Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Morphological variability of tumour cells in T-cell-rich B-cell lymphoma

A histopathological study of 14 cases

  • 34 Accesses

  • 21 Citations

Abstract

T-cell-rich B-cell lymphoma (TCRBCL) is an unusual lymphoma which is difficult to diagnose. A majority of reactive T-cells and numerous histiocytes mask the few large neoplastic B-cells. Fourteen cases of TCRBCL were studied in order to identify the main histological and cytological features useful for this diagnosis. Neoplastic cells are atypical and sometimes difficult to classify. Several types are seen; they are mostly centroblasts, which represent more than 50% of the tumour cells but are sometimes multilobated, immunoblasts- or Reed-Sternberg-like cells. Interestingly, at least two, and often three, types of tumour cell are present in all the cases. Epithelioid cells and histiocytes are always found and are often numerous. Hypervascularization and fibrosis are present in the majority of cases, but without annular bands. Necrosis is absent. All tumour cells express CD20 but EMA is expressed in less than half the cases. In two cases, the association of a diffuse large B-cell lymphoma in one site and a TCRBCL in another suggests that TCRBCL may be considered as a peculiar pattern of a diffuse large B-cell lymphoma with a strong stroma reaction. TCRBCL may not represent a clinicopathological entity.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Baddoura FK, Chan WC, Masih AS, Mitchell D, Sun NCJ, Weisenburger DD (1995) T-cell-rich B-cell lymphoma. A clinicopathological study of eight cases. Am J Clin Pathol 103:65–75

  2. 2.

    Betman H, Vardiman J, Lau J (1994) T-cell rich B-cell lymphoma of the spleen (letter). Am J Surg Pathol 18:323–324

  3. 3.

    Borg-Grech A, Radford JA, Crowther D, Swindell R, Harris N (1989) A comparative study of the nodular and diffuse variants of lymphocyte-predominant Hodgkin's disease. J Clin Oncol 7:1303–1309

  4. 4.

    Brouland JP, Molimard J, Nemeth J, Valleur P, Galian A (1993) Primary T-cell rich B-cell lymphoma of the common bile duct. Vichows Arch [A] 423:513–517

  5. 5.

    Brousset P, Chittal SM, Schlaifer D, Delsol G (1995) T-cell rich B-cell lymphoma in the lung. Histopathology 26:371–373

  6. 6.

    Chittal SM, Brousset P, Voigt J-J, Delsol G (1991) Large B-cell lymphoma rich in T-cells and simulating Hodgkin's disease. Histopathology 19:211–220

  7. 7.

    Delabie J, Vandenberghe E, Kennes C, Verhoef G, Foschini MP, Stul M, Cassiman JJ, De Wolf-Peeters C (1992) Histiocyte-rich B-cell lymphoma. Am J Surg Pathol 16:37–48

  8. 8.

    Delsol G, Lamant L, Brousset P, Al Saati T, Rigal Huguet F, Schlaifer D, d'Agay M.F, Fetissof F (1994) Immunomorphologic subtypes of T-cell rich B-cell lymphoma and their relationship to Hodgkin's disease. VII Meeting of EAHP, Toledo, 4 October 1994

  9. 9.

    Diebold J, Jungman P, Molina T, Audouin J (1995) Recent advances in Hodgkin's disease: an overview and review of the literature. Curr Diagn Pathol 2:153–162

  10. 10.

    Harris NL, Jaffe ES, Stein H, Banks PM, Chan JKC, Cleary M, Delsol G, De Wolf-Peeters C, Falini B, Gatter KC, Grogan TM, Isaacson PG, Knowles DM, Mason DY, Muller-Hermelink HK, Pileri S, Piris MA, Ralfkiaer E, Warnke RA (1994) A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 84:1361–1392

  11. 11.

    Jaffe ES, Logo DL, Cossman J, Hsu SM, Arnold A, Korsmeyer SJ (1984) Diffuse B-cell lymphomas with T-cell predominance in patients with follicular lymphoma or pseudo T cell lymphoma. Lab Invest 50:17A-28A

  12. 12.

    Khan SM, Cottrell BJ, Millward-Sadler GH, Wright DH (1993) T-cell rich B-cell lymphoma presenting as liver disease. Histopathology 23:217–224

  13. 13.

    Krishnan J, Wallberg K, Frizzera G (1994) T-cell rich B-cell lymphoma. A study of 30 cases supporting its histological heterogeneity and lack of clinical distinctiveness. Am J Surg Pathol 18:455–465

  14. 14.

    Lennert K, Hansmann ML (1987) Progressive transformation of germinal centers: clinical significance and lymphocytic predominance Hodgkin's disease. The Kiel experience. Am J Surg Pathol 11:149–150

  15. 15.

    Macon WR, Williams ME, Greer JP, Stein RS, Collins RD, Cousar JB (1992) T-cell-rich B-cell lymphomas, a clinicopathologic study of 19 cases. Am J Surg Pathol 16:351–363

  16. 16.

    Mirchandani I, Palutke M, Tabaczka P, Goldfarb S, Einsenberg L, Pak M (1985) B-cell lymphomas morphologically resembling T-cell lymphomas. Cancer 56:1578–1583

  17. 17.

    Ng CS, Chan JKC, Hui PK, Lau WH (1989) Large B-cell lymphomas with a high content of reactive T cells. Hum Pathol 20:1145–1154

  18. 18.

    Osborne BM, Butler JJ, Pugh WC (1990) The value of immunophenotyping on paraffin sections in the identification of T-cell rich B-cell lymphomas: lineage confirmed by JH rearrangement. Am J Surg Pathol 14:933–938

  19. 19.

    Ramsay AD, Smith WJ, Isaacson PG (1988) T-cell rich B-cell lymphoma. Am J Surg Pathol 12:433–443

  20. 20.

    Schmidt U, Metz KA, Leder LD (1995) T-cell rich B-cell lymphoma and lymphocyte-predominant Hodgkin's disease: two closely related entities? Br J Haematol 90:398–403

  21. 21.

    Tajima K, Fukase N, Shiono T, Katagiri T, Mito S (1995) An autopsied case of T-cell rich B-cell lymphoma with general involvement. Intern Med 24:143–246

  22. 22.

    Tefferi A, Zeller RA, Banks PM, Therneau TM, Colgan JP (1990) Clinical correlates of distinct immunophenotypic and histologic categories of lymphocyte-predominance Hodgkin's disease. J Clin Oncol 8:1959–1965

Download references

Author information

Correspondence to J. Diebold.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Camilleri-Bröet, S., Molina, T., Audouin, J. et al. Morphological variability of tumour cells in T-cell-rich B-cell lymphoma. Vichows Archiv A Pathol Anat 429, 243–248 (1996). https://doi.org/10.1007/BF00198340

Download citation

Key words

  • T-cell-rich B-cell lymphoma
  • B-cell lymphoma
  • Hodgkin's disease