This experiment examined the effect of post-training d-amphetamine on retention in an appetitive autoshaping conditioning situation. Harlan Sprague-Dawley rats were first given ten autoshaping trials, followed by either three or four additional sessions of 50 trials (70 s intertrial interval) on which the conditioned stimulus (the extension of an illuminated Plexiglas lever for 10 s) and unconditioned stimulus (a 45 mg food pellet), were paired. d-Amphetamine (1 or 2 mg/kg) or saline was administered IP either immediately or 2 h following training. Rats injected with 1 mg/kg d-amphetamine immediately after the first training session made significantly more responses during the conditioned stimulus presentation on the following daily session of 50 trials. Thus, the amphetamine-treated rats acquired the lever press response faster than those given only saline. The amphetamine effects were time dependent: no significant effects were found if the injection was delayed until 2 h following training. These results agree with the findings of other instrumental aversive facilitation studies and suggest that d-amphetamine may enhance retention of the classically conditioned components of autoshaping.
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Benevento LA, Kandel GL (1967) Influence of strychnine on classically conditioned reflexes in the cat. J Comp Physiol Psychol 63:117–120
Brown P, Jenkins HM (1968) Autoshaping of the Pigeon's key peck. J Exp Anal Behav 11:1–8
Cholewiak RW, Hammond R, Seigler IC, Papsdorf JD (1968) The effects of strychnine sulphate on the classically conditioned nictitating membrane response of the rabbit. J Comp Physiol Psychol 66:77–81
Elisabetsky E, Vendite DA, Izquierdo I (1979) Memory channels in the rat: effect of post-training applications of potassium chloride on the hippocampus. Behav Neural Biol 27:354–361
Hernandez LE, Powell DA (1983) Naloxone induces multiple effects on aversive pavlovian conditioning in rabbits. Behav Neurosci 97 (3):478–491
Krivanek J, McGaugh JL (1969) Facilitating effects of pre and post-trial amphetamine administration on discrimination learning in mice. Agents Actions 1:36–42
Locurto CM, Terrace HS, Gibbon J (1981) Autoshaping and conditioning theory. Academic Press, New York
McGaugh JL (1966) Time-dependent processes in memory storage. Science 153:1351–1358
McGaugh JL (1968) Drug facilitation of memory and learning. In: Efron DH (ed) Psychopharmacology. A review of progress 1957–1967. Public Health Service Publication Number 1836, Washington DC, pp 891–904
McGaugh JL (1973) Drug facilitation of learning and memory. Annu Rev Pharmacol 13:229–241
Myer JS, Hull JH (1974) Autoshaping and instrumental learning in the rat. J Comp Physiol Psychol 86(4):724–729
Williams DR, Williams H (1969) Automaintenance in the pigeon: sustained pecking despite contingent non-reinforcement. J Exp Anal Behav 12:511–520
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Oscos, A., Martinez, J.L. & McGaugh, J.L. Effects of post-training d-amphetamine on acquisition of an appetitive autoshaped lever press response in rats. Psychopharmacology 95, 132–134 (1988). https://doi.org/10.1007/BF00212781
- Appetitive conditioning
- Facilitation of acquisition