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Effects of d-propranolol and estradiol on the cervicovaginal epithelium

Correlation with adenylate cyclase activity


The cervicovaginal epithelium of neonatal mice produces a material with specific antigenic properties (CVA) and this material is produced in increased amounts after estradiol treatment. Using a cytochemical method, estradiol treatment was shown to result in an increase of adenylate cyclase activity in the same epithelium.

When d-propranolol is injected together with estradiol, the increase in CVA is inhibited, while the hormone-induced proliferation of epithelial cells is not influenced. When adenylate cyclase activity is studied under identical conditions, the estradiol-promoted increase in enzyme activity is largely counteracted by d-propranolol. These findings would suggest that Adenosine 3′5′-cyclic monophosphate (cAMP) has a role in some, but not all, estradiol-mediated effects in the neonatal cervicovaginal epithelium.

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Correspondence to Dr. Stener Kvinnsland.

Additional information

This work was supported by grants from the Norwegian Research Council for Science and the Humanities and from the Norwegian Cancer Society (Landsforeningen mot Kreft)

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Kvinnsland, S. Effects of d-propranolol and estradiol on the cervicovaginal epithelium. Cell Tissue Res. 173, 325–334 (1976).

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Key words

  • Cervical epithelium
  • Mouse
  • d-propranolol
  • Estradiol
  • Adenylate cyclase activity
  • Adenosine 3′5′-cyclic monophosphate