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De novo sn-glycerol-3-phosphorylcholine synthetase activity in lung and muscle and its subcellular location

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Abstract

The activity of glycerophosphorylcholine synthetase, a newly discovered enzyme involved in the synthesis of acyl-specific phosphatidylcholines, is reported in rat lung and muscle. Its subcellular location appears to be mitochondrial. The implication of these findings in the synthesis of lung surfactant and the pathology of muscular dystrophy are discussed.

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Correspondence to J. P. Infante.

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Infante, J.P. De novo sn-glycerol-3-phosphorylcholine synthetase activity in lung and muscle and its subcellular location. Mol Cell Biochem 71, 135–137 (1986). https://doi.org/10.1007/BF00214772

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Keywords

  • glycerophosphorylcholine
  • phosphatidylcholine
  • mitochondria
  • lung surfactant
  • muscular dystrophy
  • calcium pump