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IL9 maps to mouse chromosome 13 and human chromosome 5

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Abstract

Mouse and human cDNA clones encoding the T-cell and mast cell growth factor P40, now designated IL-9, were used to identify DNA restriction fragment length polymorphisms (RFLPs) in sets of somatic cell hybrids and between inbred strains of mice and interspecific backcross progeny. Segregation of mouse and human chromosomes among somatic cell hybrids indicated a location on mouse chromosome 13 and human chromosome 5. RFLPs were identified among inbred strains of mice. Analysis of chromosome 13 alleles for Tcrg, Dhfr, and Il-9 in an interspecific cross between Mus musculus and NFS/N or C58/J mice indicates that IL-9 is distal to Tcrg and Proximal to Dhfr.

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References

  1. Chang, A. C. Y., Nunberg, J. H., Kaufman, R. J., Erlich, H. A., Schimke, R. T., and Cohen, S. N.: Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase. Nature 275: 617–624, 1978

  2. Frankel, W. N., Stoye, J. P., Taylor, B. A.., and Coffin, J. M.: Genetic analysis of endogenous xenotropic murine leukemia viruses: association with two common mouse mutations and the viral restriction locus Fv-1. J Virol 63: 1763–1777, 1989

  3. Green, E. L.: Linkage, recombination and mapping. In E. L. Green (ed.): Probability in Animal Breeding Experiments, pp. 77–113, MacMillan, New York, 1981

  4. Hoggan, M. D., Halden, N. F., Buckler, C. E.., and Kozak, C. A.: Genetic mapping of the mouse c-fms protooncogene to chromosome 18. J Virol 62: 1055–1056, 1988

  5. Hultner, L.., Moeller, J., Schmitt, E., Jager, G., Reisbach, G., Ring, J., and Dormer, P.: Thiol-sensitive mast cell growth-enhancing activity different from both IL-3 and IL-4. J Immunol 142: 3440–3446, 1989

  6. Huppi, K., D'Hoostelaere, L., Kiefer, M., Steinmetz, M., and Jouvin-Marche, E.: The context of T-cell receptor gamma chain genes among wild mouse species. Immunogenetics 24: 304–308, 1986

  7. LeBeau, M. M., Westbrook, C. A., Diaz, M. O.., Larson, R. A., Rowley, J. D., Gasson, J. C., Golde, D. W., and Sherr, C. J.: Evidence for the involvement of GM-CSF in the deletion (5q) in myeloid disorders. Science 231: 984–987, 1986

  8. McBride, O. W., Battey, J., Hollis, G. F., Swan, D., Siebenlist, U., and Leder, P.: Localization of human variable and constant region immunoglobulin heavy chain genes on subtelomeric band q32 of chromosome 14. Nucleic Acids Res 10: 8155–8170, 1982a

  9. McBride, O. W., Hieter, P. A., Hollis, G. F.., Swan, D., Otey, M. C., and Leder, P.: Chromosomal location of human kappa and lambda immunoglobulin light chain constant region genes. J Exp Med 155: 1480–1490, 1982b

  10. McBride, O. W., Swan, D. C., Tronick, S. R., Gol, R., Klimanis, D., Moore, D. E., and Aaronson, S. A.: Regional localization of N-ras, K-ras-1, K-ras-2 and myb oncogenes in human cells. Nucleic Acids Res 11: 8221–8236, 1983

  11. McKusick, V. A.: The human gene map. Cytogenet Cell Genet 46: 1–566, 1987

  12. Mock, B. A., D'Hoostelaere, L. A., Matthai, R., and Huppi, K.: A mouse homeo box gene, Hox-1.5, and the morphological locus, Hd, map to within 1 cM on chromosome 6. Genetics 116: 607–612, 1987

  13. Mock, B. A., Givol, D., D'Hoostelaere, L. A., Huppi, K., Seldin, M. F., Gurfinkel, N., Unger, T., and Potter, M.: Mapping of the bcl-2 oncogene on mouse chromosome 1. Cytogenet Cell Genet 47: 11–15, 1988

  14. Moeller, J., Hultner, L., Schmitt, E., and Dormer, E.: Partial purification of a mast cell growth-enhancing activity and its separation from IL-3 and IL-4. J Immunol 142: 3447–3451, 1989

  15. Nadeau, J. H. and Reiner, A. H.: Linkage and synteny homologies in mouse and man. Curr Top Microbiol Immunol 137: 39–40, 1988

  16. Nienhuis, A. W., Bunn, H. F., Turner, P. H., Gopal, T. V., Nash, W. G., O'Brien, S. J., and Sherr, C. J.: Expression of the human c-fms protooncogene in hematopoietic cells and its deletion in the 5q- syndrome. Cell 42: 421–428, 1985

  17. Nimer, S. D. and Goldie, D. W.: The 5q- abnormality. Blood 70: 1705–1712, 1987

  18. Pettenati, M. J., LeBeau, M. M., Lemons, R. S., Shima, E. A., Kawaski, E. S., Larson, R. A., Sherr, C. J., Diaz, M. O., and Rowley, J. D.: Assignment of CSF-1 to 5q33. 1: evidence for clustering of genes regulating hematopoiesis and for their involvement in the deletion of the long arm of chromosome 5. Proc Natl Acad Sci USA 84: 2970–2974, 1987

  19. Potter, M., Nadeau, J. H., and Cancro, M. P.: The wild mouse in immunology. Curr Top Microbiol Immunol 127: 373–395, 1986

  20. Renauld, J.-C., Goethals, A., Houssiau, F., Van Roost, E., and Van Snick. J.: Cloning and expression of a cDNA for the human homolog of mouse T cell and mast cell growth factor P40. Cytokine, in press, 1990

  21. Silver, J.: Confidence limits for estimates of gene linkage based on analysis of recombinant inbred strains. J Hered 76: 436–440, 1985

  22. Taylor, B. A.: Recombinant inbred strains: use in gene mapping. In H. C. Morse (ed.): Origins of Inbred Mice, pp. 423–438, Academic, New York, 1978

  23. Uyttenhove, C., Simpson, R. J., and Van Snick, J.: Functional and structural characterization of P40, a mouse glycoprotein with T cell growth factor activity. Proc Natl Acad Sci USA 85: 6934–6938, 1988

  24. Van Snick, J., Goethals, A., Renauld, J.-C., Van Roost, E., Uyttenhove, C., Rubira, M. R., Mortiz, R. L., and Simpson, R. J.: Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40). J Exp Med 169: 363–368, 1989

  25. Yang, Y.-C., Ricciardi, S., Ciarletta, A., Calvetti, J., Kelleher, K., and Clark, S. C.: Expression cloning of a cDNA encoding a novel human hematopoietic growth factor: human homologue of murine T-cell growth factor P40. Blood 74: 1880–1884, 1989

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Correspondence to Beverly A. Mock.

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Mock, B.A., Krall, M., Kozak, C.A. et al. IL9 maps to mouse chromosome 13 and human chromosome 5. Immunogenetics 31, 265–270 (1990). https://doi.org/10.1007/BF00204898

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Keywords

  • Cell Growth
  • Mast Cell
  • Fragment Length
  • Length Polymorphism
  • Restriction Fragment Length Polymorphism