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HLA class I nucleotide sequences, 1991


The HLA class I sequences included in this compilation are taken from publications listed in the accompanying paper, Nomenclature for factors of the HLA system, 1990 (Bodmer et al. 1991) and Nomeclature for factors of the HLA system, 1989 (Bodmer et al. 1990). Where discrepancies have arisen between reported sequences the original authors have been contavted where possible, and necessary amendments to published sequences have been incorporated into this alignment. Future sequencing may identify errors in this list and we would welcome any evidence that helps to maintain the accuracy of this compilation. In the sequence alignments identify between residues is indicated by a hyphen (-). Unavailable sequence is indicated by a period (.). Gaps in the sequence are inserted to maintain the alignment between different alleles showing variation in amino acid number.

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  1. Bodmer, J. G., Marsh, S. G. E., Albert, E. D., Bodmer, W. F., Dupont, B., Erlich, H. A., Mach, B., Mayr, W. R., Parham, P., Sasasuki, T., Schreder, G. M. Th., Strominger, J. L., Svejgaard, A., and Terasaki, P. I.: Nomenclature for factors of the HLA system, 1990. Immunogenetics 33: this issue, 1991

  2. Bodmer, J. G., Marsh, S. G. E., Parham, P., Erlich, H. A., Albert, E. D., Bodmer, W. F., Dupont, B., Mach, B., Mayr, W. R., Sasasuki, T., Schreder, G. M. Th., Strominger, J. L., Svejgaard, A., and Terasaki, P. I. Nomenclature for factors of the HLA system, 1989. Immunogenetics 31: 131–140, 1990

  3. Ohya, K., Kondo, K., and Mizuno, S.: Polymorphism in the human class I MHC locus HLA-E in Japanese. Immunogenetics 32: 205–209, 1990

  4. Okada, K., Prentice, H. L., Boss, J. M., Levy, D. J., Kappes, D., Spies, T., Raghupathy, R., Mengler, R. A., Auffray, C., and Strominger, J. L.: SB subregion of the major histocompatibility complex: gene organization, allelic polymorphism and expression in transformed cells. EMBO J 4: 739–748, 1985

  5. Parham, P., Lomen, C. E., Lawlor, D. A., Ways, J. P., Holmes, N., Coppin, H. L., Salter, R. D., Wan, A. M., and Ennnis, P. D.: Nature of polymorphism in HLA-A,-B, and-C molecules. Proc Natl Acad Sci USA 85: 4005–4009, 1988

  6. Petersdorf, E. W., Griffith, R. L., Erlich, H. A., Mickelson, E. M., Smith, A. G., Nisperos, B. B., Martin, P. J., and Hansen, J. A.: Unique sequences for two HLA-DRBI genes expressed on distinct DRw6 haplotypes. Immunogenetics 32: 96–103, 1990

  7. Petersdorf, E. W., Smith, A. G., Mickelson, E. M., Martin, P. J., and Hansen, J. A.: Ten HLA-DR4 alleles defined by sequence polymorphisms within the DRBI first domain. (1991) Immunogenetics 33: 267–275, 1991

  8. Scharf, S. J., Freidmann, A., Steinman, L., Brautbar, C., and Erlich, H. A.: Specific HLA-DQB and HLA-DRBI alleles confer susceptibility to pemphigus vulgaris. Proc Natl Acad Sci USA 86: 6215–6219, 1989

  9. Schenning, L., Larhammar, D., Bill, P., Wiman, K., Jonsson, A.-K., Rask, L., and Peterson, P. A.: Both α and β chains of HLA-DC class II histocompatibility antigens display extensive polymorphism in their amino-terminal domains. EMBO J 3: 447–452, 1984

  10. Sekimata, M., Hiraiwa, M., Andrien, M., Dupont, E., Karaki, S., Yamamoto, J., Kano, K., and Takiguchi, M.: Allodeterminants and evolution of a novel HLA-B5 CREG antigen HLA-B SNA. J Immunol 144: 3228–3233, 1990

  11. Srivastava, R., Duceman, B. W., Biro, P. A., Sood, A. K., and Weissman, S. M.: Molecular organisation of the class I genes of human major histocompatibility complex. Immunol Rev 84: 93–121, 1985

  12. Takiguchi, M., Nishimura, I., Hayashi, H., Karaki, S., Kariyone, A., and Kano, K.: The structure and expression of genes encoding serologically undetected HLA-C locus antigens. J Immunol 143: 1372–1378, 1989

  13. Tonelle, C., DeMars, R., and Long, E. O.: DOβ: a new β chain gene in HLA-D with a distinct regulation of expression. EMBO J 4: 2839–2847, 1985

  14. Watanabe, Y., Tokunaga, K., Matsuki, K., Omoto, K., and Juji, T.: Direct sequencing of a HLA-DRB gene by polymerase chain reaction: sequences variation in DRw8 specificity. Japn J Human Genet 35: 151–157, 1990

  15. Wu, S., Lu, D., Madden, M., Liu, C.-P., Miyokawa, N., Bach, F. H., and Saunders, T. L.: Full-lenght DQβ cDNA sequences of HLA-DR2/DQw1 subtypes: Genetic interactions between two DQβ loci generate human class II HLA diversity. Hum Immunol 27: 305–322, 1990

  16. WHO Nomenclature Committee: Nomenclature for factors of the HLA system, 1987. Vox Sang 55: 119–126, 1987

  17. Zemmour, J., Koller, B. H., Ennis, P. D., Geraghty, D. E., Lawlor, D. A., Orr, H. T., and Parham, P.: HLA-AR, an inactivated antigen-presenting locus related to HLA-A; implications for the evolution of the MHC. J Immunol 144: 3619–3629, 1990

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Zemmour, J., Parham, P. HLA class I nucleotide sequences, 1991. Immunogenetics 33, 310–320 (1991). https://doi.org/10.1007/BF00216690

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  • Nucleotide
  • Acid Number
  • Nucleotide Sequence
  • Sequence Alignment
  • Amino Acid Number