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Dynamics of vascular remodeling: An overview and bibliography

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References/Bibliography

  1. 1.

    The Multicenter European Research Trial with Cilazapril after Angioplasty to Prevent Transluminal Coronary Obstruction and Restenosis (MERCTOR) Study Group. Results of the MERCATOR study: A multicenter, randomized, double-blind placebo-controlled trial. Circulation 1992;86:100–110.

  2. 2.

    Abell TJ, Richards AM, Ikram H, Espiner EA, Yandle T. Atrial natriuretic factor inhibits proliferation of vascular smooth muscle cells stimulated by platelet-derived growth factor. Biochem Biophys Res Commun 1989;160:1392–1396.

  3. 3.

    Adams PC, Badimon JJ, Badimon L, Chesebro JH, Fuster V. Role of platelets in atherogenesis: Relevance to coronary arterial restenosis after angioplasty. Cardiovas Clin 1987;18:49–71.

  4. 4.

    Adams PC, Lam JY, Badimon L, Chesebro JH, Fuster V. Interactions of platelets and vessel wall in the development of restenosis after coronary angioplasty. Ann NY Acad Sci 1987;516:605–620.

  5. 5.

    Alden SM, Pierce RA, Tozzi CA, Mackenzie JW, Deak SB, Boyd CD. Changes in aortic levels of tropoelastin mRNA following treatment of rats with the antihypertensive drugs captopril and hydralazine. J Surg Res 1991;51:491–494.

  6. 6.

    Allen K, Hwaorth SG. Human postnatal pulmonary arterial remodeling. Lab Invest 1988;59:702–709.

  7. 7.

    Amento EP, Ehsani N, Palmer H, Libby P. Cytokines and growth factors positively and negatively regulate interstitial collagen gene expression in human vascular smooth muscle cells. Arterioscler Thromb 1991;11:1223–1230.

  8. 8.

    Anderson PG, Bishop SP, Digerness SB. Vascular remodeling and improvement of coronary reserve after hydralazine treatment in spontaneously hypertensive rats. Cir Res 1989;64:1127–1136.

  9. 9.

    Ando J, Nomura H, Kamiya A. The effect of fluid shear stress on the migration and proliferation of cultured endothelial cells. Microvasc Res 1987;33:62–70.

  10. 10.

    Anonymous. Pharmacology of cardiac and vascular remodeling. A satellite symposium of the 11th World Congress of the International Union of Pharmacology (IUPHAR). Basic Res Cardiol 1991;86(Suppl 1):1–187.

  11. 11.

    Anonymous. Vascular remodeling: Proceedings of a Satellite Symposium of the 2nd International Symposium on Endothelium-Derived Vasoactive Factors. J Cardiovasc Pharmacol 1993;21(Suppl 1):S1–S5.

  12. 12.

    Armstrong ML, Heistad DD, Marcus ML, Megan MB, Piegors DJ. Structural and hemodynamic responses of peripheral arteries of macaque monkeys to atherogenic diet. Arteriosclerosis 1985;5:336–346.

  13. 13.

    Arntt EN, Isner JM, Redwood DR. Coronary artery narrowing in coronary heart disease: Comparison of cineangiographic and necropsy findings. Ann Intern Med 1979;91:350–356.

  14. 14.

    Arora RR, Konrad K, Badhwar K, Hollman J. Restenosis after transluminal coronary angioplasty: A risk factor analysis. Cathet Cardiovasc Diagn 1990;19:17–22.

  15. 15.

    Assoian RK, Grotendorst GR, Miller DM, Sporn MB. Cellular transformation by coordinate action of three peptide growth factors from human platelets. Nature 1984;309:804–806.

  16. 16.

    Assoian RK, Sporn MB. Type beta transforming growth factor in human platelets: release during platelet degranulation and action on vascular smooth muscle cells. J Cell Biol 1986;102:1217–1223.

  17. 17.

    Atkinson JE, Olson JW, Altiere RJ, Gillespie MN. Evidence that hypoxic pulmonary vascular remodeling in rats is polyamine dependent. J Appl Physiol 1987;62:1562–1568.

  18. 18.

    Austin GE, Ratliff NB, Hollman J, Tabei S, Phillips DF. Intimal proliferation of smooth muscle as an explanation for recurrent coronary artery stenosis after percutaneous transluminal coronary angioplasty. J Am Coll Cardiol 1985;6:369–375.

  19. 19.

    Badesch DB, Lee PD, Parks WC, Stenmark KR. Insulin-like growth factor I stimulates elastin synthesis by bovine pulmonary arterial smooth muscle cells. Biochem Biophys Res Commun 1989;160:382–387.

  20. 20.

    Baim DS, Kuntz RE. Directional coronary atherectomy: How much lumen enlargement is optimal? Am J Cardiol 1993;72:65E-70E.

  21. 21.

    Baird A, Durkin T. Inhibition of endothelial cell proliferation by type B-transforming growth factors: Interactions with acidic and basic fibroblast growth factors. Biochem Biophys 1986;138:476–482.

  22. 22.

    Barger AC, Beeuwkes R, Lainey LL, Silverman KJ. Hypothesis; vasa vasorum and neovascularization of human coronary arteries. N Engl J Med 1984;310:175–177.

  23. 23.

    Bassiouny HD, Lieber BB, Giddens DP, Xu CP, Glagov S. Differential effect of wall shear stress on intimal thickness in critical and subcritical stenosis (abstrt). Circulation 1988;78(Suppl II):II394.

  24. 24.

    Bassiouny HS, Lieber BB, Xu CP, Giddens DP, Glagov S, Zarins CK. Quantitative inverse correlation of wall shear stress with experimental intimal thickening. Surg Forum 1988;39:328–330.

  25. 25.

    Battistini B, Chailler P, D'Orleans-Juste P, Briere N, Sirois P. Growth regulatory properties of endothelins. Peptides 1993;14:385–399.

  26. 26.

    Baumbach GL, Heistad GL. Remodeling of cerebral aterioles in chronic hypertension. Hypertension 1989;13:968–972.

  27. 27.

    Baumback GL, Ghoneim S. Vascular remodeling in hypertension. Scanning Microsc 1993;7:137–142.

  28. 28.

    Bauriedel G, Windstetter U, KeMaio SJ, Kandolf R, Hofling B. Migratory activity of human smooth muscle cells cultivated from coronary and peripheral primary and restenotic lesions removed by percutaneous atherectomy. Circulation 1992;85:554–564.

  29. 29.

    Beatt KJ, Luijten HE, deFeyter PJ, van den Brand M, Reiber JHC, Serruys PW. Change in diameter of coronary segments adjacent to stenoses after percutaneous transluminal coronary angioplasty: Failure of percent diameter stenosis measurement to reflect morphologic changes induced by balloon dilation. J Am Coll Cardiol 1988;12:35–323.

  30. 30.

    Beatt KJ, Serruys PW, Luijten HE, Rensing BJ, Suryapranata H, de Feyter P. Restenosis after coronary angioplasty: The paradox of increased lumen diameter and restenosis. J Am Coll Cardiol 1992;19:258–266.

  31. 31.

    Bell L, Madri JA. Influence of the angiotensin system on endothelial and smooth muscle cell migration. Am J Pathol 1990;137:7–12.

  32. 32.

    Berk B, Vekshtein V, Gordon H. Angiotensin II-stimulated converting enzyme inhibition reduces restenosis in experimental angioplasty. Hypertension 1989;13:305–314.

  33. 33.

    Berk BC, Gordon JB, Alexander RW. Pharmacologic roles of heparin and glucocorticoids to prevent restenosis after coronary angioplasty. J Am Coll Cardiol 1991;17(Suppl B):111B-117B.

  34. 34.

    Berk BC, Vekshtein V, Gordon HM, Tsuda T. Angiotensin II-stimulated protein protein synthesis in cultured vascular smooth muscle cells. Hypertension 1989;13:305–314.

  35. 35.

    Bertrand ME, Lablanche JM, Fourrier JL, Gommeaux A, Ruel M. Relation to restenosis after percutaneous transluminal coronary angioplasty of vasomotion of the dilated coronary arterial segment. Am J Cardiol 1989;63:277–281.

  36. 36.

    Bier JD, Kakuta T, Currier JW, et al. Arterial remodeling: Importance in primary versus restenotic lesions (abstr). J Am Coll Cardiol 1994;23:139A.

  37. 37.

    Bilazarian S, Currier J, Haudenschild C. Angiotensin converting enzyme inhibition reduces restenosis in experimental angioplasty (abstr). J Am Coll Cardiol 1991;7(Suppl A):268A.

  38. 38.

    Biro S, Yu ZX, Casscells W. Fibroblast and transforming growth factors in endothelial wound healing in vitro (abstr). J Am Coll Cardiol 1991;17:24A.

  39. 39.

    Bjorkerud S. Effects of transforming growth factor-beta 1 on human arterial cells in vitro. Arterioscl Thromb 1991;11:892–902.

  40. 40.

    Bjorkerud S, Bondjiers G. Arterial repair and atherosclerosis after mechanical injury: Part 5. Tissue response after induction of a large superficial transverse injury. Atherosclerosis 1973;18:235–255.

  41. 41.

    Black AJR, Anderson HV, Roubin GS, Powelson SW, Douglas JS, King SB. Repeat coronary angioplasty: Correlates of a second restenosis. J Am Coll Cardiol 1988;11:714–718.

  42. 42.

    Block PC. Restenosis after percutaneous transluminal coronary angioplasty—anatomic and pathophysiological mechanisms. Circulation 1990;81(Suppl IV):IV2-IV4.

  43. 43.

    Block PC, Myler RK, Stertzer S, Fallon JT. Morphology after transluminal angioplasty in human beings. N Engl J Med 1981;305:382–385.

  44. 44.

    Bond MG, Adams MR, Bullock BC. Complicating factors in evaluating coronary artery atherosclerosis. Artery 1981;9:21–29.

  45. 45.

    Botney MD, Bahadori L, Gold LI. Vascular remodeling in primary pulmonary hypertension. Potential role for transforming growth factor-beta. Am J Pathol 1994;144:286–295.

  46. 46.

    Botney MD, Parks WC, Crouch EC, Stenmark K, Mecham RP. Transforming growth factor-β1 is decreased in remodeling hypertensive bovine pulmonary arteries. J Clin Invest 1992;89:1629–1635.

  47. 47.

    Boyd CD, Kniep AC, Pierce RA, et al. Increased elastin mRNA level associated with surgically induced intimal injury. Connect Tissue Res 1988;18:65–78.

  48. 48.

    Brott BC, Labinaz M, Culp SC, et al. Vessel remodeling after angioplasty: Comparative anatomic studies (abstr). Circulation 1994;23:138A.

  49. 49.

    Brown BG, Bolson EL, Dodge HT. Dynamic mechanisms in human coronary stenosis. Circulation 1984;70:917–922.

  50. 50.

    Bruneval P, Guermoprez JL, Perrier P, Carpentier A, Camilleri JP. Coronary artery restenosis following transluminal coronary angioplasty. Arch Pathol Lab Med 1986;110:1186–1187.

  51. 51.

    Buckley BH, Hutchins GM. Accelerated “atherosclerosis”: A morphologic study of 87 saphenous vein coronary artery bypass grafts. Circulation 1977;55:163–169.

  52. 52.

    Cai JP, Falanga V, Chin YH. Transforming growth factorbeta regulates the adhesive interaction between mononuclear cells and microvascular endothelium. J Invest Dermatol 1991;97:169–174.

  53. 53.

    Califf RM, Fortin DF, Frid DJ. Restenosis after coronary angioplasty: An overview. J Am Coll Cardiol 1991;17(Suppl B):2B-13B.

  54. 54.

    Campbell GR, Campbell JH. Phenotypic modulation of smooth muscle cells in primary culture. Vasc Smooth Muscle Cult 1987;00:39–55.

  55. 55.

    Campbell GR, Campbell JH, Manderson JA, Horrigan S, Rennick RE: Arterial smooth muscle. Arch Pathol Lab Med 1988;112:977–986.

  56. 56.

    Campbell JH, Campbell GR. Chemical stimuli of the hypertrophic response to smooth muscle. In: Seidel CL, ed. Hypertrophic Response of Smooth Muscle 1987:153–192.

  57. 57.

    Campbell-Boswell M, Robertson AL. Effects of angiotensin II and vasopressin on human smooth muscle cells in vitro. Exp Mol Pathol 1981;35:265–276.

  58. 58.

    Caro CG, Fitz-Gerald JM, Schroter RC. Atheroma and arterial wall shear: Observation, correlation and proposal of a shear-dependent mass transfer mechanism for atherogenesis. Proc R Soc Lond (Biol) 1971;117:109–159.

  59. 59.

    Casscells W. Migration of smooth muscle and endothelial cells. Critical events in restenosis. Circulation 1992;86:723–729.

  60. 60.

    Casscells W, Engler D, Wilerson JT. Mechanisms of restenosis. Tex Heart Inst J 1994;21:68–77.

  61. 61.

    Castellot JJ, Karnovsky MJ. Heparin and the regulation of growth in the vascular wall. Vasc Smooth Muscle Cult 1987;00:93–115.

  62. 62.

    Chabrier PE, Esanu A, Braquet P. Vascular remodeling and antihypertensive therapy: The example of cicletanine. J Cardiovasc Pharmacol 1993;21(Suppl 1):S50-S53.

  63. 63.

    Chen JK, Hoshi H, McKeehan WL. Transforming growth factor B specifically stimulated synthesis of proteoglycans in human adult arterial smooth muscle cells. Proc Natl Acad Sci USA 1987;84:5287–5291.

  64. 64.

    Chesebro JH, Fuster V. Platelet-inhibitor drugs before and after coronary artery bypass surgery and coronary angioplasty: The basis of their use, data from animal studies, clinical trial data, and current recommendations. Cardiology 1986;73:292–305.

  65. 65.

    Chesebro JH, Lam JYT, Badimon L, Fuster V. Restenosis after arterial angioplasty: A hemorrheologic response to injury. Am J Cardiol 1987;60:10B-16B.

  66. 66.

    Clark JM, Glagov S. Transmural organization of the arterial wall: The lamellar unit revisited. Arteriosclerosis 1985;5:19–34.

  67. 67.

    Clowes AW, Clowes HM, Reidy MA. Kinetics of cellular proliferation after arterial injury III. Endothelial and smooth muscle growth in chronically denuded vessels. Lab Invest 1986;54:295–303.

  68. 68.

    Clowes AW, Clowes MM. Kinetics of cellular proliferation after arterial injury II: Inhibition of smooth muscle growth by heparin. Lab Invest 1985;85:611–616.

  69. 69.

    Clowes AW, Reidy MA, Clowes MM. Mechanism of stenosis after arterial injury. Lab Invest 1983;49:208–215.

  70. 70.

    Clowes AW, Reidy MA, Clowes MM. Kinetics of cellular proliferation after arterial injury. Lab Invest 1983;49:327–333.

  71. 71.

    Clowes AW, Schwartz SM. Significance of quiescent smooth muscle migration in the injured rat carotid artery. Circ Res 1995;56:139–145.

  72. 72.

    Clozel M, Breu V, Burri K. Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist. Nature 1993;365:759–761.

  73. 73.

    Cocks TM, Manderson JA, Mosse PRL, Campbell GR, Angus JA. Development of a large fibromuscular intimal thickening does not impair endothelium-dependent relaxation in rabbit carotid artery. Blood Vessels 1987;24:192–200.

  74. 74.

    Cooke JP, Rossitch E, Andon NA, Loscalzo J, Dzau VJ. Flow activates an endothelial potassium channel to release an endogenous nitrovasodilator. J Clin Invest 1991;88:1663–1671.

  75. 75.

    Cooke JP, Singer AH, Tsao P, Zera P, Rowan RA, Billingham ME. Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit. J Clin Invest 1992;90:1168–1172.

  76. 76.

    Cunningham LD, Brecher P, Cohen RA. Platelet-derived growth factor receptors on microvascular endothelial cells mediate relaxation via nitric oxide in rat aorta. J Clin Invest 1992;89:878–882.

  77. 77.

    Currier JW, Faxon DP. Animal models of restenosis: In: Schwartz RS, ed. Coronary Restenosis. London: Blackwell, 1993:293–324.

  78. 78.

    Dartsch PC, Voisard R, Bauriedel G, Hofling B, Betz E. Growth characteristics and cytoskeletal organization of cultured smooth muscle cells from human primary stenosing lesion. Arteriosclerosis 1990;10:62–75.

  79. 79.

    Davies PF. How do vascular endothelial cells respond to flow? News Physiol Sci 1989;4:22–25.

  80. 80.

    Davies PF, Remuzzi A, Gordon EJ, Dewey CF, Gimbrone MA. Turbulent fluid shear stress induces vascular endothelial cell turnover in vitro. Proc Natl Acad Sci USA 1986;83:2114–2117.

  81. 81.

    Davies PF, Tripathi SC. Mechanical stress mechanisms and the cell: An endothelial paradigm. Circ Res 1993;72:239–245.

  82. 82.

    de Morais CF, Lopes EA, Checchi H, Arie S, Pileggi F. Percutaneous transluminal coronary angioplasty: Histopathological analysis of nine necropsy cases (abstr). Virchows Arch 1986;410:195–202.

  83. 83.

    Dehmer GJ, Popura JS, van den Berg EK, et al. Reduction in the rate of early stenosis after coronary angioplasty by a diet supplemented with n-3 fatty acids. N Engl J Med 1988;319:733–740.

  84. 84.

    DeMey JG, Van Der Heijden H, Janssen G, Fazzi G. Structural and functional remodeling of poststenotic arteries in the rat. Adv Exp Med Biol 1993;346:283–290.

  85. 85.

    Dempsey EC, Stenmark KR, McMurtry IF, O'Brien RF, Voelkel NF, Badesch DB. Insulin-like growth factor I and protein kinase C activation stimulate pulmonary artery smooth muscle cell proliferation through separate but synergistic pathways. J Cell Physiol 1990;144:159–165.

  86. 86.

    Deynck R, Jarrett JA, Chen EY, et al. Human transforming growth facor-B complementary DNA sequence and expression in normal and transformed cells. Nature 1985;316:701–705.

  87. 87.

    Dictor M. Vascular remodeling in Kaposi's sarcoma and avian hemangiomatosis: Relation to the vertebrate lymphatic system. Lymphology 1988;21:53–60.

  88. 88.

    Douglas J, King S, Roubin G. Influence of the methodology of percutaneous transluminal coronary angioplasty on restenosis. Am J Cardiol 1987;60:29B-33B.

  89. 89.

    Dull RO, Davies PF. Flow modulation of agonist (ATP) response (Ca++) coupling in vascular endothelial cells. Am J Physiol 1991;261:H149-H151.

  90. 90.

    Dzau VJ, Gibbons GH. Cell biology of vascular hypertrophy in systemic hypertension. Am J Cardiol 1988;62:30G-35.

  91. 91.

    Dzau VJ, Gibbons GH. Endothelium and growth factors on vascular remodeling of hypertension. Hypertension 1991;18(Suppl III):III15-III121.

  92. 92.

    Dzau VJ, Gibbons GH. Vascular remodeling: Mechanisms and implications. J Cardiovasc Pharmacol 1993;21(Suppl 1):S1-S5.

  93. 93.

    Dzau VJ, Gibbons GH, Morishita R, Pratt RE. New perspectives in hypertension research. Potential of vascular biology. Hypertension 1994;23:1132–1140.

  94. 94.

    Ellis SG, Bates ER, Schaible T, Weisman HF, Pitt B, Topol EJ. Prospects for the use of antagonists to the platelet glycoprotein IIb/IIIa receptor post-angioplasty restenosis and thrombosis. J Am Coll Cardiol 1991;17(Suppl B):89B-95B.

  95. 95.

    Ellis SG, Muller DWM. Arterial injury and the enigma of coronary restenosis. J Am Coll Cardiol 1992;19:275–277.

  96. 96.

    Ellis SG, Roubin GS, King SB, Douglas JS, Cox WR. Importance of stenosis morphology in the estimation of restenosis risk after elective percutaneous transluminal coronary angioplasty. Am J Cardiol 1989;62:30–34.

  97. 97.

    Ellis SG, Shaw RE, Gershony G. Risk factors, time course and treatment effect of restenosis after successful percutaneous transluminal coronary angioplasty of chronic total occlusion. Am J Cardiol 1989;63:897–901.

  98. 98.

    Epstein S, Siegall C, Biro S, Fu Y, Fitzgerald D, Pastan I. Cytotoxic effects of recombinant chimeric toxin on rapidly proliferating vascular smooth muscle cells. Circulation 1991;84:778–787.

  99. 99.

    Epstein SE, Speir E, Unger EF, Guzman RJ, Finkel T. The basis of molecular strategies for treating coronary restenosis after angioplasty. J Am Coll Cardiol 1994;23:1278–1288.

  100. 100.

    Essed CE, van den Brand M, Becker AE. Transluminal coronary angioplasty and early restenosis: Fibrocellular occlusion after wall laceration. Br Heart J 1983;49:393–396.

  101. 101.

    Fager F, Hansson GK, Gown AM, Larson DM, Skalli O, Bondjers G. Human arterial smooth muscle cells in culture: Inverse relationship between proliferation and expression of contractile proteins. In Vitro Cell Dev Biol 1989;25:511–520.

  102. 102.

    Falk E. Unstable angina with fatal outcome: Dynamic coronary thrombosis leading to infarction and/or sudden death: Autopsy evidence of recurrent mural thrombosis with peripheral embolization culminating in total vascular occlusion. Circulation 1985;71:699–708.

  103. 103.

    Falk E. Why do plaques rupture? Circulation 1992;86(Suppl III):III30-III42.

  104. 104.

    Fanelli C, Aronoff R. Restenosis following coronary angioplasty. Am Heart J 1990;119:357–368.

  105. 105.

    Farb A, Virmani R, Atkinson JB, Kolodgie FD. Plaque morphology and pathologic changes in arteries from patients dying after coronary balloon angioplasty. J Am Coll Cardiol 1990;16:1421–1429.

  106. 106.

    Faulkner SL, Fisher RD, Conkle DM, Page DL, Bender HW. Effect of blood flow rate on subendothelial proliferation in venous autografts used as arterial substitutes. Circulation 1975;51 & 52(Suppl I):I163-I172.

  107. 107.

    Faxon DP, Sanborn TA, Haudenschild CC. Mechanism of angioplasty and its relation to restenosis. Am J Cardiol 1987;60:5B-9B.

  108. 108.

    Faxon DP, Sanborn TA, Haudenschild CC, Ryan TJ. Effect of antiplatelet on restenosis after experimental angioplasty. Am J Cardiol 1984;53:72C-76C.

  109. 109.

    Faxon DP, Sanborn TA, Weber UJ, et al. Restenosis after transluminal angioplasty in experimental atherosclerosis. Atherosclerosis 1984;4:189–195.

  110. 110.

    Faxon DP, Weber VJ, Haudenschild CC, Gottsman SB, McGovern WA, Ryan TJ. Acute effects of transluminal angioplasty in three experimental models of atherosclerosis. Atherosclerosis 1982;2:125–133.

  111. 111.

    Ferns G, Raines E, Sprugel K, Motani A, Reidy MA, Ross R. Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF. Science 1191;253:1129–1132.

  112. 112.

    Flugelman MY, Correa R, Yu ZX, et al. Fibroblast growth factors are expressed in coronary lesions of patients with unstable angina pectoris and those who have post angioplasty restenosis (abstr). J Am Coll Cardiol 1991;17:73A.

  113. 113.

    Foley DP, Serruys PW. Restenosis after percutaneous interventions: The evolving angiographics perspective. Cor Art Dis 1993;4:1129–1136.

  114. 114.

    Forrester JS, Fishbein M, Helfant R, Fagin J. A paradigm for restenosis based on cell biology: Clues for the development of new preventive therapies. J Am Coll Cardiol 1991;17:758–769.

  115. 115.

    Francis GS, Cohn JN. Heart failure: Mechanisms of cardiac and vascular dysfunction and the rationale for pharmacologic intervention. FASEB J 1990;4:3068–3075.

  116. 116.

    Franklin SM, Faxon DP. Pharmacologic prevention of restenosis after coronary angioplasty: Review of the randomized clinical trials. Cor Art Dis 1993;4:232–242.

  117. 117.

    French BA. Gene transfer and cardiovascular disorders. Herz 1993;18:222–229.

  118. 118.

    Frid DJ, Fortin DF, Lam LC, Harlan WR, Navetta FI, Smith JE. Effects of unstable symptoms on restenosis (abstr). Circulation 1990;82(Suppl 3):III427.

  119. 119.

    Friedman MD, Deters OJ, Bargeron CB, Hutchins GM, Mark FF. Shear-dependent thickening of the human arterial intima. Atherosclerosis 1986;60:161–171.

  120. 120.

    Fry DL. Responses of the arterial wall to certain physical factors. Ciba Found Symp 1973;12:93–125.

  121. 121.

    Furchgott RF. Role of endothelium in response of vascular smooth muscle. Circ Res 1983;53:557–573.

  122. 122.

    Furchgott RF, Cherry PD, Zawadzki JV, Jothianandan D. Endothelial cells as mediators of vasodilation of arteries. J Cardiovasc Pharmacol 1984;6:S336-S343.

  123. 123.

    Fuster V, Badimon JJ, Chesebro JH. The pathogensis of coronary artery disease and the acute coronary syndromes. N Engl J Med 1992;326:242–250.

  124. 124.

    Fuster V, Badimon L, Badimon JJ, Ip JH, Chesebro JH. The porcine model for the understanding of thrombosis and atherogenesis. Mayo Clinic Proceedings 1991;66:818–831.

  125. 125.

    Ganguly A, Chiou S, West LA, Davis JS. Atrial natriuretic factor inhibits angiotensin-induced aldosterone secretion: Not through cGMP or interference with propholipase. Biochem Biophys Res Commun 1989;159:148–154.

  126. 126.

    Garatt KN, Holmes DR, Bell MR, et al. Restenosis after directional coronary atherectomy: Differences between primary atheromatous and restenosis lesions and influences of subintimal tissue resection. J Am Coll Cardiol 1990;16:1665–1671.

  127. 127.

    Garg UC, Hassid A. Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 1989;83:1774–1777.

  128. 128.

    Garratt KN, Edwards W, Vlietstra RE, Kaufmann UP, Holmes DR. Coronary morphology after percutaneous directional coronary atherctomy in humans: Autopsy analysis of three patients. J Am Coll Cardiol 1990;16:1432–1436.

  129. 129.

    Garratt KN, Edwards WD, Kaufmann UP, Vlietstra RE, Holmes DR. Differential histopathology of primary atherosclerotic and restenosis lesions in coronary arteries and saphenous vein bypass grafts: Analysis of tissues obtained from 73 patients by directional atherectomy. J Am Coll Cardiol 1991;17:442–448.

  130. 130.

    Garratt KN, Holmes DR, Bell MR, et al. Restenosis after directional coronary atherectomy: Differences between primary atheromatous and restenosis lesions and influence of subinitimal tissue reacion. J Am Coll Cardiol 1990;16:1665–1671.

  131. 131.

    Geary RL, Kohler TR, Vergel S, Kirkman TR, Clowes AW. Time course of flow-induced smooth muscle cell proliferation and intimal thickening in endothelialized baboon vascular grafts. Circ Res 1994;74:14–23.

  132. 132.

    Geisterfer AAT, Peach MJ, Owens GK. Angiotensin II induces hypertrophy not hyperplasia of cultured rat aortic smooth muscle cells. Circ Res 1988;62:749–756.

  133. 133.

    Gibbons GH. Preventative treatment of graft coronary vascular disease: The potential role of vasodilator therapy. J Heart Lung Transplant 1992;11:S22-S27.

  134. 134.

    Gibbons GH. Angiotensin-converting enzyme inhibition and vascular structure in hypertension. J Cardiovasc Pharmacol 1995;18(Suppl 7):S19-S24.

  135. 135.

    Gibbons GH, Dzau VJ. Angiotensin converting enzyme inhibition and vascular hypertrophy in hypertension. Cardiovasc Drugs Ther 1990;4:237–242.

  136. 136.

    Gibbons GH, Dzau VJ. The emerging concept of vascular remodeling. N Engl J Med 1994;320:1431–1438.

  137. 137.

    Gibbons GH, Pratt RE, Dzau VJ. Angiotensin II is a bifunctional vascular smooth muscle cell growth factor (abstr). Hypertension 1989;14:358a.

  138. 138.

    Gibbons GH, Pratt RE, Dzau VJ. Vascular smooth muscle cell hypertrophy vs. hyperplasia: Autocrine transforming growth factor-B expression determines growth to angiotensin II. J Clin Invest 1992;90:456–461.

  139. 139.

    Gibson CM, Kuntz RE, Nobuyoshi M, Rosner B, Baim DS. Lesion-to-lesion independence of restenosis following treatment by conventional angioplasty, stenting, or directional atherectomy: Validation of lesion-based restenosis analysis. Circulation 1993;87:1123–1129.

  140. 140.

    Giraldo AA, Esposos OM, Meis JM. Intimal hyperplasia as a cause of restenosis after percutaneous transluminal coronary angioplasty. Arch Pathol Lab Med 1985;109:173–175.

  141. 141.

    Glagov S. Intimal hyperplasia, vascular modeling, and the restenosis problem. Circulation 1994;89:2888–2891.

  142. 142.

    Glagov S, Grande J, Vesselinovitch D, Zairns CK. Quantitation of cells and fibers in histologic sections of arterial walls: Advantages of contour tracing on a digitizing plate. In: McDonald TF, Chandler AB, eds. Connective Tissues in Arterial and Pulmonary Disease 1981:57–93.

  143. 143.

    Glagov S, Weisenberg E, Zarins CK, Stankunavicies R, Kolettis GJ. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med 1987;316:1371–1375.

  144. 144.

    Glagov S, Zarins C. Quantitating atherosclerosis: Problems of definition. In: Bond MD, Insull W, Glagov S, Chandler AB, Cornhill JF, eds. Clinical Diagnosis of Atherosclerosis: Quantitative Methods of Evaluation. New York: Springer-Verlag. 1983:11–35.

  145. 145.

    Glagov S, Zarins C, Giddens DP, Ku DN. Hemodynamics and atherosclerosis: Insights and perspectives gained from studies of human arteries. Arch Pathol Lab Med 1988;112:1018–1031.

  146. 146.

    Glagov S, Zarins CK. Is intimal hyperplasia an adaptive response or a pathologic process? J Vasc Surg 1989;10:571–573.

  147. 147.

    Gohlke P, Lamberty V, Kuwer I, Bartenbach S, Schnell A, Unger T. Vascular remodeling in systemic hypertension. Am J Cardiol 1993;71:2E-7E.

  148. 148.

    Goldberg ID, Stemerman MB. Vascular permeation of platelet factor 4 after endothelial injury. Science 1980;209:611–612.

  149. 149.

    Goodnight SH. The effects of n-3 fatty acids on atherosclerosis and the vascular response to injury. Arch Pathol Lab Med 1993;117:102–106.

  150. 150.

    Gordon D, Reidy M, Benditt E, Schwartz S. Cell proliferation in human coronary arteries. Proc Natl Acad Sci USA 1990;13:157–224.

  151. 151.

    Gore RG, Jones R. Pulmonary vascular reactivity in hypoxic pulmonary hypertension in the rat. J Appl Physiol 1988;65:2617–2623.

  152. 152.

    Gospodarowicz D, Ferrera N, Schwigerer L, Neufeld G. Structural characterization and biological functions of fibroblast growth factor. Endocrinol Rev 1987;60:755–764.

  153. 153.

    Gould KL, Lipscomb K, Hamilton GW. Physiological basis for assessing critical coronary stenosis: Instantaneous flow response and regional distribution during coronary hyperemia as measures of coronary flow reserve. Am J Cardiol 1974;13:665–672.

  154. 154.

    Gown AM, Tsukuda T, Ross R. Human atherosclerosis. II. Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions. Am J Pathol 1986;125:191–207.

  155. 155.

    Gown AM, Vogel AM, Gordon D, Lu PL. A smooth musclespecific monoclonal antibody recognizes smooth muscle actin isozymes. J Cell Biol 1985;100:807–813.

  156. 156.

    Gravanis MB, Roubin GS. Histopathologic phenomena at the site of percutaneous transluminal angioplasty: The problem of restenosis. Hum Pathol 1989;20:477–485.

  157. 157.

    Grunwald J, Chobanian A, Haudenschild CC. Smooth muscle cell migration and proliferation: Atherogenic mechanisms in proliferation. Atherosclerosis 1984;4:183–188.

  158. 158.

    Grunwald J, Haudenschild CC. Intimal injury in-vivo activates vascular smooth muscle cell migration and explant outgrowth in-vitro. Arteriosclerosis 1984;4:183–188.

  159. 159.

    Guyten JR, Karnovsky MJ. Smooth muscle cell proliferation in the occluded rat carotid artery. Am J Pathol 1979;94:585–602.

  160. 160.

    Hampl V, Archer SL, Nelson DP, Weir EK. Chronic EDRF inhibition and hypoxia: Effects on pulmonary circulation and systemic blood pressure. J Appl Physiol 1993;75:1748–1757.

  161. 161.

    Hanke H, Haase KK, Hanke S, et al. Morphological changes and smooth muscle cell proliferation after experimental excimer laser treatment. Circulation 1991;83:1380–1389.

  162. 162.

    Hanke H, Strohschneider T, Oberhoff M, Betz E, Karsch KR. Time course of smooth muscle cell proliferation in the intima and media of arteries following experimental angioplasty. Circ Res 1990;67:651–659.

  163. 163.

    Hansson GK, Bondjers G. Endothelial dysfunction and injury in atherosclerosis. Acta Med Scand Suppl 1986;715:11–17.

  164. 164.

    Harrison CV, Wood P. Hypertensive and ischemic heart disease: A comparative clinical and pathological study. Br Heart J 1949;11:205–229.

  165. 165.

    Harrison DG. Endothelial modulation of vascular tone: Relevance to coronary angioplasty and restenosis. J Am Coll Cardiol 1991;17(Suppl B):71B-76B.

  166. 166.

    Hassoun PM, Thompson BT, Steigman D, Hales CA. Effect of heparin and warfarin on chronic hypoxic pulmonary hypertension and vascular remodeling in the guinea pig. Am Rev Respir Dis 1989;139:763–768.

  167. 167.

    Haudenschild CC. Pathogenesis of restenosis. A correlation of clinical observation with cellular responses. Z Kardiol 1990;79(Suppl 3):17–22.

  168. 168.

    Haudenschild CC. Pathobiology of restenosis after angioplasty. Am J Med 1993;94:40S-44S.

  169. 169.

    Haudenschild CC, Grunwald J. Proliferative heterogeneity of vascular smooth muscle cells and its alteration by injury. Exp Cell Res 1985;157:364–370.

  170. 170.

    Haudenschild CC, Schwartz SM. Endothelial regeneration: II. Restitution of endothelial constitution. Lab Invest 1979;41:407–418.

  171. 171.

    Haust M, More R, Movat H. The role of smooth muscle cells in the fibrogenesis of arteriosclerosis. Am J Pathol 1960;37:377–389.

  172. 172.

    Haworth SG. Pulmonary vascular remodeling in neonatal pulmonary hypertension. State of the art. Chest 1988;93(Suppl):133S-138S.

  173. 173.

    Hearn JA, Donohue BC, Ba'albaki H, Douglas JD, King SB, Lembo NJ. Usefulness of serum lipoprotein (a) as a predictor of restenosis after percutaneous transluminal coronary angioplasty. Am J Cardiol 1992;69:736–739.

  174. 174.

    Hedin U, Johan T. Plasma fibronectin promotes modulation of arterial smooth-muscle cells from contractile to synthetic phenotype. Differentiation 1987;33:239–246.

  175. 175.

    Hermiler JB, Tenaglia AN, Kisslo KB, Phillips HR, Bashore TM, Davidson CJ. In vivo validation of compensatory enlargement of atherosclerotic coronary arteries. Am J Cardiol 1993;71:665–668.

  176. 176.

    Herrman JP, Hermans WR, Vos J, Serruys PW. Pharmacological approaches to the prevention of restenosis following angioplasty. The search for the Holy Grail? Drugs 1993;46:18–52.

  177. 177.

    Hirata Y, Eguchi S, Tsujino M. Effects of manidipine on DNA and protein synthesis is cultured vascular smooth muscle and endothelial cells and on proto-oncogene expression. Blood Pressure 1992;3:30–35.

  178. 178.

    Hirshfeld JW, Schwartz JS, Jugo R, et al. Restenosis after coronary angioplasty: A multivariate statistical model to relate lesion and procedure variables to restenosis. J Am Coll Cardiol 1991;18:647–656.

  179. 179.

    Hoberg E, Kubler W. Calcium-antagonists in preventing restenosis following coronary angioplasty. Cardiologia 1991;36(Suppl 1):225–227.

  180. 180.

    Hollman J, Austin GE, Gruentzig AR, Douglas JS, King SB. Coronary artery spasm at the site of angioplasty in the first 2 months after successful percutaneous transluminal coronary angioplasty. J Am Coll Cardiol 1983;2:1039–1045.

  181. 181.

    Hollman J, Gruentzig AR, Meier B, Bradford S, Galan K. Factors affecting recurrence after successful coronary angioplasty (abstr). J Am Coll Cardiol 1983;1:644.

  182. 182.

    Holman E. Problems in the dynamics of blood flow. I. Condition controlling collateral circulation in the presence of an arteriovenous fistula following the ligation of an artery. Surgery 1949;26:889–917.

  183. 183.

    Holmes DR, Schwartz RS. Restenosis: The clinical problem. Coro Art Dis 1993;4:229–231.

  184. 184.

    Hort W, Lichti H, Klabfleisch H. The size of human coronary arteries depends on the physiological and pathological growth of the heart, the age, the size of the supplying areas and the degree of coronary sclerosis: A postmortem study. Virchows Arch 1982;397:37–59.

  185. 185.

    Hutchins GM, Bulkley BH, Miner MM, Boitnott JK. Correlation of age and heart weight with tortuosity and caliber of normal human coronary arteries. Am Heart J 1977;94:196–202.

  186. 186.

    Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 1987;84:9265–9269.

  187. 187.

    Ignarro LJ, Byrns RE, Buga GG, Wood KS, Chaudhuri G. Pharmacological evidence that endothelium-derived relaxation factor is nitric oxide: Use of pyrogallol and superoxide dismutase to study endothelium-dependent and nitric oxide-elicited vascular smooth muscle relaxation. J Pharmacol Exp Ther 1988;244:181–189.

  188. 188.

    Ignarro LJ, Lippton H, Edwards JC, et al. Mechanisms of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: Evidence for the involvement of S-nitrosothiols as active intermediates. J Pharmacol Exp Ther 1981;218:739–749.

  189. 189.

    Ignotz A, Massague J. Transforming growth factor-B stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J Biol Chem 1986;261:4337–4345.

  190. 190.

    Ingber D. Integrins as mechanochemical transducers. Curr Opin Cell Biol 1991;3:841–848.

  191. 191.

    Ip J, Fuster V, Israel D, Badimon L, Badimon J, Taubman M, Chesebro JH. Syndromes of accelerated atherosclerosis: Role of vascular injury and smooth muscle proliferation. J Am Coll Cardiol 1990;15:1667–1687.

  192. 192.

    Ip JH, Fuster V, Israel D, Badimon L, Badimon J, Chesebro JH. The role of platelets, thrombin and hyperplasia in restenosis after coronary angioplasty. J Am Coll Cardiol 1991;17(Suppl B):77B-88B.

  193. 193.

    Isner JM. Vascular remodeling: Honey, I think I shrunk the artery. Circulation 1994;89:2937–2941.

  194. 194.

    Isner JM, Brinker JA, Gottlieb RD, Leya F, Masden RR, Shani J. Coronary thrombus: Clinical features and angiographic diagnosis in 370 patients studied by directional atherectomy (abstr). Circulation 1992;86(Suppl I):1–649.

  195. 195.

    Isner JM, Donaldson RF, Fortin AH. Attentuation of the media of coronary arteries in advanced atherosclerosis. Am J Cardiol 1986;58:937–939.

  196. 196.

    Isner JM, Kearney M, Bortman S, Pickering JG, Riessen R, Topol EJ. Sequential biopsy of human atheromata in vivo: Longitudinal analysis of atheromatous coronary arterial wall in 11 patients treated for primary and restenosis lesions by directional atherectomy (abstr). J Am Coll Cardiol 1993;21:74A.

  197. 197.

    Isner JM, Rosenfield K, Losordo DW, et al. Combination balloon-ultrasound imaging catheter for percutaneous transluminal angioplasty: Validation of imaging, analysis of recoil, and identification of plaque fracture. Circulation 1991;84:739–754.

  198. 198.

    Isner JM, Kearney M, Bortman S, Passeri J. Apoptosis in human atherosclerosis and restenosis. Circulation 1995;91:2703–2711.

  199. 199.

    Itoh H, Mukoyama M, Pratt RE, Gibbons GH, Dzau VJ. Multiple autocrine growth factors modulate vascular smooth muscle cell growth response to angiotensin II. J Clin Invest 1993;91:2268–2274.

  200. 200.

    Itoh H, Pratt RE, Dzau VJ. Atrial natriuretic polypeptide inhibits hypertrophy of vascular smooth muscle cells. J Clin Invest 1990;86:1690–1697.

  201. 201.

    Itoh H, Pratt RE, Dzau VJ. Antisense oligonucleotides complementary to PDGF mRNA attenuate angiotensin II-induced hypertrophy (abstr). Hypertension 1990;16:325.

  202. 202.

    Itoh H, Pratt RE, Gibbons GH, Dzau VJ. Angiotensin II modulates proliferation of vascular smooth muscle cells (VSMC) via dual autocrine loops of transforming growth factor beta and basic fibroblast growth factor (abstr). Council for High Blood Pressure Research 1991.

  203. 203.

    Itoh H, Suga S, Ogawa Y, Tanaka I, Nakao K. Molecular biology and pharmacology of natriuretic peptide system. Nippon Rinsho 1993;51:1548–1556.

  204. 204.

    Iwatsuki K, Cardinale GJ, Spector S, Udenfriend S. Hypertension: Increase of collagen biosynthesis in arteries but not in veins. Science 1977;198:403–405.

  205. 205.

    Jackson CI, Schwartz SM. Pharmacology of smooth muscle cell replication. Hypertension 1992;20:713–736.

  206. 206.

    Jamal A, Bendeck MP, Langille BL. Structural changes and recovery of function after arterial injury. Arterioscler Thromb 1992;12:307–317.

  207. 207.

    Johnson A, Lermioglu F, Garg UC, Morgan-Boyd R, Hassid A. A novel biological effect of atrial natriuretic hormone: Inhibition of mesangial cell mitogenesis. Biochem Biophys Res Commun 1988;152:893–897.

  208. 208.

    Johnson DE, Hinohara T, Selmon MR, Braden LJ, Simpson JB. Primary peripheral arterial stenoses and restenoses excised by transluminal atherectomy: A histopathologic study. J Am Coll Cardiol 1990;15:419–425.

  209. 209.

    Johnson DE, Selmon MR, Simpson JB. Primary stenoses and restenoses excised by peripheral atherectomy: A histologic study (abstr). J Am Coll Cardiol 1988;11:173A.

  210. 210.

    Johnson KW. Femoral and popliteal arteries; re-analysis of results of balloon angioplasty. Radiology 1992;183:767–777.

  211. 211.

    Kakuta T, Currier JW, Bier JD, Faxon DP. The impact of arterial remodeling on the chronic lumen size after angioplasty in the atherosclerotic rabbit (abstr). J Am Coll ardiol 1994;23:138A.

  212. 212.

    Kakuta T, Currier JW, Haudenschild CC, Ryan TJ, Faxon DP. Differences in compensatory vessel enlargement, not intimal formation, account for restenosis after angioplasty in the hypercholesterolemic rabbit model. Circulation 1994;89:2809–2815.

  213. 213.

    Kamiya A, Togawa T. Adaptive regulation of wall shear stress to flow change in the canine carotid artery. Am J Physiol 1990;239:H14-H21.

  214. 214.

    Karas SP, Santoian EC, Gravanis MB. Restenosis following coronary angioplasty. Clin Cardiol 1991;14:791–801.

  215. 215.

    Kariya K, Kawahara Y, Tsuda T, Fukuzaki H, Takai Y. Possible involvement of protein kinase C in platelet-derived growth factor-stimulated DNA synthesis in vascular smooth muscle cells. Atherosclerosis 1987;63:251–255.

  216. 216.

    Kato T, Kitamura H, Kanisawa M. Comparative effects of isosorbide dinitrate, prednisolone, indomethacin, and elastase on the development of monocrotaline-induced pulmonary hypertension. Exp Mol Pathol 1989;50:303–315.

  217. 217.

    Kelm M, Feelisch R, Spahr M, Piper M, Noack E, Schrader J. Quantitative and kinetic characterization of nitric oxide and EDRF released from cultured endothelial cells. Biochem Biophys Res Commun 1988;154:236–244.

  218. 218.

    Kerber RE, Armstrong ML, Kieso RA, Smith RS, Tompkins PK. Compensatory enlargement (remodeling) of atherosclerotic arteries is time dependent in rabbits (abstr). Circulation 1993;88(Suppl I):1521.

  219. 219.

    Kerr A, Bommer WJ, Pilato S. Coronary artery enlargment in experimental cardiac hypertrophy. Am Heart J 1968;75:144.

  220. 220.

    Keski-Oja J, Lyons RM, Moses HL. Immunodetection and modulation of cellular growth with antibodies against native transforming growth factor-B. Cancer Res 1987;47:6451–6458.

  221. 221.

    King JF, Manley JC, al-Wathiqui MH. Restenosis after angioplasty: Mechanisms and clinical experience. Cardiol Clin 1989;7:853–864.

  222. 222.

    Ko C, Glagov S, Zarins CK. Structural basis for the compensatory enlargment of arteries during early atherogenesis. In: Bortatti E, ed. Proceedings of 3rd International Workshop of Vascular Hemodynamics (Bologna 1991). Milan: Centro Scientifico Editore, 1992:157–161.

  223. 223.

    Kockx MM, Cambier BA, Bortier HE, DeMeyer GR, van Cauwelaert PA. The modulation of smooth muscle cell phenotype is an early event in human aorto-coronary saphenous vein grafts. Virchows Arch A Pathol Anat Histopathol 1992;420:155–162.

  224. 224.

    Kohchi K, Takebayashi S, Block PC, Hiroki T, Nobuyoshi M. Arterial changes after percutaneous transluminal coronary angioplasty: Results at autopsy. J Am Coll Cardiol 1987;10:592–599.

  225. 225.

    Kohler TR, Jawein A. Flow affects development of intimal hyperplasia after arterial injury in rats. Arterioscler Thromb 1992;12:963–971.

  226. 226.

    Komuro I, Katoh Y, Kaida T, et al. Mechanical loading stimulated cell hypertrophy and specific gene expression in cultured rat cardiac myocytes. Possible role of protein kinase C activation. J Biol Chem 1991;226:1265–1268.

  227. 227.

    Kovach JA, Mintz GS, Kent KM, et al. Serial intravascular ultrasound studies indicate that chronic recoil is an important mechanism of restenosis following transcatheter therapy (abstr). J Am Coll Cardiol 1993;21:484A.

  228. 228.

    Ku DN, Giddens DP, Zarins CK, Glagov S. Pulsatile flow and atherosclerosis in human carotid bifurcation: Positive correlation between plaque location and low and oscillating shear stress. Arteriosclerosis 1985;5:292–302.

  229. 229.

    Kuchan MJ, Frangos JA. Shear stress regulates endothelin-1 release via protein kinase C and cGMP in cultured endothelial cells. Am J Physiol 1993;264:H150-H156.

  230. 230.

    Kuntz RE, Baim DS. Defining coronary restenosis: Newer clinical and angiographic paradigms. Clin Concepts Cor Restenos 1993;88:1310–1320.

  231. 231.

    Kuntz RE, Gibson CM, Nobuyoshi M, Bain DS. Generalized model of restenosis after conventional balloon angioplasty, stenting and directional atherectomy. J Am Coll Cardiol 1993;21:15–25.

  232. 232.

    Kuntz RE, Hinohara T, Safian RD, Selmon MR, Simpson JB, Baim DS. Restenosis after directional coronary angioplasty: Effects of luminal diameter and deep wall excision. Circulation 1992;86:1394–1399.

  233. 233.

    Kuntz RE, Safian RD, Carrozza JP, Fishman RF, Mansour M, Baim DS. The importance of acute luminal diameter in determining restenosis after coronary atherectomy or stenting. Circulation 1992;86:1827–1835.

  234. 234.

    Kuntz RE, Safian RD, Levin MJ, Reis GJ, Diver DJ, Baim DS. Novel approach to the analysis of restenosis following three new coronary interventions. J Am Coll Cardiol 1992;19:1493–1499.

  235. 235.

    Kuntz RE, Schmidt DA, Levine MJ, Reis GJ, Diver DJ, Baim DS. Importance of post-procedure luminal diameter on restenosis following new coronary intervations (abstr). Circulation 1990;82(Suppl III):III1245.

  236. 236.

    Lafont AM, Chisolm GM, Whitlow PL, Goormastic M, Cornhill JF. Post-angioplasty restenosis in the atherosclerotic rabbit: Proliferative response or chronic constriction? Circulation 1993;88(Suppl I):I521.

  237. 237.

    Lane TF, Iruela-Arispe ML, Johnson RS, Sage EH. SPARC is a source of copper-binding peptides that stimulate angiogenesis. J Cell Biol 1994;125:929–943.

  238. 238.

    Lange RA, Willard JE, Hillis LD. Southwestern Internal Medicine Conference: Restenosis: The Achilles heel of coronary angioplasty. Am J Med Sci 1993;306:265–275.

  239. 239.

    Langille BL, O'Donnell F. Reductions in arterial diameter produced by chronic decreases in blood flow are endothelium-dependent. Science 1986;231:405–407.

  240. 240.

    Langille BC, Bendeck MB, Keeley FW. Adaptations of carotid arteries of young and mature rabbits to reduced carotid blood flow. Am J Physiol 1989;256:H931-H939.

  241. 241.

    La Veau P, Sarembock I, Sigal S, Yang T, Ezekowitz M. Vascular reactivity after balloon angioplasty in the atherosclerotic rabbit. Circulation 1190;82:1790–1801.

  242. 242.

    Lawrie GM, Lie JT, Morris GC, Beazley HC. Vein graft patency and intimal proliferation after aorto-coronary bypass: Early and long-term angiopathologic correlations. Am J Cardiol 1976;38:856.

  243. 243.

    Leclerc G, Isner J, Kearney M. Evidence implicating nonmuscle myosin in restenosis: Use of in situ hybridization to analyze human vascular lesions obtained by directional atherectomy. Circulation 1992;85:542–553.

  244. 244.

    Lee PC, Gibbons GH, Dzau VJ. Cellular and molecular mechanisms of coronary artery restenosis. Cor Art Dis 1993;4:254–259.

  245. 245.

    Lehmann KH, von Segesser L, Muller-Glauser W. Internal-mammary coronary artery grafts: Is their superiority also due to a basically intact endothelium? Thorac Cardiovasc Surg 1989;37:187–189.

  246. 246.

    Leibovich SJ, Ross R. A micro-phage dependent factor that stimulates the proliferation of fibroblasts in vitro. Am J Pathol 1976;84:501–513.

  247. 247.

    Leimgruber PP, Roubin GS, Anderson HV, et al. Influence on intimal dissection on restenosis after successful coronary angioplasty. Circulation 1985;72:530–535.

  248. 248.

    Leimgruber PP, Roubin GS, Hollman J, et al. Restenosis after successful coronary angioplasty in patients with single vessel disease. Circulation 1986;73:710–717.

  249. 249.

    Levy BI, Michael JB, Salzmann JL, et al. Effects of chronic inhibitions of converting enzyme on mechanical and structural properties of arteries in rat renovascular hypertension. Circ Res 1988;63:227–239.

  250. 250.

    Lewis BS, Gotsman MS. Relation between coronary artery size and left ventricular wall mass. Br Heart J 1973;35:1150–1153.

  251. 251.

    Libby P, Schwartz D, Brogi E, Tanaka H, Clinton SK. A cascade model for restenosis. A special case of atherosclerosis progression. Circulation 1992;86(Suppl):III47-III52.

  252. 252.

    Lichtlen PR, Hugenholtz PG, Rafflenbeul W, Hecker H, Jost S, Deckers JW. Retardation of angiographic progression of coronary artery disease by nifedipine: Results of the International Nifedipine Trial in Antiatherosclerotic Therapy (INTACT). Lancet 1990;335:1109–1113.

  253. 253.

    Liebow AA. Situations which lead to changes in vascular patterns. In: Handbook of Physiology. Am Physiol Soc 1963;Circulation 2:1251–1276.

  254. 254.

    Lincoff AM, Popma JJ, Ellis SG, Hacker JA, Topol EJ. Abrupt vessel closure complicating coronary angioplasty: Clinical, angiographic and therapeutic profiles. J Am Coll Cardiol 1992;19:926–935.

  255. 255.

    Linder V, Reidy MA. Expression of basic fibroblast growth factor and its receptor by smooth muscle cells on endothelium in injured rat arteries. Circ Res 1993;73:589–595.

  256. 256.

    Lindner E, Reidy M. Proliferation of smooth muscle cells after vascular injury is inhibited by an antibody against basic fibroblast growth factor. Proc Natl Acad Sci USA 1991;88:3739–3743.

  257. 257.

    Lindner V, Reidy MA, Fingerle J. Regrowth of arterial endothelium. Denudation with minimal trauma leads to complete endothelial cell regrowth. Lab Invest 1989;61:556–563.

  258. 258.

    Liptay MJ, Parks WC, Mecham RP, et al. Neointimal macrophages co-localize with extracellular matrix gene expression in human atherosclerotic pulmonary arteries. J Clin Invest 1993;91:588–594.

  259. 259.

    Litvak F. Intravascular stenting for prevention of restenosis: In search of the magic bullet. J Am Coll Cardiol 1989;13:1092–1093.

  260. 260.

    Liu MW, Rubin GS, King SB. Restenosis after coronary angioplasty. Potential biologic determinants and role of intimal hyperplasia. Circulation 1989;79:1373–1387.

  261. 261.

    Losordo DW, Rosenfield K, Kaufman J, Pieczek A, Isner JM. Focal compensatory enlargement of human arteries in response to progressive atherosclerosis. Circulation 1994;89:2570–2577.

  262. 262.

    Losordo DW, Rosenfield K, Pieczek A, Baker K, Harding M, Isner JM. How does angioplasty work? Serial analysis of human iliac arteries using intravascular ultrasound. Circulation 1992;86:1845–1858.

  263. 263.

    Lovqvist A, Emanuelsson H, Nilsson J, Lundqist H, Carlson J. Pathophysiological mechanisms for restenosis following coronary angioplasty: Possible preventative alternatives. J Intern Med 1993;233:2125–226.

  264. 264.

    Lyon RT, Zarins CK, Lu CT, Yang CF, Glagov S. Vessel, plaque and lumen morphology after transluminal balloon angioplasty. Quantitative study in distended human arteries. Arteriosclerosis 1987;7:306–314.

  265. 265.

    Madri JA, Reidy MA, Kocher O, Bell L. Endothelial cell behavior after denudation injury is modulated by transforming growth factor-beta and fibronectin. Lab Invest 1989;60:755–765.

  266. 266.

    Majack RA. Beta-type transforming growth factor specifies organizational behavior in vascular smooth muscle cell cultures. J Cell Biol 1987;105:465–471.

  267. 267.

    Majack RA, Goodman LV, Dixit VM. Cell surface thrombospondin is functionally essential for vascular smooth muscle cell proliferation. J Cell Biol 1988;106:415–422.

  268. 268.

    Majesky MW. Neointima formation after acute vascular injury. Role of counteradhesive extracellular matrix proteins. Tex Heart Inst J 1994;21:78–85.

  269. 269.

    Majesky MW, Lindner V, Twardzik DR, Schwartz SM, Reidy MA. Production of transforming growth factor B1 during repair of arterial injury. J Clin Invest 1991;88:904–910.

  270. 270.

    Marcum JA, Reilly CF, Rosenberg RD. Heparin sulfate species and blood vessel wall function. Biol Proteoglycans 1987 301–343.

  271. 271.

    Massague J. The TGF-B family of growth and differentiation factors. Cell 1987;49:437–438.

  272. 272.

    Massmann J, Oestreich S. Angiometric studies of human coronary artery sclerosis. Atherosclerosis 1974;20:287–294.

  273. 273.

    Matsi PJ, Manninen HI, Sahonen MT, Pirinen AE, Soimakallio S. Chronic critical lower-limb ischemia: Prospective trial of angioplasty with 1–36 month follow-up. Radiology 1993;188:381–387.

  274. 274.

    Mauro VF, Frazee LA. Use of fish oil to prevent coronary angioplasty restenosis. Ann Pharmacother 1992;26:1541–1545.

  275. 275.

    Mazur W, Ali NM, Raizner AE, French BA. Coronary restenosis and gene therapy. Tex Heart Inst J 1994;21:104–111.

  276. 276.

    McBride W, Lange RA, Hillis LD. Restenosis after successful coronary angioplasty. Pathophysiology and prevention. N Engl J Med 1988;318:1734–1737.

  277. 277.

    McPherson DD, Armstrong M, Rose E. High-frequency epicardial echocardiography for arterial lumen and wall thickness measurements. J Am Coll Cardiol 1986;8:600–606.

  278. 278.

    McPherson DD, Hiratzka LF, Lamberth WC. Deliniation of the extent of coronary atherosclerosis by high-frequency epicardial echocardiography. N Engl J Med 1987;316:304–309.

  279. 279.

    McPherson DD, Sirna SJ, Hiratzkja LF. Coronary arterial remodeling studied by high-frequency epicardial echocardiography: An early compensatory mechanism in patients with obstructive coronary atherosclerosis. J Am Coll Cardiol 1991;17:79–86.

  280. 280.

    Mecham RP, Whitehouse LA, Wrenn DS. Smooth muscle-mediated connective tissue remodeling in pulmonary hypertension. Science 1987;237:423–426.

  281. 281.

    Meier B. Prevention of restenosis after coronary angioplasty: A pharmacological approach. Eur Heart J 1989;10(Suppl):G64-G68.

  282. 282.

    Meier B. Restenosis after coronary angioplasty: Review of the literature. Eur Heart J 1989;9(Suppl C):1–6.

  283. 283.

    Meredith IT, Anderson TJ, Uehata A, Yeung AC, Seleyn AP, Ganz P. Role of endothelium in ischemic coronary syndromes. Am J Cardiol 1993;72:27C-32C.

  284. 284.

    Meyrick B, Reid L. Hypoxia-induced structural changes in the media and adventitia of the rat hilar pulmonary artery and their regression. Am J Pathol 1980;100:151–178.

  285. 285.

    Miles G, Dalessandro W. The relation of the circumference of the coronary arteries to the weight of the heart and to myocardial infarction and myocardial failure. Rev Can Biol 1963;22:325–327.

  286. 286.

    Miller MJ, Kuntz RE, Friedrich SP, et al. Frequency and consequences of intimal hyperplasia in specimens retrieved by directional atherectomy of native primary coronary artery stenosis and subsequent restenoses. J Am Coll Cardiol 1993;71:652–658.

  287. 287.

    Mintz GS, Kovach JA, Pichard AD, et al. Geometric remodeling is the predominant mechanism of clinical restenosis after coronary angioplasty (abstr). J Am Coll Cardiol 1994;23:138A.

  288. 288.

    Mintz GS, Kovach JA, Saturnino PJ, Ditrano CD, Leon MB. Geometric remodeling is the predominant mechanism of the late lumen loss after coronary angioplasty (abstr). Circulation 1993;8(Suppl I):I654.

  289. 289.

    Mintz GS, Kovach JA, Javier SP, Ditrano CJ, Leon MB. Geometric remodeling is the predominant mechanism of late lumen loss after coronary angioplasty. Circulation 1993;88(Suppl I):I654.

  290. 290.

    Monsen CH, Adams PC, Badimon L, Chesebro JH, Fuster V. Platelet-vessel wall interactions in the development of restenosis after coronary angioplasty. Z Kardiol 1987;76(Suppl 6):23–28.

  291. 291.

    More RS, Brack MJ, Gershlick AH. Heparin after angioplasty: An unresolved issue? Eur Heart J 1993;14:1453–1547.

  292. 292.

    Morris CE, Sigurdson WS. Stretch-inactivated ion channels coexist with stretch-activated ion channels. Science 1989;243:807–809.

  293. 293.

    Muller DW, Ellis SG, Topol EJ. Colchicine and antineoplastic therapy for the prevention of restenosis after percutaneous coronary interventions. J Am Coll Cardiol 1991;17(Suppl B):126B-131B.

  294. 294.

    Muller DW, Ellis SG, Topol EJ. Experimental models of coronary artery restenosis. J Am Coll Cardiol 1992;19:418–432.

  295. 295.

    Mulvany MJ. The structure of the resistance vasculature in essential hypertension. J Hypertens 1987;5:129–136.

  296. 296.

    Mulvihill DA, Harvey SC. The mechnisms of the development of collateral circulation. N Engl J Med 1931;104:1032.

  297. 297.

    Mustard JF, Packham MA, Kinlough-Rathbone RL. Platelets, blood flow, and the vessel wall. Circulation 1990;81(Suppl):I24-I27.

  298. 298.

    Naftilan AJ, Gilliland GK, Eldridge CS, Karin M, Kraft AS. Induction of the protooncogene c-jun by angiotensin II (abstr). Circulation 1989;80(Suppl II):459a.

  299. 299.

    Naftilan AJ, Pratt RE, Dzau VJ. Induction of platelet-derived growth factor A-chain and c-myc gene expression by angiotensin II in cultured rat vascular smooth muscle cells. J Clin Invest 1989;83:1419–1424.

  300. 300.

    Naruse K, Sokabe M. Involvement of stretch-activated ion channels in Ca2+ mobilization to mechanical stretch in endothelial cells. Am J Physiol 1993;264:C1037-C1044.

  301. 301.

    Nikol S, Isner JM, Pickering JG, Kearney M, Leclerc G, Weir L. Expression of transforming growth factor-B1 is increased in human vascular restenosis lesions. J Clin Invest 1992;90:1582–1592.

  302. 302.

    Nikol S, Weir L, Kearney M, Leclerc G, Donovan C, Isner J. Nonmuscle myosin: two isoforms with different functions in vascular restenosis (abstr). J Am Coll Cardiol 1992;19:166A.

  303. 303.

    Nikol S, Weir L, Sullivan A, et al. Persistent increased expression of the transforming growth factor-B1 gene in human vascular restenosis. Cardiovasc Pathol 1994;3:57–64.

  304. 304.

    Nishida K, Harrison DG, Navas JP. Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase. J Clin Invest 1992;90:2092–2096.

  305. 305.

    Nobuyoshi M, Kimura T, Ohishi H, et al. Restenosis after percutaneous transluminal coronary angioplasty: The problems of restenosis. J Am Coll Cardiol 1991;17:433–439.

  306. 306.

    Nollert MU, Eskin SG, McIntire LV. Shear stress increases inositol triphosphate levels in human endothelial cells. Biochem Biophys Res Commun 1990;170:281–287.

  307. 307.

    Nunes GL, Sgoutas DS, Sigman SR, et al. Vitamin C and E improve the response to coronary balloon injury in the pig: Effect of vascular remodeling. Circulation 1993;88(Suppl I):I372.

  308. 308.

    O'Brien ER, Alpres CE, Stewart DK, Ferguson M, Tran N, Gordon D, Benditt EP, Hinobra T, Simpson JB, Schwartz SM. Proliferation in primary and restenotic coronary atherectomy tissues: Implications for antiproliferative therapy. Circ Res 1993;73:223–231.

  309. 309.

    O'Donohoe MK, Schwartz LB, Radic ZS, Mikat EM, McCann RL, Hagen PO. Chronic ACE inhibition reduces intimal hyperplasia in experimental vein grafts. Ann Surg 1991;214:727–732.

  310. 310.

    O'Neill WW, Brodie B, Knopf W, Ivanhoe R, O'Keefe J, Taylor G. Initial report of the primary Angioplasty Revascularization (PAR) Multicenter Registry (abstr). Circulation 1991;84(Suppl 2):II536.

  311. 311.

    Ohara T, Nanto S, Asada S, Komamaru K, Wang D. Ultrastructural study of proliferating and migrating smooth muscle cells at the site of PTCA as an explanation for restenosis (abstr). Circulation 1988;78(Suppl II):II290.

  312. 312.

    Ohno M, Cooke JP, Dzau VJ, Gibbons GH. Fluid shear stress induces endothelial TGFb1 transcription and production. Modulation by calcium channel blockade. J Clin Invest 1995;95:1363–1369.

  313. 313.

    Olesen SP, Clapham DE, Davies PF. Hemodynamic shear stress activates a K+ current in vascular endothelial cells. Nature 1988;331:168–170.

  314. 314.

    Ono S, Voelkel NF. PAF receptor blockade inhibits lung vascular changes in the rat monocrotaline model. Lung 1992;170:31–40.

  315. 315.

    Ono S, Westcott JY, Voelkel NF. PAF antagonists inhibit pulmonary vascular remodeling induced by hypobaric hypoxia in rats. J Appl Physiol 1992;73:1084–1092.

  316. 316.

    Owens GK. Differential effects of antihypertensive therapy on vascular smooth muscle cell hypertrophy, hyperploidy, and hyperplasia in the spontaneously hypertensive rat. Circ Res 1985;56:525–536.

  317. 317.

    Owens GK. Control of hypertrophic versus hyperplastic growth of vascular smooth muscle cells. Am J Physiol 1989;257:H1755-H1765.

  318. 318.

    Owens GK, Geisterfer AAT, Yang YWH, Komoriya A. Transforming growth factor-B-induced growth inhibition and cellular hypertrophy in cultured vascular smooth muscle cells. J Cell Biol 1988;107:771–780.

  319. 319.

    Owens GK, Loeb A, Gordon D, Thomson MM. Expression of smooth muscle-specific alpha-isoactin in cultured vascular smooth muscle cells: Relationship between growth and cytodifferentiation. J Cell Biol 1986;102:343–352.

  320. 320.

    Owens GK, Reidy M. Hyperplastic growth response of vascular smooth muscle cells following induction of acute hypertension in rats by aortic coarctation. Circ Res 1985;57:695–705.

  321. 321.

    Owens GK, Schwartz SM. Alterations in vascular smooth muscle mass in the spontaneously hypertensive rat. Circ Res 1982;51:280–289.

  322. 322.

    Palmer RMJ, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988;333:664–666.

  323. 323.

    Palmer RMJ, Ferrige AG, Moncada S. Nitric oxide release accounts for the biologic activity of endothelium-derived relaxing factor. Nature 1987;327:524–526.

  324. 324.

    Panza JA, Quyyumi AA, Brush JE, Epstein SE. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med 1990;323:22–27.

  325. 325.

    Park JW, Braun P, Mertens S, Heinrich KW. Ischemia: Reperfusion injury and restenosis after coronary angioplasty. Ann NY Acad Sci 1992;669:215–236.

  326. 326.

    Parkes JL, Cardell RR, Hubbard FC, Hubbard D, Meltzer A, Penn A. Cultured human atherosclerotic plaque smooth muscle cells retain transforming potential and display enhanced expression of the myc-protooncongene. Am J Pathol 1991;138:765–775.

  327. 327.

    Pasterkamp G, Wensing PJW, Post MJ, Hillen B, Mail WPTM, Borst C. Paradoxical vessel shringage as an important mechanism of femoral artery stenosis: An intravascular ultrasound study (abstr). J Am Coll Cardiol 1994;23:242A.

  328. 328.

    Penny WJ, Chesebro JH, Heras M, Fuster V. Antithrombotic therapy for patients with cardiac disease. Curr Probl Cardiol 1988;13:433–513.

  329. 329.

    Phara T, Nanto S, Asada S, Komamura K, Wang DY. Ultrastructural study proliferating and migrating smooth muscle cells at the site of PTCA as an explanation for restenosis. Circulation 1988;78(Suppl II):II290.

  330. 330.

    Pickering JG, Weir L, Jekanowski J, Kearney M, Isner JM. Proliferative activity on peripheral and coronary atherosclerotic plaque among patients undergoing percutaneous revascularization. J Clin Invest 1993;91:1469–1480.

  331. 331.

    Pickering JG, Weir L, Rosenfield K, Stetz J, Jekanowski J, Isner JM. Smooth muscle cell outgrowth from human atherosclerotic plaque: Implications for the assessment of lesion biology. J Am Coll Cardiol 1992;20:1430–1439.

  332. 332.

    Pierce GF, Mustoe TA, Lingelbach J, et al. Platelet-derived growth factor and transforming growth factor-B enhance tissue repair activities by unique mechanisms. J Cell Biol 1989;109:249–440.

  333. 333.

    Pinto A, Miller M, McGiff JC, Mullane K. Endothelial-dependent contractions and relaxations of rabbit aorta following coarctation. Circulation 1985;72(Suppl 3):264.

  334. 334.

    Pirola CJ, Wang HM, Strgacich MI, et al. Mechanical stimuli induce vascular parathyroid hormone-related protein gene expression in vivo and in vitro. Endocrinology 1994;134:2230–2236.

  335. 335.

    Pohl U, Holtz J, Busse R, Bassenge E. Crucial role of endothelium in the vasodilator response to increased flow in vivo. Hypertension 1986;8:37–47.

  336. 336.

    Poiani GJ, Tozzi CA, Yohn SE, et al. Collagen and elastin metabolism in hypertensive pulmonary arteries of rats. Circ Res 1990;66:968–978.

  337. 337.

    Pollack A, Korte GE. Vascular remodeling after laster photocoagulation: Concurrent regeneration and atrophy. Acta Anat 1992;143:151–159.

  338. 338.

    Popma JJ, De Cesare NB, Pinkerton CA. Quantitative analysis of factors influencing late lumen loss and restenosis after directional coronary atherectomy. Am J Cardiol 1993;71:552–557.

  339. 339.

    Popma JJ, Topol EJ. Factors influencing restenosis after coronary angioplasty. Am J Med 1990;88:16N-24N.

  340. 340.

    Post M, van Erven L, Velema E, Bentala M, Borst C. Which part of the angiographic diameter reduction after balloon dilation is due to intimal hyperplasia (abstr)? J Am Coll Cardiol 1993;21(Suppl A):36A.

  341. 341.

    Post M, van Erven L, Velema E, Borst C. Restenosis is partly due to intimal hyperplasia and partly due to remodeling of the injured arterial wall (abstr). Eur Heart J 1993;14(Suppl):201.

  342. 342.

    Post MJ, Borst C, Kuntz RE. The relative importance of arterial remodeling compared with intimal hyperplasia in lumen renarrowing after balloon angioplasty: A study in the normal rabbit and the hypercholesterolemic Yucatan micropig. Circulation 1994;89:2816–2821.

  343. 343.

    Powell J, Clozel J, Muller R. Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury. Science 1989;245:186–188.

  344. 344.

    Powell J, Muller R, Baumgartner H. Supression of the vascular response to injury: The role of angiotensinconverting enzyme inhibitors. J Am Coll Cardiol 1991;17(Suppl):126B-42B.

  345. 345.

    Powell JS, Muller RK, Rouge M, Kuhn F, Baumgartner HR. The proliferative response to vascular injury is suppressed by angiotensin-converting enzyme inhibition. J Cardiovasc Pharmacol 1990;16(Suppl 4):S42-S49.

  346. 346.

    Preisack MB, Karsch KR. The paradigm of restenosis following percutaneous transluminal coronary angioplasty. Eur Heart J 1993;14(Suppl I):187–192.

  347. 347.

    Preisack MB, Karsch KR. Experimental and early clinical experience with reviparin-sodium or prevention of restenosis after percutaneous transluminal coronary angioplasty. Blood Coagul Fibrinolysis 1993;4(Suppl 1):S55-S58.

  348. 348.

    Rab ST, King SB, Roubin GS, Carlin S, Hearn JA, Douglas JS. Coronary aneurysms after stent placement: A suggestion of altered vessel wall healing in the presence of antiinflammatory agents. J Am Coll Cardiol 1991;18:1524–1528.

  349. 349.

    Raij L. Mechanisms of vascular injury: The emerging role of the endothelium. J Soc Nephrol 1991;2(Suppl):S2-S8.

  350. 350.

    Rakugi H, Gibbons G, Wang D, et al. Expression of transforming growth factor B1 in human atherectomy specimens from primary and restenotic coronary artery lesions (abstr). J Am Coll Cardiol 1992;19:329A.

  351. 351.

    Rapoport RM, Murad F. Endothelium-dependent and nitrovasodilator-induced relaxation of vascular smooth muscle: Role of cyclic GMP. J Cyclic Nucleot Prot Phosphoryl Res 1983;9:281–296.

  352. 352.

    Rasmussen LH, Gorbansch C, Lorenzen I. I: Injury and repair of smaller muscular and elastic arteries: A light microscopic study on the different healing patterns of rabbit femoral and carotid arteries following dilation injury by a balloon catheter. Virchows Arch 1987;411:87–92.

  353. 353.

    Reid LM. The control of cellular proliferation in the pulmonary circulation. Am Rev Respir Dis 1989;140:1490–1493.

  354. 354.

    Reidy MA, Clowes AW, Schwartz SM. Endothelial regeneration: V. Inhibition of endothelial regrowth in arteries of rat and rabbit. Lab Invest 1983;49:569–575.

  355. 355.

    Reidy MA, Fingerle J, Lindner V. Factors controlling the development of arterial lesions after injury. Circulation 1992;86(Suppl III):III43-III46.

  356. 356.

    Reidy MA, Standert D, Schwartz SM. Inhibition of endothelial cell regrowth: Cessation of aortic endothelial cell replication after balloon catheter denudation. Arteriosclerosis 1982;2:216–220.

  357. 357.

    Reidy MA, Walker LN. Endothelial-smooth muscle cell interaction in vivo. Vasc Dis 1987; 185–195.

  358. 358.

    Rensing BJ, Herman WRM, Deckers JW, de Feyter PJ, Tijssen JGP, Serruys PW. Lumen narrowing after percutaneous transluminal coronary balloon angioplasty follows a near gaussian distribution: A quantitative angiographic study in 1,445 successfully dilated lesions. J Am Coll Cardiol 1992;19:939–945.

  359. 359.

    Rensing BJ, Hermans WRM, Vos J, et al. Angiographic risk factors of luminal narrowing after coronary balloon angioplasty using balloon measurements to reflect stretch and recoil at the dilatation site. Am J Cardiol 1992;69:584–591.

  360. 360.

    Resnick N, Collins T, Atkinson W, Bonthron DT, Dewey CF, Gimbrone MA. Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element. Proc Natl Acad Sci USA 1993;90:7908.

  361. 361.

    Ricevuti G, Mazzone A, Pasotti D, de Servi S, Specchia G. Role of granulocytes in endothelial injury in coronary heart disease in humans. Atherosclerosis 1991;91:1–14.

  362. 362.

    Riessen R, Isner JM, Blessing E, Loushin C, Nikol S, Wight TN. Regional differences in the distribution of the proteoglycans biglycan and decorin in the extracellular matrix of atherosclerotic and restenotic human coronary arteries. Am J Pathol 1994;144:963–974.

  363. 363.

    Rodman DM. Chronic hypoxia selectively augments rat pulmonary artery Ca2+ and K+ channel-mediated relaxation. Am J Physiol 1992;263:L88–L94.

  364. 364.

    Rose G, Prineas RJ, Mitchell JRA. Myocardial infarction and the intrinsic caliber of the coronary arteries. Br Heart J 1967;29:548–552.

  365. 365.

    Rosenfield K, Isner JM. Intravascular ultrasound in patients undergoing coronary and peripheral arteral revascularization. Intervent Cardiol 1993; 1153–1185.

  366. 366.

    Rosenfield K, Losordo DW, Ramaswamy K. Three dimensional reconstruction of human coronary and peripheral arteries from images recorded during two-dimensional intravascular ultrasound examination. Circulation 1991;84:1938–1956.

  367. 367.

    Rosing DR, Cannon RO, Watson RM. Three year anatomic, functional and clinical follow-up after successful percutaneous transluminal coronary angioplasty. J Am Coll Cardiol 1987;9:1–7.

  368. 368.

    Ross R. The pathogenesis of atherosclerosis—An update. N Engl J Med 1986;8:488–500.

  369. 369.

    Ross R. Growth factors in the pathogenesis of atherosclerosis. Acta Med Scand Suppl 1986;715:33–38.

  370. 370.

    Ross R. The pathogenesis of atherosclerosis: A perspective for the 1990's. Nature 1993;362:801–809.

  371. 371.

    Rubanyi GM, Romero JC, Vanhoutte PM. Flow-induced release of endothelium-derived relaxing factor. Am J Physiol 1986;250:H1145-H1149.

  372. 372.

    Rubin K, Hannson G, Roesnnstrand L, et al. Induction of B-type receptors or platelet-derived growth factors in vascular inflammation: Possible implications for development of vascular proliferation lesions. Lancet 1988;1:1353–1356.

  373. 373.

    Runge MS, Bode C. Inhibition of platelets and thrombin: Implications for treatment of coronary artery thrombosis. Z Kardiol 1993;82(Suppl 2):83–88.

  374. 374.

    Ruoslahti E, Yamaguchi Y. Proteoglycans as modulators of growth factor activities. Cell 1991;64:867–869.

  375. 375.

    Safian RD, Geldfish JS, Erny RE, Schmitt SJ, Schmidt DA, Baim DS. Coronary atherectomy: Clinical, angiographic, and histological findings and observations regarding potential mechanisms. Circulation 1990;82:69–79.

  376. 376.

    Sako Y. Effects of turbulent flow and hypertension on experimental atherosclerosis. JAMA 1962;179:36.

  377. 377.

    Sako Y, Varco RL. Arteriovenous fistula: Results of management of congenital and acquired forms, blood flow measurements, and observations on proximal arterial degenerations. Surgery 1970;67:40.

  378. 378.

    Sanborn TA, Faxon DP, Haudenschild C, Gottsman SB, Ryan TJ. The mechanisms of transluminal angioplasty: Evidence for formation of aneurysms in experimental atherosclerosis. Circulation 1983;68:1136–1140.

  379. 379.

    Sanders M. Angiographic changes thirty minutes following percutaneous transluminal coronary angioplasty. Angiology 1985;36:419–424.

  380. 380.

    Sarembock IJ, La Veau PJ, Sigal SL, Timms ID, Sussman J, Ezekowitz MD. High inflation pressure and an oversized balloon causes the largest increment in the plaque growth following balloon angioplasty (abstr). Circulation 1988;78(Suppl II):II269.

  381. 381.

    Sartore S, Scatena M, Chiavegato A, Faggin E, Giuriato L, Pauletto P. Myosin isoform expression in smooth muscle cells during physiological and pathological vascular remodeling. J Vasc Res 1994;31:61–81.

  382. 382.

    Sarzani R, Brecher P, Chobanian AV. Growth factor expression in the aorta of normotensive and hypertensive rats. J Clin Invest 1989;83:1404–1408.

  383. 383.

    Sato Y, Rifkin DB. Inhibition of endothelial cell movement by pericytes and smooth muscle cells: Activation of a latent transforming growth factor-B like molecule by plasmin during co-culture. J Cell Biol 1989;109:309–315.

  384. 384.

    Sawa H, Fujii S, Sobel BE. Augmented arterial wall expression type-1 plasminogen activator inhibitor induced by thrombosis. Arterioscler Thromb 1992;12:1507–1515.

  385. 385.

    Sawdey M, Podor TJ, Loskutoff DJ. Regulation of type 1 plasminogen activator inhibitor gene expression in cultures of bovine aortic endothelial cells: Induction by transforming growth factor-B, lipopolysaccharide, and tumor necrosis factor-x. J Biol Chem 1989;264:10396–10401.

  386. 386.

    Scalbert E, Levy B, Desche P, Devissaguet M, Safar ME. Vascular effects of perindopril: From experimental to clinical investigation. J Cardiovasc Pharmacol 1991;18(Suppl 7):S25-S32.

  387. 387.

    Schneider MD, Parker TG. Cardiac myocytes as targets for the action of peptide growth factors. Circulation 1990;81:1443–1456.

  388. 388.

    Schwartz L, Bourassa MG, Lesperance J, Aldridge HE, Kazim F, Savatori VA. Aspirin and dipyridamole in the prevention of restenosis after percutaneous transluminal coronary angioplasty. N Engl J Med 1988;318:1714–1719.

  389. 389.

    Schwartz RS, Edwards WD, Antoniades LC, Bailey KR, Holmes DR. Coronary restenosis: Prospects for solution and new prospectives from a porcine model. Mayo Clin Proc 1993;68:54–62.

  390. 390.

    Schwartz RS, Holmes DR, Topol EJ. The restenosis paradigm revisited: An alternative proposal for cellular mechanisms. J Am Coll Cardiol 1992;20:1284–1293.

  391. 391.

    Schwartz RS, Huber KC, Murphy JG, Edwards WD, Camrud AR, Vlietstra RE. Restenosis and the proportional neointimal response to coronary artery injury: Results in a porcine model. J Am Coll Cardiol 1992;19:267–274.

  392. 392.

    Schwartz RS, Koval TM, Edwards WD, Camrud AR, Bailey KR, Browne K, Vlietstra RE, Hohlms DR. Effect of external beam irradiation on neointimal hyperplasia after experimental coronary artery injury. J Am Coll Cardiol 1992;19:1106–1113.

  393. 393.

    Schwartz RS, Murphy JG, Edwards WD, Camrud AR, Vlietstra RE, Holmes DR. Restenosis after balloon angioplasty: A practical proliferative model in porcine coronary arteries (abstr). Circulation 1990;82:2190–2203.

  394. 394.

    Schwartz S, Edwards WD, Murphy JG, Camrud AR, Holmes DR. Restenosis develops in four stages: Serial histologic studies in a coronary injury model (abstr). J Am Coll Cardiol 191;17(Suppl A):52A.

  395. 395.

    Schwartz SM, Campbell GR, Campbell JH. Replication of smooth muscle cells in vascular disease. Circ Res 1986;58:427–444.

  396. 396.

    Schwartz SM, Heimark RL, Majesky MW. Developmental mechanisms underlying pathology of arteries. Physiol Rev 1990;70:1177–1209.

  397. 397.

    Secrest RJ, Chapnick BM. Endothelium-dependent relaxation induced by leukotrienes C4, D4, and E4 in isolated canine arteries. Circ Res 1988;62:983–991.

  398. 398.

    Serruys PW, Luijten HE, Beatt KJ, et al. Incidence of restenosis ater successful coronary angioplasty: A time-related phenomenon. Circulation 1988;77:361–371.

  399. 399.

    Shen J, Luscinskas FW, Connolly A, Dewey CF, Gimbrone MA. Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells. Am J Physiol 1992;262:C384-C390.

  400. 400.

    Shumacker HB. Aneurysm development and degenerative changes in dilated artery proximal to arteriovenous fistula. Surg Gynecol Obstet 1970;130:636.

  401. 401.

    Simonson MS, Dunn MJ. The molecular mechanisms of cardiovascular and renal regulation by endothelin peptides. J Lab Clin Med 1992;119:622–639.

  402. 402.

    Simonson MS, Wang Y, Jones JM, Dunn MJ. Protein kinase C regulates activation of mitogen-activated protein kinase and induction of proto-oncogene c-fos by endothelin-1. J Cardiovasc Pharmacol 1992;20(Suppl 12):S29-S32.

  403. 403.

    Simonton CA, Mark DB, Hinohara T, Tendall DS, Phillips HR, Peter RH. Late restenosis after emergent coronary angioplasty or acute myocardial infarction: Comparison with elective coronary angioplasty. J Am Coll Cardiol 1988;11:698–705.

  404. 404.

    Snow A, Bolender R, Wight TN, Clowes A. Heparin modulates the composition of the extracellular matrix domain surrounding arterial smooth muscle cells. Am J Pathol 1990;137:313–330.

  405. 405.

    Snow RL, Davies P, Pontoppidan H, Zapol WM, Reid L. Pulmonary vascular remodeling in adult respiratory distress syndrome. Am Rev Resp Dis 1982;126:887–892.

  406. 406.

    Spaet T, Stemerman M, Veith F, Lejnieks I. Intimal injury and regrowth in the rabbit aorta: Medial smooth muscle cells as a source of neointima. Circ Res 1974;36:58–70.

  407. 407.

    Stadius ML, o R, Fleischhauer JF, Kernoff R, Billigham M, Gown AM. Time course and cellular characteristics of the iliac artery response to acute balloon injury: An angiographic, morphometric and immunocytochemical analysis in the cholesterol fed New Zealand White rabbit. Arterioscler Thromb 1992;12:1267–1273.

  408. 408.

    Stanley JC, Ernst CB, Fry WJ. Fate of 100 aorto-renal vein grafts: Characteristics of late graft expansion, aneurysmal dilatation and stenosis. Surgery 1973;74:931.

  409. 409.

    Stary HC. The sequence of cell and matrix changes in atherosclerotic lesions of coronary arteries in the first four years of life. Eur Heart J 1190;11(Suppl E):3–19.

  410. 410.

    Stary HC, Blankenhorn DH, Chandler AB, et al. A definition of the intima of human arteries and of its atherosclerosis-prone regions: A report from the committee of vascular lesions of the Council on Arteriosclerosis, American Heart Association. Circulation 1992;85:391–405.

  411. 411.

    Steele PM, Chesebro JH, Stanson AW. Balloon angioplasty: Natural history of the pathophysiological response to injury in a pig model. Circ Res 1985;57:105–112.

  412. 412.

    Stenmark KR, Orton EC, Reeves JT, Voelkel NF, Crouch EC. Vascular remodeling in neonatal pulmonary hypertension. Role of the smooth muscle cell. Chest 1988;93(Suppl):127S-133S.

  413. 413.

    Steuli CH, Schmidhauser C, Kobrin M, Bissell MJ, Derynck R. Extracellular matrix regulates expression of the TGF-B1 gene. J Cell Biol 1993;120:253–260.

  414. 414.

    Stiel GM, Stiel LSG, Schofer J, Donath K, Mathey DG. Impact of compensatory enlargement of atherosclerotic coronary arteries on angiographic assessment of coronary artery disease. Circulation 1989;80:1603–1609.

  415. 415.

    Stiles CD, Pledger WJ, Tucker RW, Martin RG, Scher CD. Regulation of the Balb/c-3T3 cell cycle effects of growth factors. J Supramol Struct 1980;13:489–499.

  416. 416.

    Strauss B, Verkerk A, van Suylen R. Smooth muscle cell culture from human coronary lesions (abstr). Circulation 1990;82(Suppl III):III496.

  417. 417.

    Struyker Boudier HA, van Bortel LM, De Mey JG. Remodeling of the vascular tree in hypertension: Drug effects. Trends Pharmacol Sci 1990;11:240–245.

  418. 418.

    Suga S, Itoh H, Konatsu Y, et al. Cytokine-induced C-type natriuretic peptide (CNP) secretion from vascular endothelial cells—evidence for CNP as a novel autocrine/paracrine regulator from endothelial cells. Endocrinology 1993;133:3038–3041.

  419. 419.

    Suga S, Nakao K, Itoh H, et al. Endothelial production of C-type natriuretic peptide and its marked augmentation by transforming growth factor-beta. Possible existence of “vascular natriuretic peptide system”. J Clin Invest 1992;90:1145–1149.

  420. 420.

    Tada T, Reidy MA. Endothelial regeneration IX. Arterial injury followed by rapid endothelial repair induces smooth muscle cell proliferation but not intimal thickening. Am J Pathol 1987;129:429–433.

  421. 421.

    Taubman MB. Gene induction in vessel wall injury. Thromb Haemost 1993;70:180–183.

  422. 422.

    Taylor RR, Gibbons FA, Cope GD, Cumpston GN, Mews GC, Luke P. Effects of low-dose aspirin on restenosis after coronary angioplasty. Am J Cardiol 1991;68:874–878.

  423. 423.

    Thornton MA, Gruentzig AR, Hollman J, King SB, Douglas JS. Coumadin and aspirin in prevention of recurrence after transluminal coronary angioplasty: A randomized study. Circulation 1984;69:721–727.

  424. 424.

    Tobis JM, Mahon DJ, Goldberg SL, Nakamura S, Colombo A. Lessons from intravascular ultrasonography: Observations during interventional angioplasty procedures. J Clin Ultrasound 1993;21:589–607.

  425. 425.

    Topol EJ. The restenosis “antitheory”. Mayo Clin Proc 1993;68:88–90.

  426. 426.

    Topol EJ, Leya F, Pinkerton CA, et al. A comparison of directional atherectomy with coronary angioplasty in patients with coronary artery disease. N Engl J Med 1993;329:221–227.

  427. 427.

    Towne JB, Quinn K, Salles-Cunha S, Bernahrd VM, Clowry LJ. Effect of increased arterial blood flow on localization and progression of atherosclerosis. Arch Surg 1982;117:1469–1474.

  428. 428.

    Tozzi CA, Poiani GJ, Harangozo AM, Boyd CD, Riley DJ. Pressure-induced connective tissue synthesis in pulmonary artery segments is dependent on intact endothelium. J Clin Invest 1989;84:1005–1012.

  429. 429.

    Tozzi CA, Poiani GJ, Harangozo AM, Boyd CD, Riley DJ. Pressure induced connective tissue synthesis in pulmonary artery segments is dependent on intact endothelium. J Clin Invest 1989;84:1005–1012.

  430. 430.

    Ueda M, Becker AE, Fujimoto T. Pathological changes induced by repeated percutaneous transluminal angioplasty. Br Heart J 1987;58:635–643.

  431. 431.

    Ueda M, Becker AE, Tsukada T, Numano F, Fujimoto T. Fibrocellular tissue response after percutaneous transluminal coronary angioplasty. An immunocytochemical analysis of the cellular composition. Circulation 1991;83:1327–1332.

  432. 432.

    van Erven L, Post MJ, Velema E, Borst C. In the normal rabbit femoral artery increasing arterial wall injury does not lead to increased intimal hyperplasia. J Vasc Res 1994;31:153–162.

  433. 433.

    Vane JR, Anggard EE, Botting RM. Regulatory functions of the vascular endothelium. N Engl J Med 1990;323:27–36.

  434. 434.

    Virmani R, Farb A, Burke AP. Coronary angioplasty from the perspective of atherosclerotic plaque: Morphologic predictors of immediate success and restenosis. Am Heart J 1994;127:163–179.

  435. 435.

    Vlodaver Z, Edwards JE. Pathology or coronary atherosclerosis. Prog Cardiovasc Dis 1971;14:256–274.

  436. 436.

    Vogt M, Motz W, Strauer BE. Ace-inhibitors in coronary artery disease? Basic Res Cardiol 1993;88(Suppl 1):43–64.

  437. 437.

    Von Essen R, Uebis R, Bertram B, Schmitz JH, Seiger K, Efferts S. Influence of balloon size on the recurrence rate of coronary stenosis: Results of a prospective investigation. In: Hofling B, ed. Current Problems in PTCA 1987:89.

  438. 438.

    Walker L, Bowen-Pope D, Ross R, Reidy M. Production of platelet-derived growth factor-like molecules by cultured arterial smooth muscle cells accompanies proliferation after arterial injury. Proc Natl Acad Sci USA 1986;83:7311–7315.

  439. 439.

    Walker LN, Ramsay MM, Bowyer DE. Endothelial healing following defined injury to rabbit aorta: Depth of injury and mode of repair. Atherosclerosis 1983;47:123–130.

  440. 440.

    Waller BF. Crackers, breakers, stretchers, drillers, scrapers, shavers, burners, welders and melters: The future treatment of atherosclerotic coronary artery disease? A clinical-morphologic assessment. J Am Coll Cardiol 1989;13:969–987.

  441. 441.

    Waller BF, McManus BM, Kishel JC. Major epicardial coronary arteries 80 to 150 days after percutaneous transluminal coronary angioplasty: Analysis of three necrospy patients. Am J Cardiol 1982;51:81–84.

  442. 442.

    Wang DH, Prewitt RL. Captopril reduces aortic and microvascular growth in hypertensive and normotensive rats. Hypertension 1990;15:68–77.

  443. 443.

    Wang N, Butler JP, Ingber DE. Mechanotransduction across the cell surface and through the cytoskeleton. Science 1993;260:1124–1127.

  444. 444.

    Watson PA. Function follows form: Generation of intracellular signals by cell deformation. FASEB J 1991;5:2013–2019.

  445. 445.

    Weinstein R, Stemerman M, van der Spek J, Maciag T, Hoover G. Fibronectin dependence for attachment in vitro: Smooth muscle-cell versus fibroblast. Cold Spring Harbor Conferences on Cell Proliferation 1982;9:145–154.

  446. 446.

    Weinstein R, Wenc K. Growth factor responses of human arterial endothelial cells in vitro. In Vitro Cell Dev Biol 1986;22:549–556.

  447. 447.

    White CJ. Angioscopy. In: Topol EJ, ed. Textbook of Interventional Cardiology. 2nd ed. Philadelphia: WB Saunders, in press.

  448. 448.

    White FC, Bloor CM. Coronary vascular remodeling and coronary resistance during chronic ischemia. Am J Cardiovasc Pathol 1992;4:193–202.

  449. 449.

    Wight TN. Cell biology of arterial proteoglycans. Arteriosclerosis 1989;9:1–20.

  450. 450.

    Wight TN, Kinsella MG, Qwarnstrom EE. The role of proteoglycans in cell adhesion, migration and proliferation. Curr Opin Cell Biol 1992;4:793–801.

  451. 451.

    Wilcox JN. Thrombin and other potential mechanisms underlying restenosis. Circulation 1991;84:432–435.

  452. 452.

    Wilcox JN. Analysis of local gene expression in human atherosclerosis plaques by in situ hybridization. Trends Cardiovasc Med 1991;1:17–24.

  453. 453.

    Wilcox JN. Molecular biology: Insight into the causes and prevention of restenosis after arterial intervention. Am J Cardiol 1993;72:88E-95E.

  454. 454.

    Wilens SL, Plair CM, Henderson D. Size of the major epicardial coronary arteries at necropsy. JAMA 1966;198:1325–1329.

  455. 455.

    Wilsons J, Adams CWM, Brander WL. The antiocclusive effect of coronary dilatation with age. Atherosclerosis 1978;29:503–507.

  456. 456.

    Winokur RS, Casscells W, Roberts A, Sporn MB. Expression of transforming growth factors B1, 2 and 3 following vascular injury (abstr). J Cell Biochem Suppl 1991;15C:G414.

  457. 457.

    Winter RJ, Zhao L, Krausz T, Hughes JM. Neutral endopeptidase 24:11 inhibition reduces pulmonary vascular remodeling in rats exposed to chronic hypoxia. Am Rev Resp Dis 1995;144:1342–1346.

  458. 458.

    Zairns CK, Glagov S, Vesselinovitch D, Wissler RW. Aneurysm formation in experimental atherosclerosis: Relationship to plaque evolution. J Vasc Surg 1990;12:246–256.

  459. 459.

    Zarins C, Zatina MA, Giddens DP, Ku DN, Glagov S. Shear stress regulation of artery lumen diameter in experimental atherogensis. J Vasc Surg 1987;5:413–420.

  460. 460.

    Zarins CK, Bomberger RA, Glagov S. Local effects of stenosis: Increased flow velocity inhibits atherogenesis. Circulation 1981;64(Suppl 2):221–227.

  461. 461.

    Zarins CK, Giddens DP, Bharadvaj BK, Sottiurai VS, Mabon RF, Glagov S. Carotid bifrucation atherosclerosis: Quantitative correlation of plaque localization with flow velocity profiles and wall shear stress. Circ Res 1983;53:502–514.

  462. 462.

    Zarins CK, Weisenberg E, Kolettis G, Stankunavicius R, Glagov S. Differential enlargement of arterial segments in response to enlarging atherosclerotic plaques. J Vasc Surg 1988;7:386–394.

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Correspondence to Douglas W. Losordo M.D..

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Bortman, S.M., Losordo, D.W. Dynamics of vascular remodeling: An overview and bibliography. J Thromb Thrombol 3, 71–86 (1996). https://doi.org/10.1007/BF00226415

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Key words

  • remodeling
  • restenosis