A glioblastoma patient was immunized in vivo with a mixture of autologous and homologous glioblastoma cells coupled to adjuvant peptide and cord-factor analog. Immune activity of peripheral blood lymphocytes was measured in a short-term 51chromium-release assay against autologous tumor target cells. The patient developed direct cell-mediated cytotoxicity against tumor-associated antigens, which appeared to be T-cell mediated.
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Eggers, A.E., Tarmin, L. & Gamboa, E.T. In vivo immunization against autologous glioblastoma-associated antigens. Cancer Immunol Immunother 19, 43–45 (1985). https://doi.org/10.1007/BF00199310
- Cancer Research
- Target Cell
- Immune Activity
- Blood Lymphocyte