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Tumor immunity and autoimmunity produced by injection of antigens modified by adsorbed virus

Summary

C3H/Bi mice were injected repeatedly with isolated plasma membranes carrying adsorbed paramyxovirus antigens. The membranes prepared from a syngeneic ascitic lymphoma induced by the Gross leukemia virus by themselves stimulated little immune response but after treatment with concentrated virus, in some experiments they produced tumor transplant resistance and usually autoimmunity, as demonstrated by serological reactions and appearance of fatal autoimmune disease. Cytotoxic and complement-fixing antibodies against uninfected lymphoma and splenocytes were demonstrated. Autohemolysin related to an unidentified heterophile antigen also appeared. The relationship of autoimmunity, in timing and dose response, to tumor immunity is considered.

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Abbreviations

NDV:

Newcastle disease virus

Siv:

Sendai virus

PBS:

phosphate buffered saline

HA:

hemagglutination

NCM:

normal untreated lymphoma crude membrane

IP:

intraperitoneal

CFA:

complete Freund's adjuvant

CF:

complement fixation

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Correspondence to Monroe D. Eaton.

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Eaton, M.D., Almquist, S.J.P. Tumor immunity and autoimmunity produced by injection of antigens modified by adsorbed virus. Cancer Immunol Immunother 9, 199–205 (1980). https://doi.org/10.1007/BF00205626

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Keywords

  • Immune Response
  • Plasma Membrane
  • Lymphoma
  • Leukemia
  • Cancer Research