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Ultrastructural analysis of the human cerebral ventricular system

III. The choroid plexus

Summary

The ultrastructural organization of the human fetal choroid plexus was assessed with scanning electron microscopy. The membranous modifications of choroidal ependymal cells differ remarkably between 11 and 20 weeks of intrauterine development and suggest a variable functional capacity at different times of ontogenesis. Based upon existing data coupled with the ultra-architectural organization of cilia, clavate and linear microvilli are seen with scanning electron microscopy, a multiple functional role is hypothesized for choroidal ependymal cells.

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References

  1. Allan, D. J., Low, F. N.: The ependymal surface of the dog as revealed by scanning electron microscopy. Amer. J. Anat. 137, 483–489 (1974)

  2. Brightman, M. W., Reese, T. S.: Junctions between intimately apposed cell membranes in the vertebrate brain. J. Cell Biol. 40, 648–677 (1969)

  3. Bruni, J. E., Montemurro D. G. Clattenburg, R. E., Sing, R. P.: A scanning electron microscopic study of the ependymal surface of the third ventricle of the rabbit, rat, mouse and human brain. Anat. Rec. 174, 407–419 (1972)

  4. Cathcart, R. S., Worthington, W. C.: Ciliary movement in the rat cerebral ventricles: Clearing action and direction of currents. J. Neuropath. exp. Neurol. 23, 609–618 (1964)

  5. Coates, P.: Supraependymal cells in the recess of the monkey third ventricle. Amer. J. Anat. 136, 353–359 (1973)

  6. Cserr, H. F.: Physiology of the choroid plexus. Physiol. Rev. 51, 273–311 (1971)

  7. Cserr, H. F., Van Dyke, D. H.: 5-Hydroxyindulacetic acid accumulation by isolated choroid plexus. Amer. J. Physiol. 220, 718–723 (1971)

  8. Hassin, G. B.: The cerebrospinal fluid. Its origin, nature and function. J. Neuropath. 7, 172–181 (1948)

  9. Heisey, S. R., Held, D., Pappenheimer, J. R.: Bulk flow and diffusion in the cerebrospinal fluid system of the goat. Amer. J. Physiol. 203, 775–781 (1962)

  10. Joseph, S. A., Scott, D. E., Vaala, S. S., Knigge, K. M., Krobisch-Dudley, G.: Localization and content of thyrotrophin releasing factor (TRF) in median eminence of hypothalamus. Acta endocr. 74, 215–225 (1973)

  11. Karnovsky, M. J.: A formaldehyde-glutaraldehyde fixative of high osmoality for use in electron microscopy. J. Cell Biol. 27, 137 A (1965)

  12. Knigge, K. M., Scott, D. E.: Structure and function of the median eminence. Amer. J. Anat. 129, 223–244 (1970)

  13. Knowles, F., Anand Kumar, T. C.: Structural changes related to reproduction in the hypothalamus. Part II. The Pars tuberalis. Phil. Trans. B. 256, 357–375 (1969)

  14. Kobayashi, H., Wada, M., Uemura, H.: Uptake of peroxidase from the third ventricle by ependymal cells of the median eminence. Z. Zellforsch. 127, 545–551 (1972)

  15. Kozlowski, G. P.: (Personal communication, 1972)

  16. Leonhardt, H., Lindemann, B.: Surface morphology of the subfornical organ in the rabbit's brain. Z. Zellforsch. 146, 243–260 (1973)

  17. Leonhardt, H., Lindner, E.: Marklose Nervenfasern im III und IV Ventrikel des Kaninchen-und Katzengehirns. Z. Zellforsch. 78, 1–18 (1967)

  18. Lumsden, C. E.: Observations on the choroid plexus maintained as an organ in tissue culture. Ciba Found. Symp. Cerebrospinal Fluid. 97–123 (1958)

  19. Maxwell, D. S., Pease, D. C.: The electron microscopy of the choroid plexus. J. Biophys. Biochem. 2, 467–474 (1956)

  20. Milhorat, T. H.: Choroid plexus and cerebrospinal fluid production. Science 166, 1514–1516 (1969)

  21. Milhorat, T. H.: Hammock, M. R., Fenstermacher, J. D., Levin, V. A.: Cerebrospinal fluid production by the choroid plexus and brain. Science 173, 330–332 (1971)

  22. Millhouse, O. E.: Light and electron microscopic studies of the third ventricular wall. Z. Zellforsch. 127, 149–174 (1972)

  23. Schecter, J., Weiner, R.: Ultrastructural changes in the ependymal lining of the median eminence following intraventricular administration of catecholamine. Anat. Rec. 172, 643–650 (1972)

  24. Scott, D. E., Kozlowski, G. P., Krobisch-Dudley, G.: A comparative ultrastructural analysis of the third cerebral ventricle of the North American mink Mustela vison. Anat. Rec. 175, 159–168 (1973)

  25. Scott, D. E., Kozlowski, G. P., Paull, W. K., Ramalingam, S., Krobisch-Dudley, G.: Scanning electron microscopy of the human cerebral ventricular system. II. The fourth ventricle. Z. Zellforsch. 139, 61–68 (1973)

  26. Scott, D. E., Kozlowski, G. P., Sheridan, M. N.: Scanning electron microscopy in the ultrastructural analysis of the mammalian cerebral ventricular system. Int. Rev. Cytol. 37, 349–388 (1974)

  27. Scott, D. E., Krobisch-Dudley, G., Gibbs, F. P., Brown, G. M.: The mammalian median eminence, a comparative and experimental model, p. 35–49. In: Brain-endocrine interactions. Median eminence: structure and function. Int. Symp., Munich, 1971, K. M. Knigge, D. E. Scott and A. Weindl, eds. Basel: Karger 1972

  28. Scott, D. E., Paull, W. K., Kozlowski, G. P., Krobisch-Dudley, G., Knigge, K. M.: The cellular localization of thyrotropic releasing factor (TRF) in the mammalian hypothalamus. Proc. VI Int. Symp. Neurosecretion (in press, 1974)

  29. Scott, D. E., Paull, W. K., Krobisch-Dudley, G.: A comparative scanning electron microscopic analysis of the human cerebral ventricular system. I. The third ventricle. Z. Zellforsch. 132, 203–215 (1972)

  30. Torack, R. M., Finke, E. H.: Evidence for a sequestration of function within the area postrema based on scanning electron microscopy and the penetration of horseradish peroxidase. Z. Zellforsch. 118, 85–96 (1971)

  31. Vigh, B., Aros, B., Wenger, T., Koritsanszky S., Cegledgi, G.: Ependymosecretion (ependymal neurosecretion). IV. The Gomori-positive secretion of the hypothalamic ependyma of various vertebrates and its relation to the anterior pituitary. Acta biol. Acad. Sci. hung. 13, 407–419 (1963)

  32. Vigh-Teichmann, I., Vigh, B.: Structure and function of liquorcontacting neurosecretory systems p. 329–338. In: Aspects of neuroendocrinology, W. Bargmann, B. Scharrer, eds. Berlin-Heidelberg-New York: Springer 1970

  33. Weindl, A., Joynt. R. J.: The median eminence as a circumventricular organ. P. 280–297. In: Brain-endocrine interaction. Median eminence: Structure and function. Int. Symp., Munich, 1971, K. M. Knigge, D. E. Scott and A. Weindl, eds. Basel: Karger 1972

  34. Welch, K.: The secretion of cerebrospinal fluid by Lamina epithelialis. Monogr. surg. Sci., 4, 155–192 1967

  35. Westergaard, E.: The lateral cerebral ventricles and the ventricular walls. An anatomical, histological and electron microscopic investigation on mice, rats, hamsters, guinea pigs and rabbits. Thesis Andelsbogtrykkeriet; Odense. 1–216 (1970)

  36. Wislocki, G. B., Ladman, A. J.: The fine structure of the mammalian choroid plexus, p. 55–75. In: Ciba Foundation Symposium on Cerebrospinal Fluid, G. Wolstenholme and C. O'Connor (eds.), Boston: Little Brown & Co., N.Y. 1958

  37. Worthington, R. S., Cathcart, W. C.: Ependymal cilia: Distribution and activity in the adult human brain. Science 139, 221–222 (1963)

  38. Zimmerman, E. A.: (Personal communication, 1974)

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supported by USPH grant NS 08171.

career development awardee K04 GM 70001

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Scott, D.E., Van Dyke, D.H., Paull, W.K. et al. Ultrastructural analysis of the human cerebral ventricular system. Cell Tissue Res. 150, 389–397 (1974). https://doi.org/10.1007/BF00220145

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Key words

  • Choroid plexus
  • Human fetus
  • Modifications during development
  • Scanning electron microscopy