Advertisement

Springer Nature is making Coronavirus research free. View research | View latest news | Sign up for updates

Detection of acalculous gallbladder disease using Tc99m EHIDA imaging and cholecystokinin

  • 23 Accesses

  • 4 Citations

Abstract

The use of Tc99m ethyl hepatic iminodiacetic acid (EHIDA) imaging with cholecystokinin (CCK) in a prospective study of 115 patients with right upper quadrant biliary-type pain is described. All patients had normal US, oral cholecystography and/or endoscopy investigations. A 2-min infusion of CCK was administered at peak gallbladder uptake of EHIDA. A gallbladder ejection fraction (CBEF) was used to quantify the gallbladder response to CCK. A total of 79 of 115 patients (69%) had an abnormal GBEF (≤ 35%). Of 43 patients who underwent cholecystectomy 42 (97%) had abnormal surgical/histological findings and/or complete long-term relief of symptoms. It was concluded that Tc99m EHIDA imaging, with a 2-min infusion of CCK and a measured GBEF ≤ 35%, is highly predictive of acalculous gallbladder disease and a favourable outcome following cholecystectomy.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Pickleman J, Peiss RL, Henkin R et al. (1985) The role of sincalide cholescintigraphy in the evaluation of patients with acalculous gallbladder disease. Arch Surg 120: 693–697

  2. 2.

    Raymond F, Lepanto L, Rosenthall L et al. (1988) Tc99m-IDA gallbladder kinetics and response to CCK in chronic cholecystitis. Eur J Nucl Med 14: 378–381

  3. 3.

    Westlake PJ, Hershfield NB, Kelly JK et al. (1990) Chronic right upper quadrant pain without gallstones: does HIDA scan predict outcome after cholecystectomy? Am J Gastroenterol 85: 986–990

  4. 4.

    Fink-Bennett D, DeRidder P, Kolozsi WZ et al. (1984) Cholecystokinin (CCK) functional cholescintigraphy (FC) in patinets suspected of acalculous biliary disease. J Nucl Med 25: p 10

  5. 5.

    Fink-Bennett D, DeRidder P, Kolozsi WZ et al. (1991) Cholecystokinin cholescintigraphy: detection of abnormal gallbladder motor function in patients with chronic acalculous gallbladder disease. J Nucl Med 32: 1695–1699

  6. 6.

    Misra DC, Blossom GB, Fink-Bennett D et al. (1991) Results of surgical therapy for biliary dyskinesia. Arch Surg 126: 957–960

  7. 7.

    Middleton GW, Williams JH (1992) Is gall bladder ejection fraction a reliable predictor of acalculous gall bladder disease? Nucl Med Commun 13: 894–896

  8. 8.

    Fink-Bennett D, DeRidder P, Kolozsi WZ et al. (1985) Cholecystokinin cholescintigraphy findings in the cystic duct syndrome. J Nucl Med 26: 1123–1128

  9. 9.

    Davis GB, Berk RN, Scheible FW et al. (1982) Cholecystokinin cholecystography, sonography and scintigraphy: detection of chronic acalculous cholecystitis. Am J Radiol 139: 515–523

  10. 10.

    Mesgarzadeh M, Krishnamurthy GT, Bobba VR et al. (1983) Filling, postcholecystokinin emptying, and refilling of normal gallbladder: effects of two different doses of CCK on refilling. J Nucl Med 24: 666–671

Download references

Author information

Additional information

Correspondence to: G. W. Middleton

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Middleton, G.W., Williams, J.H. Detection of acalculous gallbladder disease using Tc99m EHIDA imaging and cholecystokinin. Eur. Radiol. 4, 462–463 (1994). https://doi.org/10.1007/BF00212822

Download citation

Key words

  • Cholescintigraphy
  • Gallbladder ejection fraction GBEF
  • Cholecystokinin CCK