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Immunotherapy of a guinea pig hepatoma with vaccines containing mycobacterial fractions

Comparison of cell walls and trehalose-6,6′-dimycolate

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Summary

BCG cell walls (CW) were compared to trehalose-6,6′-dimycolate (TDM) in admixture with endotoxin (ET) for their potency to cause regression of a transplanted guinea pig hepatoma. On a weight basis, CW were at least as active as ET-TDM. Toxicity of ET and of ET-TDM were greater than that of CW as judged by weight loss after intravenous administration to normal guinea pigs.

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Correspondence to H. J. Rapp.

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Rapp, H.J., Yarkoni, E., Ruco, L. et al. Immunotherapy of a guinea pig hepatoma with vaccines containing mycobacterial fractions. Cancer Immunol Immunother 3, 179–181 (1978). https://doi.org/10.1007/BF00205785

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Keywords

  • Cell Wall
  • Cancer Research
  • Intravenous Administration
  • Weight Basis