Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Septal afferents to the area dentata terminate on vasoactive intestinal polypeptide (VIP)-like immunoreactive, non-pyramidal neurons

An electron-microscopic immunocytochemical degeneration study in the rat

  • 18 Accesses

  • 11 Citations

Summary

Thermic lesions in the medial septum of adult rats result in dark degeneration of terminal boutons in the stratum moleculare and hilus of the area dentata. While most of the degenerating terminals are in synaptic contact with non-reactive cells, part of them end on dendrites of VIP-like immunoreactive neurons.

This is a preview of subscription content, log in to check access.

References

  1. Amaral DG (1978) A Golgi study of cell types in the hilar region of the hippocampus in the rat. J Comp Neurol 182:851–914

  2. Ashwood TJ, Lancaster B, Wheal HV (1984) In vivo and in vitro studies on putative interneurones in the rat hippocampus: possible mediators of feed-forward inhibition. Brain Res 293:279–291

  3. Baisden RH, Woodruff ML, Hoover DB (1984) Cholinergic and non-cholinergic septo-hippocampal projections: a double-label horseradish peroxidase-acetylcholinesterase study in the rabbit. Brain Res 290:146–151

  4. Ben-Ari Y, Krnjevic K, Reinhardt W, Ropert N (1981) Intracellular observation on the disinhibitory action of acetylcholine in the hippocampus. Neuroscience 6:2475–2484

  5. Blackstad TW (1963) Ultrastructural studies on the hippocampal region. In: W Bargmann, JP Schadé, Eds. The rhinencephalon and related structures. Progr Brain Res 3:122–148

  6. Buzsáki G, Eidelberg E (1982) Direct afferent excitation and longterm potentiation of hippocampal interneurons. J Neurophysiol 48:597–607

  7. Chandler JP, Crutcher KA (1983) The septohippocampal projection in the rat: an electron microscopic horseradish peroxidase study. Neuroscience 10:685–696

  8. Eccles JC (1964) The physiology of synapses. Springer, Berlin

  9. Gall C (1984) The distribution of cholecystokinin-like immunoreactivity in the hippocampal formation of the guinea pig: localization in the mossy fibers. Brain Res 306:73–83

  10. Goldschmidt RB, Steward O (1980) Preferential neurotoxicity of colchicine for granule cells of the dentate gyrus of the adult rat. Proc Nat Acad Sci USA 77:3047–3051

  11. Harris KM, Marshall PE, Landis DMD (1985) Ultrastructural study of cholecystokinin-immunoreactive cells and processes in area CA1 of the rat hippocampus. J Comp Neurol 233:147–158

  12. Hökfelt T, Dahlström A (1971) Effects of two mitosis inhibitors (colchicine and vinblastine) on the distribution and axonal transport of noradrenaline storage particles studied by fluorescence and electron microscope. Z Zellforsch 119:460–482

  13. Hsu S-M, Raine L, Fanger H (1981) Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabelled antibody (PAP) procedures. J Histochem Cytochem 29:577–580

  14. Ibata Y, Desiraju T, Pappas GD (1971) Light and electron microscopic study of the projection of the medial septal nucleus to the hippocampus of the cat. Exp Neurol 33:103–122

  15. Köhler C (1983) A morphological analysis of vasoactive intestinal polypeptide (VIP)-like immunoreactive neurons in the area dentata of the rat brain. J Comp Neurol 221:247–262

  16. Köhler C, Chan-Palay V, Wu J-Y (1984) Septal neurons containing glutamic acid decarboxylase immunoreactivity project to the hippocampal region in the rat brain. Anat Embryol 169:41–44

  17. Léránth C, Frotscher M (1983) Commissural afferents to the rat hippocampus terminate on vasoactive intestinal polypeptide-like immunoreactive non-pyramidal neurons. An EM immunocytochemical degeneration study. Brain Res 276:357–361

  18. Léránth CS, Frotscher M, Tömböl T, Palkovits M (1984) Ultrastructure and synaptic connections of vasoactive intestinal polypeptide-like immunoreactive non-pyramidal neurons and axon terminals in the rat hippocampus. Neuroscience 12:531–542

  19. Mosko S, Lynch G, Cotman CW (1973) The distribution of septal projections to the hippocampus of the rat. J Comp Neurol 152:163–174

  20. Pickel V (1981) Immunocytochemical methods. In: L Heimer, MJ Robards (Eds). Neuroanatomical tract-tracing methods. Plenum, New York

  21. Ribak CE, Anderson L (1980) Ultrastructure of the pyramidal basket cells in the dentate gyrus of the rat. J Comp Neurol 192:903–916

  22. Ribak CE, Vaughn JE, Saito K (1978) Immunocytochemical localization of glutamic acid decarboxylase in neuronal somata following colchicine inhibition of axonal transport. Brain Res 140:315–332

  23. Rovira C, Ben-Ari Y, Cherubini E (1983) Dual cholinergic modulation of hippocampal somatic and dendritic field potentials by the septo-hippocampal pathway. Exp Brain Res 49:151–155

  24. Shute CCD, Lewis PR (1963) Cholinesterase-containing systems of the brain of the rat. Nature 199:1160–1164

  25. Stengaard-Pedersen K, Fredens K, Larsson L-I (1981) Enkephalin and zinc in the hippocampal mossy fiber system. Brain Res 212:230–233

  26. Storm-Mathisen J (1970) Quantitative histochemistry of acetylcholinesterase in rat hippocampal region correlated to histochemical staining. J Neurochem 17:739–750

  27. Swanson LW, Teyler TJ, Thompson RF (1982) Hippocampal long-term potentiation: mechanisms and implications for memory. Neurosci Res Prog Bull 20

Download references

Author information

Correspondence to Priv.-Doz. Dr. Walter K. Schwerdtfeger.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Schwerdtfeger, W.K. Septal afferents to the area dentata terminate on vasoactive intestinal polypeptide (VIP)-like immunoreactive, non-pyramidal neurons. Cell Tissue Res. 244, 235–238 (1986). https://doi.org/10.1007/BF00218404

Download citation

Key words

  • Hippocampus
  • Area dentata
  • Vasoactive intestinal polypeptide (VIP)
  • Interneurons
  • Rat