The influence of purebred selection on the combining abilities of five lines of mice was examined. Two replicated testcross diallels were made after 10 and 20 generations of purebred selection for litter size, weaning weight, weight gain, and feed efficiency. Average direct genetic effects were of major importance, followed by average maternal genetic effects. In all of the replications, between two and four out of ten crosses showed significant heterosis. Heterosis ranged from 0 to 38% in litter size, from 0 to 20% in weaning weight, from -11 to 11% in weight gain, and from -8 to 17% in feed efficiency. For litter size and weaning weight, heterosis estimates increased between 80 and 100% from generation 10 to 20. Weight gain and feed efficiency showed decreasing heterosis with partly negative estimates in the second diallel. Combinations exhibiting significant heterosis varied between replicates and between the two diallels.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Aumann J (1986) Modellversuch mit Mäusen zur Schätzung von Kreuzungswirkungen unter Berücksichtigung der Epistasie. PhD, University of Munich, Germany
Bakker H, Nagai J, Eisen EJ (1976) Average genetic and heterotic effects on growth in mice selected for large 6-week body weight or rapid postweaning gain. J Anim Sci 43:1145–1155
Bell AE, Moore CH, Warren DC (1955) The evaluation of new methods for the improvement of quantitative characteristics. Cold Spring Harbor Symp Quant Biol 20:197–212
Casas DE, Wellhausen ET (1968) Diveridad genetica y heterosis. Cited in: Eisen et al. (1983)
tEisen EJ, Hörstgen-Schwark G, Saxton AM, Bandy TR (1983) Genetic interpretation and analysis of diallel crosses with animals. Theor Appl Genet 65:17–23
Eisen EJ, Hörstgen-Schwark G, Bandy TR, Saxton AM (1984) Postpartum performance in a diallel cross among lines of mice selected for litter size and body weight. J Anim Sci 58:863–877
Gardner CO, Eberhart SA (1966) Analysis and interpretation of the variety cross diallel and related populations. Biometrics 22:439–451
Griffing B (1956) Concept of general and specific combining ability in relation ot diallel crossing systems. Aust J Biol Sci 9:463–493
Harvey WR (1975) Least squares analysis of data with unequal subclass numbers. USDA-ARS, H-4
Henderson CR (1948) Estimation of general, specific, and maternal abilities in crosses among inbred lines of swine. PhD thesis, Iowa State University, Ames/IA (Cited in: Harvey 1975)
Henderson CR (1977) Prediction of the merits of single crosses. Theor Appl Genet 49:273–282
Hörstgen G (1978) Modellversuch mit Mäusen zur genetischen Differenzierung von Zuchtlinien durch Selektion für quantitative Merkmale. PhD thesis, University of Göttingen, Germany
Hörstgen-Schwark G, Eisen EJ, Saxton AM, Bandy TR (1984a) Diallel cross among lines of mice selected for litter size and body weight: growth traits. J Anim Breed Genet 101:96–111
Hörstgen-Schwark G, Eisen EJ, Saxton AM, Bandy TR (1984b) Reproductive performance in a diallel cross among lines of mice selected for litter size and body weight. J Anim Sci 58:846–862
Komender P (1987) Auswertung von diallelen Kreuzungsversuchen zur Schätzung von Kreuzungsparametern ergänzt durch ein Beispiel aus der Schweinezucht. PhD thesis, University of Hohenheim, Germany
Komender P (1988) Crossbreeding in farm animals. III. A general method of comparing models to estimate crossbreeding parameters with an application to diallel crossbreeding experiments. J Anim Breed Genet 105:362–371
Komnender P, Fewson D (1987) Estimation of crossbreeding parameters in a full-diallel experiment with selected lines of swine. In: Proc 38th Ann Meeting EAAP, Lisbon, pp I:218–219
van den Nieuwenhuizen J, Bakker H, Buis RC (1982) Genetic differences in reproduction and growth rate between two lines of mice selected for litter size. J Anim Breed Genet 99:292–307
Communicated by E. J. Eisen
About this article
Cite this article
Götz, K.-., Glodek, P. & Rapp, K. Crossbreeding effects after long-term selection for purebred performance: a model experiment with mice. Theoret. Appl. Genetics 81, 720–728 (1991). https://doi.org/10.1007/BF00224980
- Diallel cross
- Maternal effects