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Transmission and scanning electron-microscopic observations on tanycytes in the mediobasal hypothalamus and the median eminence of adrenalectomized rats

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Summary

Tanycytes in the median eminence (ME) of the rat exhibit morphological features suggesting their possible participation in transport phenomena. After adrenalectomy, which modifies the hypothalamo-hypophyseal axis, they undergo morphological changes characterized by an accumulation of lipid droplets, an increased number of bleb-like protrusions at their apex, as well as an increased pinocytosis of intraventricularly injected horseradish peroxidase (HRP). In addition, after adrenalectomy an increased number of vacuoles appears at the level of the tubero-infundibular sulci. Their intracellular location in the tanycytes is demonstrated by an intraventricular injection of HRP. The significance of these vacuoles is discussed in relation to the hydroelectrolytic modifications associated with the state of adrenalectomy.

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Author information

Correspondence to Dr. J. Flament-Durand.

Additional information

Supported by a Fonds Lekime-Ropsy Award

Supported by grants: 20472 from the “Fonds de la Recherche Scientifique Médicale”; and 40025 from the “Fonds National de la Recherche Scientifique”

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Brion, J.P., Depierreux, M., Couck, A.M. et al. Transmission and scanning electron-microscopic observations on tanycytes in the mediobasal hypothalamus and the median eminence of adrenalectomized rats. Cell Tissue Res. 221, 643–655 (1982). https://doi.org/10.1007/BF00215708

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Key words

  • Tanycytes
  • Mediobasal hypothalamus
  • Median eminence
  • Adrenalectomy
  • Transport phenomena