The liver of the adult cod (teleost, Gadus morhua macrocephalus) was observed with transmission and scanning electron microscopy. Hepatocytes of this animal are extremely large (about 50–70 μm in diameter) and characterized by numerous large lipid droplets (5–15 μm in diameter) showing fluorescence for vitamin A, though weaker than that of Ito cells. No Kupffer cells were recognized in the endothelial lining. Collagen fibrils are sparse in the perisinusoidal space, while Ito cells stretching their long cytoplasmic processes to the perisinusoidal as well as interparenchymatous spaces are frequent. There are a number of large desmosomes between the cytoplasmic processes, and all Ito cells seem to be interconnected by these junctions. The cytoplasm in the cell bodies and cell processes is occupied by bundles of intermediate filaments, while organelles are poorly developed. Small vesicles and caveolae are arranged along the plasma membrane. Scanning electron microscopy shows distinct three-dimensional networks consisting of Ito cells and their processes, which might be supporting elements of the liver tissue. We wish to emphasize the concept of this hepatoskeletal system.
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Fujita, H., Tatsumi, H., Ban, T. et al. Fine-structural characteristics of the liver of the cod (Gadus morhua macrocephalus), with special regard to the concept of a hepatoskeletal system formed by Ito cells. Cell Tissue Res. 244, 63–67 (1986). https://doi.org/10.1007/BF00218382
- Cod liver
- Ito cell