To study the mechanism of the therapeutic effect of intratumoral injection of immunostimulants in tumors, an experimental model was designed. This model includes six rat tumors and six mouse tumors which can be compared for different parameters: susceptibility or resistance to various immunostimulants injected intralesionally, histological characteristics, and immunogeneicity. This complex model is described in the present paper.
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Morton, D. L., Eilber, F. R., Malmgren, R. A., Wood, W. C.: Immunological factors which influence response to immunotherapy in malignant melanoma. Surgery 68, 158 (1970)
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Salomon, J., Lynch, N. Intralesional injection of immunostimulants in rat and mouse tumors. Cancer Immunol Immunother 1, 145–151 (1976). https://doi.org/10.1007/BF00205458
- Cancer Research
- Experimental Model
- Therapeutic Effect
- Complex Model
- Histological Characteristic