It is clear that a wide variety of methods for measuring immune complexes are available but some may have disadvantages, such as technical difficulty, and all suffer from a lack of satisfactory standardization (WHO, 1977). However, in spite of these difficulties, the measurement of immune complexes may itself prove useful in monitoring of patients, and the complexes may provide a route to the identification and isolation of tumor related products, which would allow a more direct quantitation of tumor burden.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Amlot, P. L., Slaney, J. M., Williams, B. D.: Circulating immune complexes and symptoms in Hodgkin's disease. Lancet 1976 I, 449
Baldwin, R. W.: In vitro assays of cell mediated immunity to human solid tumors: problems of quantitation, specificity and interpretation. J. nat. Cancer Inst. 55, 745 (1975)
Baldwin, R. W., Robins, R. A.: Factors interfering with immunological rejection of tumours. Brit. med. Bull. 32, 118 (1976)
Hay, F. C., Nineham, L. J., Roitt, I. M.: Routine assay for the detection of immune complexes of known immunoglobulin class using solid phase C1q. Clin. exp. Immunol. 24, 396 (1976)
Heier, H. E., Carpentier, N., Lange, G., Lambert, P. H., Godal, T.: Circulating immune complexes in patients with malignant lymphomas and solid tumours. Int. J. Cancer 20, 887 (1977)
Heier, H. E., Carpentier, N. A., Lambert, P. H., Godal, T.: Quantitation of serum complement components and plasma C3d in patients with malignant lymphoma: relation to the stage of disease and circulating immune complexes. Int. J. Cancer (in press, 1978)
Heimer, R., Klein, G.: Circulating immune complexes in sera of patients with Burkitt's lymphoma and nasopharyngeal carcinoma. Int. J. Cancer 18, 310 (1976)
Hellström, I., Hellström, K. E.: Studies on cellular immunity and its serum mediated inhibition in Moloney-virus-induced mouse sarcomas. Int. J. Cancer 4, 587 (1969)
Hellström, I., Sjögren, H. O., Warner, G. A., Hellström, K. E.: Blocking of cell mediated tumour immunity by sera from patients with growing neoplasms. Int. J. Cancer 7, 226 (1971)
Hellström, K. E., Hellström, I., Nepom, J. T.: Specific blocking factors — are they important? Biochim. biophys. Acta (Amst.) 473, 121 (1977)
Herberman, R. B., Oldham, R. K.: Problems associated with study of cell mediated immunity to human tumors by microcytotoxicity assays. J. nat. Cancer Inst. 55, 749 (1975)
Höffken, K., Meredith, I. D., Robins, R. A., Baldwin, R. W., Davies, C. J., Blamey, R. W.: Circulating immune complexes in patients with breast cancer. Brit. med. J. 2, 218 (1977)
Höffken, K., Meredith, I. D., Robins, R. A., Baldwin, R. W., Davies, C. J., Blamey, R. W.: Immune complexes and prognosis of human breast cancer. Lancet 1978 I, 672
Kaplan, B. S., Klassen, J., Gault, M. H.: Glomerular injury in patients with neoplasia. Ann. Rev. Med. 27, 117 (1976)
Lancet (editorial): Immune complexes in health and disease. Lancet 1977 I, 580
Levin, A. S., Höffken, K., Baldwin, R. W.: Solid phase fluoro-immunoassay to detect serum factors. Proc. VIth Int. Conference on Immunofluorescence and Related Staining Techniques, Vienna, April 1978 (in press)
Mikulska, S. M., Billing, R., Terasaki, P. T.: Inhibition of effector cell function in human antibody-dependent cellular cytotoxicity by sera from cancer patients. J. nat. Cancer Inst. 58, 1485 (1977)
Mukojima, T., Gunvén, P., Klein, G.: Circulating antibody-antigen complex associated with Epstein-Barr virus in recurrent Burkitt's lymphoma. J. nat. Cancer Inst. 51, 1319 (1973)
Murray, E., McCarthy, W. H., Hersey, P.: Blocking factors against leucocyte dependent melanoma antibody in the sera of melanoma patients. Brit. J. Cancer 36, 7 (1977)
Rossen, R. D., Reisberg, M. A., Hersh, E. M., Gutterman, J. U.: The C1q binding test for soluble immune complexes: clinical correlations obtained in patients with cancer. J. nat. Cancer Inst. 58, 1205 (1977)
Samoyoa, E. A., McDuffie, F. C., Nelson, A. M., Go, V. L. W., Luthra, H. S., Brumfield, H. W.: Immunoglobulin complexes in sera of patients with malignancy. Int. J. Cancer 19, 12 (1977)
Teshima, H., Wanebo, H., Pinsky, C., Day, N. K.: Circulating immune complexes detected by 125I-C1q deviation test in sera of cancer patients. J. clin. Invest. 59, 1134 (1977)
Theofilopoulos, A. N., Andrews, B. S., Urist, M. M., Morton, D. L., Dixon, F. J.: The nature of immune complexes in human cancer sera. J. Immunol. 119, 657 (1977)
World Health Organization: The role of immune complexes in disease. Wld. Hlth. Org. Tech. Rep. Ser. 606 (1977)
About this article
Cite this article
Robins, R.A., Baldwin, R.W. Immune complexes in cancer. Cancer Immunol Immunother 4, 1–3 (1978). https://doi.org/10.1007/BF00205563