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The origin and ultrastructural characteristics of corticotropin-releasing factor (CRF)-immunoreactive nerve fibers in the posterior pituitary of the rat

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A fine network of corticotropin-releasing factor (CRF)-immunopositive fibers was found in the posterior lobe of the pituitary of the rat. The intermediate and distal lobes were free of CRF-immunoreactivity. Varicose, terminal-like axons were frequently observed around capillary vessels. Surgical isolation of the paraventricular nuclei resulted in a complete disappearance of CRF-immunoreactive fibers from the posterior lobe. CRF-immunopositive fibers show the general characteristics of peptidergic axons. These ultrastructural observations support the idea that CRF is secreted into capillary vessels.

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Correspondence to István Lengvári M.D..

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Lengvári, I., Liposits, Z., Vigh, S. et al. The origin and ultrastructural characteristics of corticotropin-releasing factor (CRF)-immunoreactive nerve fibers in the posterior pituitary of the rat. Cell Tissue Res. 240, 467–471 (1985). https://doi.org/10.1007/BF00222361

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Key words

  • CRF immunohistology
  • Paraventricular nuclei
  • Pituitary gland, pars nervosa
  • Electron microscopy
  • Rat