Springer Nature is making Coronavirus research free. View research | View latest news | Sign up for updates

De novo sn-glycerol-3-phosphorylcholine synthetase activity in lung and muscle and its subcellular location

  • 16 Accesses

  • 18 Citations


The activity of glycerophosphorylcholine synthetase, a newly discovered enzyme involved in the synthesis of acyl-specific phosphatidylcholines, is reported in rat lung and muscle. Its subcellular location appears to be mitochondrial. The implication of these findings in the synthesis of lung surfactant and the pathology of muscular dystrophy are discussed.

This is a preview of subscription content, log in to check access.


  1. 1.

    Infante JP: Biosynthesis of acyl-specific glycerophospholipids in mammalian tissues. Postulation of new pathways. FEBS Lett 170:1–14, 1984.

  2. 2.

    Infante JP: Impaired glycerophosphorylcholine synthesis in murine muscular dystrophy. Med Biol 63:81–87, 1985.

  3. 3.

    Infante JP: Defective synthesis of glycerophosphorylcholine in murine muscular dystrophy: the primary molecular lesion? FEBS Lett 186:205–210, 1985.

  4. 4.

    Infante JP: Impaired biosynthesis of highly unsaturated phosphatidylcholines: a hypothesis on the molecular etiology of some muscular dystrophies. J Theor Biol 116:65–88, 1985.

  5. 5.

    Owens K, Hughes BP: Lipids of dystrophic and normal mouse: whole tissues and particulate fractions. J Lipid Res 11:486–495, 1970.

  6. 6.

    MacLennan DH: Isolation of proteins of the sarcoplasmic reticulum. Meth Enzymol 32:191–302, 1974.

  7. 7.

    Rooney SA: The surfactant system and lung phospholipid biochemistry. Am Rev Respir Dis 131:439–460, 1985.

  8. 8.

    Farrel PM, Avery ME: Hyaline membrane disease. Am Rev Respir Dis 111:657–688, 1975.

  9. 9.

    Jacobs HC, Ikegami M, Jobe AH, Berry DD, Jones S: Reutilization of surfactant phosphatidylcholine in adult rabbits. Biochim Biophys Acta 837:77–84, 1985.

  10. 10.

    Kaitaranta JK: High-performance liquid chromatographic separation of phospholipid precursors and their direct measurement by automatic phosphorous analysis. J Chromatogr 206:327–332, 1981.

  11. 11.

    Robinson S, Snoswell AM, Runciman B, Upton RN: Uptake and output of various forms of choline by organs of the conscious chronically catheterized sheep. Biochem J 217:399–408, 1984.

  12. 12.

    Martonosi A, Halpin RA: Sarcoplasmic reticulum. XVII. The turnover of proteins and phospholipids in sarcoplasmic reticulum membranes. Arch Biochem Biophys 152:440–450, 1972.

  13. 13.

    Burt CT, Pluskal MG, Sreter FA: Generation of phosphodiesters during fast-to-slow muscle transformation. Biochim Biophys Acta 721:492–494, 1982.

  14. 14.

    Shafiq SA, Gorycki MA, Milhorat AT: An electron microscope study of fibre types in normal and dystrophic muscles of the mouse. J Anat 104:281–293, 1969.

  15. 15.

    Okano G, Matsuzaka H, Shimojo T: Study of the lipid composition of white, intermediate, red and heart muscle in rats. Biochim Biophys Acta 619:167–175, 1980.

  16. 16.

    Infante JP: Defective synthesis of polyunsaturated phosphatidylcholines as the primary lesion in Duchenne and dy murine muscular dystrophies. Med Hypoth 19:113–116, 1986.

  17. 17.

    Wrogemann K, Pena SDJ: Mitochondrial calcium overload: a general mechanism for cell-necrosis in muscle diseases. Lancet i:672–674, 1976.

  18. 18.

    Mezon BJ, Wrogemann K, Blanchair MC: Differing populations of mitochondria isolated from the skeletal muscle of normal and dystrophic hamsters. Can J Biochem 52:1024–1032, 1974.

  19. 19.

    Rasmussen H, Palmieri GM: Altered cell calcium metabolism in human diseases. In: Rubin RP, Weiss GB, Putney JW (eds) Calcium in Biological Systems. Plenum Publishing Corporation, New York, 1985, pp 551–568.

Download references

Author information

Correspondence to J. P. Infante.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Infante, J.P. De novo sn-glycerol-3-phosphorylcholine synthetase activity in lung and muscle and its subcellular location. Mol Cell Biochem 71, 135–137 (1986).

Download citation


  • glycerophosphorylcholine
  • phosphatidylcholine
  • mitochondria
  • lung surfactant
  • muscular dystrophy
  • calcium pump