Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Immunoprophylaxis toward mammary carcinoma in mice immune to Listeria monocytogenes

Summary

The growth of a transplantable mammary carcinoma in C3H and DBA mice was suppressed in animals immune to Listeria monocytogenes (LM). When tumor cells were mixed with live bacteria at the time of transplantation, experimental LM-immune animals survived a lethal dose of tumor cells. Treatment of non-immune animals with tumor cells plus LM was ineffective. Immunity to LM was therefore a prerequisite of antitumor protection.

The destruction of tumor cells was most likely a nonspecific side effect of the immune reaction to LM, since administration of LM at the same site as tumor cells was necessary. Despite this nonspecific mode of tumor suppression, animals which were protected from progressive tumor growth nevertheless developed specific antitumor immunity, being able to resist a secondary challenge by a lethal dose of syngeneic tumor cells.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Bartlett, G. L., Zbar, B., Rapp, H. J.: Suppression of murine tumor growth by immune reaction to the Bacillus-Calmette-Guerin strain of Mycobacterium bovis. J. Natl. Canc. Inst. 48, 245 (1972)

  2. 2.

    Bast, Jr. R. C., Zbar, B., Mackaness, G. B., Rapp, H. J.: Antitumor activity of bacterial infection. I. Effect of Listeria monocytogenes on growth of a murine fibrosarcoma. J. Natl. Canc. Inst. 54, 749 (1975)

  3. 3.

    Gershon, R. K., Carter, R. L., Kondo, K.: On concomitant immunity in tumor-bearing hamsters. Nature 213, 674 (1967)

  4. 4.

    Hawrylko, E., Mackaness, G. B.: Immunopotentiation with BCG. IV. Factors affecting the magnitude of an antitumor response. J. Natl. Canc. Inst. 51, 1683 (1973)

  5. 5.

    Hawrylko, E.: Immunopotentiation with BCG: Dimensions of a specific antitumor response. J. Natl. Canc. Inst. 54, 1189 (1975)

  6. 6.

    Hibbs, J. B., Lambert, L. H., Remington, J. S.: Possible role of macrophage mediated nonspecific cytotoxicity in tumor resistance. Nature New Biol. 235, 48 (1972)

  7. 7.

    Klein, E.: Tumors of the skin. Immunotherapy of cutaneous and mucosal neoplasms. New York J. Med. 68, 900 (1968)

  8. 8.

    Krahenbuhl, J. L., Remington, J. S.: The role of activated macrophages in specific and nonspecific cytostasis of tumor cells. J. Immunol. 113, 507 (1974)

  9. 9.

    Lane, F. C., Unanue, E. R.: Immunologic events during Listeria monocytogenes infection in mice. Adjuvanticity and immunogenicity of macrophage-bound antigens. J. Immunol. 110, 829 (1973)

  10. 10.

    Leibowitch, J. L., David, J. R.: Lymphocyte-macrophage interaction in resistance to Listeria monocytogenes. Ann. Imm. (Inst. Past.) 124C, 441 (1973)

  11. 11.

    Mackaness, G. B.: The influence of immunologically committed lymphoid cells on macrophage activity in vivo. J. Exp. Med. 129, 973 (1969)

  12. 12.

    Mackaness, G. B., Blanden, R. V.: Cellular immunity. Progr. Allergy 11, 89 (1967)

  13. 13.

    Mackaness, G. B., Auclair, D. J., Langrange, P. H.: Immunopotentiation with BCG. I. Immune response to different strains and preparations. J. Natl. Canc. Inst. 51, 1655 (1973)

  14. 14.

    Yashphe, D. J.: Immunological factors in nonspecific stimulation of host resistance to syngeneic tumors. A review. Isr. J. Med. Sci. 7, 90 (1971)

  15. 15.

    Youdim, S.: Resistance to tumor growth mediated by Listeria monocytogenes. Destruction of experimental malignant melanoma by LM-activated peritoneal and lymphoid cells. J. Immunol. 116, 579 (1976)

  16. 16.

    Youdim, S., Moser, M., Stutman, O.: Nonspecific suppression of tumor growth by an immune reaction to Listeria monocytogenes. J. Natl. Canc. Inst. 52, 193 (1974)

Download references

Author information

Correspondence to E. Skamene.

Additional information

Present address: Department of Surgery (Urology), Mount Sinai Hospital, Toronto, Ontario, Canada. Dr. Buckspan was the recipient of an Irving Howard Cameron Memorial Scholarship

Recipient of the Monat Award from McGill University

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Buckspan, M., Hojvat, S. & Skamene, E. Immunoprophylaxis toward mammary carcinoma in mice immune to Listeria monocytogenes . Cancer Immunol Immunother 3, 49–56 (1977). https://doi.org/10.1007/BF00199325

Download citation

Keywords

  • Tumor Cell
  • Listeria
  • Listeria Monocytogenes
  • Lethal Dose
  • Mammary Carcinoma