Advertisement

Springer Nature is making Coronavirus research free. View research | View latest news | Sign up for updates

Das vorhandensein von methadon im apokrinen schweiß beim menschen

The presence of methadone in human apocrine sweat

  • 21 Accesses

Summary

The presence of methadone was investigated in 24-h perspiration samples obtained from patients receiving daily maintenance doses of the drug. The samples were collected from the axillary region. The concentrations measured by radioimmunoassay ranged from 8.3 ng/cm2 per 24 h up to 25.3 ng/cm2 per 24 h. The concentrations determined by RIA are the sum of methadone and its metabolites. The presence of the drug in the perspiration samples was also revealed by GC/MS.

Zusammenfassung

Es wurden Untersuchungen zum Nachweis von Methadon im apokrinen Schweiß durchgeführt. Die Schweißproben wurden von der Achselregion von Patienten, die unter Methadontherapie standen, in einer 24-Stunden-Sammelperiode gewonnen. Die mittels RIA gemessenen Konzentrationen lagen im Bereich von 8,3 ng/cm2/24 Std. bis 25,3 ng/cm2/24 Std. Die Werte stellen die Summe von Methadon und Metaboliten dar. Das Vorhandensein von Methadon im Schweiß wurde zusätzlich mittels GC/MS bestätigt.

This is a preview of subscription content, log in to check access.

Literatur

  1. Balabanova S, Wolf HU (1989a) Methadone concentrations in human hair of the head, axillary and pubic hair. Z Rechtsmed 102:293–296

  2. Balabanova S, Brunner H, Arnold PJ, Luckow V, Wolf HU (1989b) Detection of Methadone in human hair by gas chromatography/mass spectrometry. Z Rechtsmed 102:495–501

  3. Dole VP, Kreek MJ (1973) Methadone plasma level: sustained by a reservoir of drug in tissue. Proc Natl Acad Sci USA 70:10

  4. Inturrisi CE, Verebely K (1972) The levels of methadone in the plasma in methadone maintenance. Clin Pharmacol Ther 13:633–637

  5. Kaufmann JJ, Koski WS, Benson DW, Demo NM (1975) Measurement of the pKa's partition and drug distribution coefficient of narcotics antagonists, their pH and temperature dependence, and their significance in clinical practice. Proc Committee Probl Drug Depend 433–352

  6. Mutschler E (1975) Arzneimittel Wirkungen, Lehrbuch für Pharmazeuten, Chemiker und Biologen, 3. Aufl. Wissenschaftliche Verlagsgesellschaft, Stuttgart, S 10

  7. Verebely K, Volavka MD, Mulé S, Resnick R (1975) Methadone in man: pharmacokinetic and excretion studies in acute and chronic treatment. Clin Pharmacol Ther 18:180–190

Download references

Author information

Correspondence to S. Balabanova.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Balabanova, S., Schneider, E., Bühler, G. et al. Das vorhandensein von methadon im apokrinen schweiß beim menschen. Z Rechtsmed 103, 323–327 (1990). https://doi.org/10.1007/BF00204452

Download citation

Key word

  • Methadone presence in perspiration

Schlüsselwört

  • Methadon im Schweiß