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Hepatitis a virus infection of HBsAg-producing hepatocellular carcinomas in athymic mice

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Two human hepatocellular carcinoma cell lines were grown in athymic mice. Morphologically, the tumors resembled hepatocellular carcinomas. HBsAg, anti-HBs, and α-fetoprotein were detected in sera of mice bearing tumors of PLC/PRF/5 or Hep 3B cells; their amounts correlated with tumor weight. Tumors of both cell lines were infected with cell culture-adapted hepatitis A virus (HAV); HAV antigen and infectious virus were recovered from infected tumors of PLC/PRF/5 and Hep 3B cells. Our results indicate that HAV-infected tumors may be useful in studying the production in vivo of hepatitis A virus antigen.

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Correspondence to Verena Gauss-Müller.

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Gauss-Müller, V., Deinhardt, F., Hahn, E. et al. Hepatitis a virus infection of HBsAg-producing hepatocellular carcinomas in athymic mice. Cancer Immunol Immunother 13, 53–55 (1982). https://doi.org/10.1007/BF00200201

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  • Carcinoma
  • Hepatitis
  • Carcinoma Cell
  • Virus Infection
  • Hepatocellular Carcinoma