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A new model for occluding the left coronary artery in the rabbit without thoracotomy

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Abstract

A small, nonmagnetic coil was fluoroscopically guided into the left circumflex coronary artery (LCXA) at the midventricular level via the left femoral artery in seven rabbits. Coronary artery occlusion was confirmed by intracoronary contrast injection, electrocardiographic changes, akinesis of the posterolateral wall distal to the occluded area, and histopathological staining of the myocardium. This new model of a closed-chest coronary artery occlusion in the rabbit may be suitable for acute ischemic myocardium studies that do not require reperfusion.

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Correspondence to Nikita Derugin.

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Derugin, N., Masui, T. & Konishi, Y. A new model for occluding the left coronary artery in the rabbit without thoracotomy. Cardiovasc Intervent Radiol 18, 340–342 (1995). https://doi.org/10.1007/BF00203690

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Key words

  • Rabbit
  • Coronary artery occlusion
  • Coil emboli
  • Closed-chest model
  • Myocardial infarction