Molecular and Cellular Biochemistry

, Volume 89, Issue 1, pp 69–72 | Cite as

Insulin sensitivity in experimental cirrhosis

  • Soheli A. Chowdhury
  • Roy Taylor
Original Article


To investigate insulin action in muscle and adipose tissue in hepatic cirrhosis, a recently described animal model was used. Dimethylnitrosamine administration induced histologically proven cirrhosis. Contrary to expectation, muscle strips from cirrhotic rats displayed increased insulin sensitivity both with respect to glycogen synthesis (ED50 0.11 ± 0.01 vs 0.23 ± 0.04 nmol/1; p < 0.03) and glucose oxidation (ED50 0.36 ±0.07 vs 0.97 ± 12 nmol/1; p < 0.02). As the cirrhotic rats had failed to gain weight normally, it is postulated that a state of relative starvation accounted for the enhanced insulin sensitivity. These data demonstrate that the severe insulin resistance characteristically associated with cirrhosis is reversible. Control of nutritional state in future studies upon DMNA induced cirrhosis should permit detailed examination of the cellular mechanisms controlling insulin sensitivity in hepatic cirrhosis.

Key words

cirrhosis insulin sensitivity muscle in vitro 


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Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • Soheli A. Chowdhury
    • 1
  • Roy Taylor
    • 1
  1. 1.Department of MedicineUniversity of Newcastle upon TyneUK

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