The juxtaglomerular apparatus (JGA) in the rabbit kidney was examined by transmission electron microscopy and by freeze fracturing. It was found, that the Goormaghtigh cells of the JGA are extensively coupled with the mesangial cells within the glomerular tuft by gap junctions. A broad band of gap junctions starting within the Goormaghtigh cells, traversing the transitional area at the root of the glomerular tuft and continuing along the mesangial cells has been revealed by freeze fracturing. No gap Junctional connections to the macula densa cells have been found. In accordance with data from literature it may be stated that all smooth muscle derived cell groups at the vascular pole of the glomerulus (smooth muscle cells of the vas afferens and efferens, granular cells, Goormaghtigh cells, mesangial cells) are extensively coupled by gap junctions with each other. It is supposed that this cell system may act as a synchronized functional unit.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Barajas, L.: The ultrastructure of the juxtaglomerular apparatus as disclosed by three-dimensional reconstructions from serial sections. The anatomical relationship between the tubular and vascular components. J. Ultrastruct. Res. 33, 116–146 (1970)
Boll, H.U., Forssmann, W.G., Taugner, R.: Studies on the juxtaglomerular apparatus. IV. Freeze-fracturing of membrane surfaces. Cell Tiss. Res. 161, 459–469 (1975)
Branton, D., Bullivant, S., Gilula, N.B., Karnovsky, M.J., Moor, H., Mühlethaler, K., Northcote, D.H., Packer, L., Satir, B., Satir, P., Speth, V., Staehlin, L.A., Steere, K.L., Weinstein, K.S.: Freeze-etching nomenclature. Science 190, 54–56 (1975)
Bucher, O., Kaissling, B.: Morphologie des juxtaglomerulären Apparates. Verh. anat. Ges. 67, 109–136 (1973)
Forssmann, W.G., Taugner, R.: Studies on the juxtaglomerular apparatus. V. The juxtaglomerular apparatus in Tupaia with special reference to intercellular contacts. Cell Tiss. Res. 177, 291–305 (1977)
Hornych, H., Richet, G.: Dissociated effect of sodium intake on glomerular and presser responses to angiotensin. Kidney Int, 11, 28–34 (1977)
Luft, I.H.: Improvements in epoxy resin embedding methods. J. biophys. biochem. Cytol. 9, 409–414 (1961)
McNutt, N.S., Weinstein, R.S.: Membrane ultrastructure at mammalian intercellular junctions. Progr. Biophys. molec. Biol. 26, 45–101 (1973)
Oberling, C., Halt, P.Y.: Etude, de l'appareil juxtaglomérulaire du rat au microscope électronique. Ann. Anat. path. 5, 441–474 (1960)
Pricam, C., Humbert, F., Perrelet, A., Orci, L.: Gap junctions in mesangial and lacis cells. J. Cell Biol. 63, 349–354 (1974)
Schnermann, J., Ploth, D.W., Hermle, M.: Activation of tubulo-glomerular feedback by chloride transport. Pflügers Arch. ges. Physiol. 362, 229–240 (1976)
Thurau, K., Mason, I.: The intrarenal function of the juxtaglomerular apparatus, in kidney and urinary tract physiology, edit. by Thurau, K., London: Butterworth 1974, MTP, Int. Rev. of Science, Ser. 1, Vol. 6, pp. 357–389
Tobian, L., Tomboulan, A., Janacek, J.: The effect of high perfusion pressure on the granulation of juxta-glomerular cells in an isolated kidney. J. clin. Invest. 38, 605–610 (1959)
About this article
Cite this article
Taugner, R., Schiller, A., Kaissling, B. et al. Gap junctional coupling between the JGA and the glomerular tuft. Cell Tissue Res. 186, 279–285 (1978). https://doi.org/10.1007/BF00225537
- Kidney (rabbit)
- Juxtaglomerular apparatus
- Mesangial cells
- Gap junctions
- Electron microscopy, freeze fracturing