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Adrenergic innervation of the mouse heart revealed at an early stage using α-methylnoradrenaline

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Summary

The development of noradrenergic innervation was studied in the mouse heart using fluorescence histochemistry. Following incubation of hearts with α-methylnoradrenaline fluorescent nerve fibres were seen as early as 13 days in utero. It is suggested that the neuronal uptake mechanism for noradrenaline is functional at an early stage.

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References

  1. Atwood, G.F., Kirshner, N.: Postnatal development of catecholamine uptake and storage of the newborn rat heart. Develop. Biol. 49, 532–538 (1976)

  2. De Champlain, J., Olson, L., Malmfors, T., Sachs, C.: Fluorescent morphology of developing peripheral adrenergic nerves in the rat. Acta physiol. scand. 80, 276–288 (1970)

  3. Falck, B., Hillarp, N.A., Thieme, G., Torp, A.: Fluorescence of catecholamines and related compounds condensed with formaldehyde. J. Histochem. Cytochem. 10, 348–354 (1962)

  4. Friedman, W.F., Pool, P.E., Jacobitz, D., Seagren, S.C. Braunwald, E.: Sympathetic innervation of the developing rabbit heart. Circulation Res. 23, 25–32 (1968)

  5. Gomez, H.: The development of the innervation of the heart in the rat embryo. Anat. Rec. 130, 53–71 (1958)

  6. Hoar, R.M., Hall, J.L.: The early pattern of cardiac innervation in the foetal guinea-pig. Amer. J. Anat. 128, 499–508 (1970)

  7. Iversen, L.L.: The uptake and storage of noradrenaline in sympathetic nerves. Cambridge: Cambridge University Press 1967

  8. Iversen, L.L., De Champlain, J., Glowinski, J., Axelrod, J.: Uptake, storage and metabolism of norepinephrine in tissues of the developing rat. J. Pharmacol. exp. Ther. 157, 509–516 (1967)

  9. Owman, C., Sjöberg, N.-O., Swedin, G.: Histochemical and chemical studies on pre and post-natal development of the different systems of ‘short’ and ‘long’ adrenergic neurons in peripheral organs of the rat. Z. Zellforsch. 116, 319–341 (1971)

  10. Read, J.B., Burnstock, G.: A method for the localisation of adrenergic nerves during early development. Histochemie 20, 197–200 (1969)

  11. Sachs, C., De Champlain, J., Malmfors, T., Olson, L.: The postnatal development of noradrenaline uptake in the adrenergic nerves of different tissues from the rat. Europ. J. Pharmacol. 9, 67–79 (1970)

  12. Tschernjachiwsky, A.: Note sur le développement du système nerveux du coeur, la terminaison du nerf depresseur et l'innervation du sinus carotidien. Trav. lab. rech. biol. Univ. Madrid 26, 75–98 (1928)

  13. Winckler, J.:Über die adrenergen Herznerven bei Ratte und Meerschweinchen. Entwicklung und Innervationsmuster. Z. Zellforsch. 98, 106–121 (1969)

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Correspondence to Dr. N. B. Standen.

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Mackenzie, E., Standen, N.B. Adrenergic innervation of the mouse heart revealed at an early stage using α-methylnoradrenaline. Cell Tissue Res. 173, 129–132 (1976). https://doi.org/10.1007/BF00219270

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Key words

  • Adrenergic innervation
  • Noradrenaline uptake
  • α-Methylnoradrenaline