The purpose of this study is to collaborate with clinicians who are involved in the treatment of certain types of cancer with BCG. Different massive doses of BCG were inoculated by various routes in small animals and three types of toxicity were studied: acute, chronic, and subacute toxicity. It is shown that BCG is not toxic mainly on the basis of mortality and weight variations of animals. Surprisingly, it was found that small animals could survive several doses of 2000 mg/kg of weight, by the subcutaneous route.
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Portelance, V., Quevillon, M. & Page, Y. Toxic effects of massive doses of BCG in mice, guinea pigs, and monkeys. Cancer Immunol Immunother 1, 63–67 (1976). https://doi.org/10.1007/BF00205296
- Cancer Research
- Toxic Effect
- Small Animal
- Weight Variation
- Subcutaneous Route