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Immunotherapy of a guinea pig hepatoma with vaccines containing mycobacterial fractions

Comparison of cell walls and trehalose-6,6′-dimycolate

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BCG cell walls (CW) were compared to trehalose-6,6′-dimycolate (TDM) in admixture with endotoxin (ET) for their potency to cause regression of a transplanted guinea pig hepatoma. On a weight basis, CW were at least as active as ET-TDM. Toxicity of ET and of ET-TDM were greater than that of CW as judged by weight loss after intravenous administration to normal guinea pigs.

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  1. Bast, R. C., Zbar, B., Borsos, T., Rapp, H. J.: BCG and Cancer. N. Engl. J. Med. 290, 1413–1420; 1458–1469 (1974)

  2. Bekierkunst, A.: Immunotherapy and vaccination against cancer with non-living BCG and cord factor (trehalose-6,6′-dimycolate). Int. J. Cancer 16, 442–447 (1975)

  3. Bekierkunst, A., Wang, L., Toubiana, R., Lederer, E.: Immunotherapy of cancer with non-living BCG and fractions derived from mycobacteria: Role of cord factor (trehalose-6,6′-dimycolate) in tumor regression. Infect. Immunity 10, 1044–1050 (1974)

  4. Lederer, E.: Cord factor and related trehalose esters. Chemistry Physics Lipids. 16, 91–106 (1976)

  5. Meyer, T. J., Ribi, E. E., Azuma, I., Zbar, B.: Biologically active components from mycobacterial cell walls. 2. Suppression and regression of strain-2 guinea pig hepatoma. J. Natl. Cancer Inst. 52, 103–111 (1974)

  6. Ribi, E. E., Granger, D. L., Milner, K. C., Strain, S. M.: Tumor regression caused by endotoxins and mycobacterial fractions. J. Natl. Cancer Inst. 55, 1253–1257 (1975)

  7. Sokal, R. R., Rohlf, F. J.: In: Biometry, p. 387. San Francisco: W. H. Freeman and Co. 1969

  8. Zbar, B., Wepsic, H. T., Rapp, H. J., Whang-Peng, J., Borsos, T.: Transplantable hepatoma induced in strain-2 guinea pigs by diethylnitrosamine: Characterization by histology, growth and chromosomes. J. Natl. Cancer Inst. 43, 821–831 (1969)

  9. Zbar, B., Rapp, H. J., Ribi, E. E.: Tumor suppression by cell walls of Mycobacterium bovis attached to oil droplets. J. Natl. Cancer Inst. 48, 831–835 (1972)

  10. Zbar, B., Ribi, E., Meyer, T., Azuma, I., Rapp, H. J.: Immunotherapy of cancer: Regression of established intradermal tumors after intralesional injection of mycobacterial cell walls attached to oil droplets. J. Natl. Cancer Inst. 52, 1571–1577 (1974)

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Correspondence to H. J. Rapp.

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Rapp, H.J., Yarkoni, E., Ruco, L. et al. Immunotherapy of a guinea pig hepatoma with vaccines containing mycobacterial fractions. Cancer Immunol Immunother 3, 179–181 (1978). https://doi.org/10.1007/BF00205785

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  • Cell Wall
  • Cancer Research
  • Intravenous Administration
  • Weight Basis