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Effect of ALS or ATS administration on tumor formation in two-stage skin carcinogenesis

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When given during initiation, antithymocyte serum (ATS) increased tumor incidence by 83%, increased the number of tumors per animal from 2.6 to 4.2, and caused a decrease in the latent period to appearance of the first tumor by 27% as compared to animals receiving only 9,10-dimethylbenzo(a)anthracene (DMBA) as initiating agent and phorbolmyristateacetate (TPA) as promotor. The effect of ATS when given during promotion was less pronounced: tumor incidence was increased by 50% and the average number of tumors per animal was 3.1. Antilymphocyte serum (ALS) given during initiation caused an increase in tumor incidence by 33% and the average number of tumors was 3.1 per animal. When ALS was given during promotion the effect on tumor formation was neglibible, i.e., 52 tumors were observed in 21 animals, as against 48 tumors in 18 DMBA/TPA-treated animals.

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Stenbäck, F., Curtis, G. & Ryan, W. Effect of ALS or ATS administration on tumor formation in two-stage skin carcinogenesis. Cancer Immunol Immunother 6, 125–128 (1979). https://doi.org/10.1007/BF00200142

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  • Cancer Research
  • Latent Period
  • Anthracene
  • Tumor Formation
  • DMBA