Advertisement

Psychopharmacology

, Volume 94, Issue 4, pp 566–568 | Cite as

Drop in heart rate following smoking cessation may be permanent

  • R. West
  • Nina Schneider
Original Investigations

Abstract

Data are reported on the heart rates of nine smokers who underwent 5 weeks of abstinence. There was an initial fall of 9.1 beats per min from 79 to 69.9 beats per min on the 1st day, with no significant change thereafter. The average heart rates after 2, 3, 4 and 5 weeks were 69.1, 69.1, 71.7 and 69.9 beats per min, respectively. Heart rate after 5 weeks was still significantly below baseline. The results indicate that the drop in heart rate which occurs open smoking abstinence is either a permanent change, or if it is a temporary withdrawal effect lasts longer than 5 weeks. If it is a permanent change then it may not make sense to consider drop in heart rate as part of a withdrawal syndrome; it could merely reflect absence of nicotine's stimulant action.

Key words

Heart rate Nicotine Smoking Time course Withdrawal 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Benowitz NL, Jacob P, Jones RT, Rosenberg J (1982) Inter-individual variability in the metabolism and cardiovascular effects of nicotine in man. J Pharmacol Exp Ther 221:368–372Google Scholar
  2. Diagnostic and statistical manual for mental disorders, DSM-III-R (3rd edn revised) (1987) Washington DC; American Psychiatric AssociationGoogle Scholar
  3. Gilbert RM, Pope MA (1982) Early effects of quitting smoking. Psychopharmacology 285:537–540Google Scholar
  4. Hughes J, Hatsukami D (1988) Signs and symptoms of tobacco withdrawal. Arch Gen Psychiatry (in press)Google Scholar
  5. Penny WJ, Mir MA (1986) Cardiorespiratory response to exercise before and after acute-adrenoreceptor blockade in non-smokers and chronic smokers. Int J Cardiol 11:293–304Google Scholar
  6. Schneider N, Jarvik M, Forsythe A, Read L, Elliott M, Schweiger A (1983) Nicotine gum in smoking cessation: a placebo-controlled, double blind trial. Addict Behav 8:253–261Google Scholar
  7. Schneider N, Jarvik M, Forsythe A (1984) Nicotine vs. placebo gum in the alleviation of withdrawal during smoking cessation. Addict Behav 9:149–156CrossRefPubMedGoogle Scholar
  8. Stolerman I, Fink R, Jarvik M (1973) Acute and chronic tolerance to nicotine measured by activity in rats. Psychopharmacology 30:329–342Google Scholar
  9. West R, Russell M (1987) Cardiovascular and subjective effects of smoking before and after 24 hours of abstinence from cigarettes. Psychopharmacology 92:118–121Google Scholar
  10. West R, Russell M, Jarvis M, Pizzie T, Kadam B (1984) Urinary adrenaline concentrations during 10 days of smoking abstinence. Psychopharmacology 84:141–142Google Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • R. West
    • 1
  • Nina Schneider
    • 2
    • 3
  1. 1.Psychology Department, Royal Holloway and Bedford New CollegeLondon UniversityEghamUK
  2. 2.Department of Psychiatry and Biobehavioral SciencesUniversity of CaliforniaLos AngelesUSA
  3. 3.Veterans Administration Medical CenterBrentwoodUSA

Personalised recommendations