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Different recognition of transgenic HLA-DQw6 molecules by mouse CD4+ and CD8+ T cells

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  1. Golding, H. and Singer, A.: Role of accessory cell processing and presentation of shed H-2 alloantigens in allospecific cytotoxic T lymphocyte responses. J Immunol 133: 597–605, 1984

  2. Greenstein, J. L., Foran, J. A., Gorga, J. C., and Burakoff, S. J.: The role of T cell accessory molecules in the generation of class II-specific xenogeneic cytolytic T cells. J Immunol 136: 2358–2363, 1986

  3. Holterman, M. J., and Engelhard, V. H.: HLA antigens expressed on murine cells are preferentially recognized by murine cytotoxic T cells in the context of the H-2 major histocompatibility complex. Proc Natl Acad Sci USA 83: 9699–9703, 1986

  4. Kievits, F., Wijffels, J., Lokhorst, W., and Ivanyi, P.: Recognition of xeno-(HLA, SLA) major histocompatibility complex antigens by mouse cytotoxic T cells is not H-2 restricted: A study with transgenic mice. Proc Natl Acad Sci USA 86: 617–620, 1989

  5. Maryanski, J. L., Accolla, R. S., and Jordan, B.: H-2 restricted recognition of cloned HLA class I gene products expressed in mouse cells. J Immunol 136: 4340–4347, 1986

  6. Matzinger, P. and Bevan, M. J.: Why do so many lymphocytes respond to major histocompatibility antigens? Cell Immunol 29: 1–5, 1977

  7. Moses, R. D., Pierson, R. N. III, Winn, H. J., and Auchincloss, H. Jr.: Xenogeneic proliferation and lymphokine production are dependent on CD4+ helper T cells and self antigen presenting cells in the mouse. J Exp Med 172: 567–575, 1990

  8. Newell, M. K., Haughn, L. J., Maroun, C. R., and Julius, M. H.: Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen. Nature 347: 286–289, 1990

  9. Nishimura, Y., Iwanaga, T., Inamitsu, T., Yanagawa, Y., Yasunami, M., Kimura, A., Hirokawa, K., and Sasazuki, T.: Expression of the human MHC, HLA-DQw6 genes alters the immune response in C57BL/6 mice. J Immunol 145: 353–360, 1990

  10. Samaan, A., Gillet, D., Chopin, M., Degos, L., and Pla, M.: Mouse cytotoxic T cells can recognize HLA-B27 antigen without H-2 restriction. Immunogenetics 29: 210–212, 1989

  11. Shinohara, N., Bluestone, J. A., and Sachs, D. H.: Cloned cytotoxic T lymphocytes that recognize an I-A region product in the context of a class I antigen. J Exp Med 163: 972–980, 1986

  12. Townsend, A. R. M., Gotch, F. M., and Davey, J.: Cytotoxic T cells recognize fragments of the influenza nucleoprotein. Cell 42: 457–467, 1985

  13. Vogel, J. M., Davis, A. C., McKinney, D. M., McMillan, M., Martin, W. J., and Goodenow, R. S.: Molecular characterization of the C3HfB/HeN H-2Kkm2 mutation. J Exp Med 168: 1781–1800, 1988

  14. Yoshizawa, K. and Yano, A.: Mouse T lymphocytes proliferative responses specific for human MHC products in mouse anti-human xenogeneic MLR. J Immunol 132: 2820–2829, 1984

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Address correspondence and offprint requests to: T. Sasazuki.

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Inamitsu, T., Nishimura, Y. & Sasazuki, T. Different recognition of transgenic HLA-DQw6 molecules by mouse CD4+ and CD8+ T cells. Immunogenetics 35, 46–50 (1992).

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