Training induced dendritic spine density changes are specifically related to memory formation processes in the chick, Gallus domesticus. Brain Res 463:168–173Google Scholar
  26. Patterson TA, Alvarado MC, Warner IT, Bennett EL, Rosenzweig MR (1986) Memory stages and brain asymmetry in chick learning. Behav Neurosci 100:856–865Google Scholar
  27. Rose SPR (1985) Passive avoidance training in the chick: a model for the analysis of the cell biology of memory storage. In: Alkon DL, Woody CD (eds) Neural mechanisms of conditioning. Plenum Press, New York, pp 223–247Google Scholar
  28. Rose SPR, Csillag A (1985) Passive avoidance training results in lasting changes in deoxyglucose metabolism in left hemisphere regions of chick brain. Behav Neural Biol 44:315–324Google Scholar
  29. Rose SPR, Gibbs ME, Hambley J (1980) Transient increase in forebrain muscarinic cholinergic receptors following passive avoidance learning. Neuroscience 5:169–172Google Scholar
  30. Schliebs R, Rose SPR, Stewart MG (1985) Effects of passive avoidance learning on in vitro protein synthesis in forebrain slices of day old chicks. J Neurochem 44:1014–1028Google Scholar
  31. Serrano PA, Ramus SJ, Bennett EL, Rosenzweig MR (1988) A comparative study of the LPO and MHV in memory formation in the chick brain. Soc Neurosci Abstr 14:250Google Scholar
  32. Stewart MG, Csillag A, Rose SPR (1987) Alterations in synaptic structure in the paleostriatal complex of the domestic chick, Gallus domesticus, following passive avoidance training. Brain Res 416:69–81Google Scholar
  33. Stewart MG, Rose SPR, King TS, Gabbott PLA, Bourne R (1984) Hemispheric asymmetry of synapses in chick medial hyperstriatum ventrale following passive avoidance training: a stereological investigation. Dev Brain Res 12:261Google Scholar
  34. Sukumar R, Rose SPR, Burgoyne RD (1980) Increased incorporation of [3H]-fucose into chick brain glycoprotein following training on a passive avoidance task. J Neurochem 34:1000–10007Google Scholar
  35. Youngren OM, Phillips RE (1978) A stereotaxic atlas of the 3 day old chick. J Comp Neurol 181:567–600Google Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • T. A. Patterson
    • 1
  • D. B. Gilbert
    • 1
  • S. P. R. Rose
    • 1
  1. 1.Brain and Behaviour Research Group, Department of BiologyOpen UniversityMilton KeynesUK

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