Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

The countering of diazoxide-induced vasodilatation by tenoxicam in normal volunteers

  • 16 Accesses


The effect of the nonsteroidal anti-inflammatory drug, tenoxicam, on diazoxide-induced lowering of standing diastolic blood pressure was explored in 10 normal volunteers.

With diazoxide there was a significant fall in the 5-min standing diastolic pressure, i.e. a median drop of 15.5, 11.0, 9.5 and 7.0 mm Hg at 10, 35, 75 and 105 min, respectively, but with the tenoxicam-diazoxide regimen this pressure did not differ significantly from baseline at any time point. Tenoxicam did not modify the diazoxide-induced changes in blood glucose and plasma insulin.

It may be that prostaglandins normally contribute to the lowering of peripheral vascular resistance, or that acutely-administered diazoxide enhances the release of vasodilatory prostaglandins.

This is a preview of subscription content, log in to check access.


  1. Baez MA, Alvarez CR, Weidler DJ (1987) Effects of the non-steroidal anti-inflammatory drugs, piroxicam or sulindac, on the antihypertensive actions of propranolol and verapamil. J Hypertens [Suppl 5]: S563-S566

  2. Daniel WW (1990) Applied nonparametric statistics, 2 edn. PWS — Kent, Boston, pp 156–157

  3. Fajans SS, Floyd JC, Knopf RF, Rull J, Guntsche EM, Conn JW (1966) Benzothiadiazine suppression of insulin release from normal and abnormal islet tissue in man. J Clin Invest 45: 481–492

  4. Houston MC (1991) Nonsteroidal anti-inflammatory drugs and antihypertensives. tAm J Med 90: 42 S–47 S

  5. Newgreen DT, Bray KM, McHarg AD, Weston AH, Duty S, Brown BS, Kay PB, Edwards G, Longmore J, Southerton JS (1990) The action of diazoxide and minoxidil sulphate on rat blood vessels: a comparison with cromakalim. Br J Pharmacol 100: 605–613

  6. Olczak SA, Greenwood RH, Hales CN (1986) Post-receptor insulin resistance after diazoxide in non-insulin dependent diabetes. Horm Metab Res 18: 38–41

  7. Runyan TW (1962) Influence of thiazide diuretics on carbohydrate metabolism in patients with mild diabetes. N Engl J Med 267: 541–543

  8. Sommers De K, van Wyk M, Snyman JR (1992) Studies on the mode of action of diazoxide in normal volunteers. Asia Pac J Pharmacol 7: 225–229

  9. Takeuchi K, Abe K, Yasujima M, Sato M, Tanno M, Sato K, Yoshinaga K (1991) No adverse effect of non-steroidal anti-inflammatory drugs, sulindac and diclofenac sodium, on blood pressure control with a calcium antagonist. Tohoku J Exp Med 165: 201–208

Download references

Author information

Correspondence to K. De Sommers.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

De Sommers, K., van Wyk, M. & Snyman, J.R. The countering of diazoxide-induced vasodilatation by tenoxicam in normal volunteers. Eur J Clin Pharmacol 46, 569–571 (1994). https://doi.org/10.1007/BF00196119

Download citation

Key words

  • Diazoxide
  • Tenoxicam
  • diastolic pressure
  • glucose
  • insulin